scholarly journals Nimesulide, a selective COX-2 inhibitor, acts synergistically with ionizing radiation against A549 human lung cancer cells through the activation of caspase-8 and caspase-3

2009 ◽  
Author(s):  
Hong
Keyword(s):  
Lung Cancer ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Caspase 8 ◽  
Human Lung Cancer Cells ◽  
Cox 2

scholarly journals Triterpenoids from the Leaves of Centella asiatica Inhibit Ionizing Radiation-Induced Migration and Invasion of Human Lung Cancer Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Ah-Reum Han ◽  
Sanghun Lee ◽  
Sujin Han ◽  
Yeon Jin Lee ◽  
Jin-Baek Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Ionizing Radiation ◽  
Cancer Cells ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Migration And Invasion ◽  
Asiatic Acid ◽  
Human Lung Cancer Cells ◽  
Radiation Induced

Radiotherapy using ionizing radiation is a major therapeutic modality for advanced human lung cancers. However, ionizing radiation itself can induce malignant behaviors such as cancer cell migration and invasion, leading to local recurrence or distal metastasis. Therefore, safer and more effective agents that inhibit the metastatic behaviors of cancer cells in radiotherapy are needed. As a part of our ongoing search for new radiotherapy enhancers from medicinal herbs, we isolated the following triterpenoids from the ethanol extract of Centella asiatica: asiatic acid (1), madecassic acid (2), and asiaticoside (3). These compounds inhibited the ionizing radiation-induced migration and invasion of A549 human lung cancer cells at noncytotoxic concentrations. These results suggest that triterpenoids 1–3 isolated from C. asiatica are candidate natural compounds to enhance the effect of radiotherapy in patients with non-small-cell lung cancer.

scholarly journals Momordica charantia (Indian and Chinese Bitter Melon) Extracts Inducing Apoptosis in Human Lung Cancer Cell Line A549 via ROS-Mediated Mitochodria Injury

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Siroshini Thiagarajan ◽  
Daryl J. Arapoc ◽  
Nurul Husna Shafie ◽  
Yong Yoke Keong ◽  
Hasnah Bahari ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
Caspase 3 ◽  
Human Lung ◽  
Momordica Charantia ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Bitter Melon ◽  
Human Lung Cancer Cells

Lung cancer is the leading cause of cancer related deaths worldwide with about 40% occurring in developing countries. The two varieties of Momordica charantia, which are Chinese and Indian bitter melon, have been subjected to antiproliferative activity in human non-small cell lung cells A549. The A549 cells were treated with hot and cold aqueous extraction for both the bitter melon varieties, and the antiproliferative activity was evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The apoptotic mechanism of action on A549 human lung cancer cells was evaluated first morphologically using Hoechst 33358, and cytoskeleton staining using Filamentous-actin (F-actin) cytoskeleton FICT and DAPI followed by caspase-3/7, reactive oxygen species (ROS), and p53 activity. Chinese hot aqueous extraction (CHA) exhibited potent antiproliferative activity against A549 human lung cancer cells. The morphological analysis of mitochondria destruction and the derangement of cytoskeleton showed apoptosis-inducing activity. CHA increased the caspase-3/7 activity by 1.6-fold and the ROS activity by 5-fold. Flow cytometric analysis revealed 34.5% of apoptotic cells significantly (p<0.05) compared to cisplatin-treated A549 human cancer cells. CHA is suggested to induce apoptosis due to their rich bioactive chemical constituents. These findings suggest that the antiproliferative effect of CHA was due to apoptosis via ROS-mediated mitochondria injury.

Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells

2006 ◽  
Vol 16 (1) ◽  
pp. 81-83 ◽  
Author(s):  
AiYing Du ◽  
BaoXiang Zhao ◽  
DeLing Yin ◽  
ShangLi Zhang ◽  
JunYing Miao
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

scholarly journals Lafoensia pacari extract induces apoptosis mediated by caspase-3 and inhibition of growth in human lung cancer cells

2013 ◽  
Vol 7 (Suppl 2) ◽  
pp. P70
Author(s):  
Yonara G Cordeiro ◽  
Arina L Rochetti ◽  
Antônio M Scatolini ◽  
Edson R Silva ◽  
Vinicius C Souza ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Caspase 3 ◽  
Human Lung ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Inhibition Of Growth ◽  
Human Lung Cancer Cells
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