Pinecone ofPinus koraiensisInducing Apoptosis in Human Lung Cancer Cells by Activating Caspase-3 and its Chemical Constituents

2017 ◽  
Vol 14 (4) ◽  
pp. e1600412 ◽  
Author(s):  
Tae Kyoung Lee ◽  
Hyun-Soo Roh ◽  
Jae Sik Yu ◽  
Jiwon Baek ◽  
Seul Lee ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Human Lung ◽  
Chemical Constituents ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

scholarly journals Momordica charantia (Indian and Chinese Bitter Melon) Extracts Inducing Apoptosis in Human Lung Cancer Cell Line A549 via ROS-Mediated Mitochodria Injury

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Siroshini Thiagarajan ◽  
Daryl J. Arapoc ◽  
Nurul Husna Shafie ◽  
Yong Yoke Keong ◽  
Hasnah Bahari ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Caspase 3 ◽  
Human Lung ◽  
Momordica Charantia ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Bitter Melon ◽  
Human Lung Cancer Cells

Lung cancer is the leading cause of cancer related deaths worldwide with about 40% occurring in developing countries. The two varieties of Momordica charantia, which are Chinese and Indian bitter melon, have been subjected to antiproliferative activity in human non-small cell lung cells A549. The A549 cells were treated with hot and cold aqueous extraction for both the bitter melon varieties, and the antiproliferative activity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The apoptotic mechanism of action on A549 human lung cancer cells was evaluated first morphologically using Hoechst 33358, and cytoskeleton staining using Filamentous-actin (F-actin) cytoskeleton FICT and DAPI followed by caspase-3/7, reactive oxygen species (ROS), and p53 activity. Chinese hot aqueous extraction (CHA) exhibited potent antiproliferative activity against A549 human lung cancer cells. The morphological analysis of mitochondria destruction and the derangement of cytoskeleton showed apoptosis-inducing activity. CHA increased the caspase-3/7 activity by 1.6-fold and the ROS activity by 5-fold. Flow cytometric analysis revealed 34.5% of apoptotic cells significantly (p<0.05) compared to cisplatin-treated A549 human cancer cells. CHA is suggested to induce apoptosis due to their rich bioactive chemical constituents. These findings suggest that the antiproliferative effect of CHA was due to apoptosis via ROS-mediated mitochondria injury.

Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells

2006 ◽  
Vol 16 (1) ◽  
pp. 81-83 ◽  
Author(s):  
AiYing Du ◽  
BaoXiang Zhao ◽  
DeLing Yin ◽  
ShangLi Zhang ◽  
JunYing Miao
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

scholarly journals Lafoensia pacari extract induces apoptosis mediated by caspase-3 and inhibition of growth in human lung cancer cells

2013 ◽  
Vol 7 (Suppl 2) ◽  
pp. P70
Author(s):  
Yonara G Cordeiro ◽  
Arina L Rochetti ◽  
Antônio M Scatolini ◽  
Edson R Silva ◽  
Vinicius C Souza ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Inhibition Of Growth ◽  
Human Lung Cancer Cells

Inhibitory effects of Actinidia Chinensis planch root extracts (acRoots) on human lung cancer cells through retinoic acid receptor beta

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Lingyan Wang ◽  
Jiayun Hou ◽  
Minghuan Zheng ◽  
Lin Shi
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Retinoic Acid Receptor ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Inhibitory Effects ◽  
The Core ◽  
Human Lung Cancer Cells ◽  
Receptor Beta

Actinidia Chinensis Planch roots (acRoots) are used to treat many cancers, although the anti-tumor mechanism by which acRoots inhibit cancer cell growth remains unclear. The present study aims at investigating inhibitory effects of acRoots on human lung cancer cells and potential mechanisms. Our data demonstrate that the inhibitory effects of acRoots on lung cancer cells depend on genetic backgrounds and phenotypes of cells. We furthermore found the expression of metabolism-associated gene profiles varied between acRoots-hypersensitive (H460) or hyposensitive lung cancer cells (H1299) after screening lung cancer cells with different genetic backgrounds. We selected retinoic acid receptor beta (RARB) as the core target within metabolism-associated core gene networks and evaluated RARB changes and roles in cells treated with acRoots at different concentrations and timeframes. Hypersensitive cancer cells with the deletion of RARB expression did not response to the treatment with acRoots, while RARB deletion did not change effects of acRoots on hyposensitive cells. Thus, it seems that RARB as the core target within metabolism-associated networks plays important roles in the regulation of lung cancer cell sensitivity to acRoots.

EFFECTS OF OPIOIDS AND NICOTINE ON APOPTOSIS IN HUMAN LUNG CANCER CELLS

Analgesia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 548-552
Author(s):  
Rhoda Maneckjee ◽  
Kathleen Dehen ◽  
John D. Minna
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells
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