Synthesis and Spectroscopic Properties of Reconstituted ZincMyoglobin Appending a DNA-Binding Platinum(II) Complex

2008 ◽  
Vol 5 (10) ◽  
pp. 2101-2112 ◽  
Author(s):  
Hiroshi Takashima ◽  
Emi Fujimoto ◽  
Chiharu Hirai ◽  
Keiichi Tsukahara
Keyword(s):  
Dna Binding ◽  
Spectroscopic Properties ◽  
Zinc Myoglobin

scholarly journals Heterodimeric DNA-binding dyes designed for energy transfer: synthesis and spectroscopic properties

1993 ◽  
Vol 21 (24) ◽  
pp. 5727-5735 ◽  
Author(s):  
Scott C. Benson ◽  
Paramjit Singh ◽  
Alexander N. Glazer
Keyword(s):  
Energy Transfer ◽  
Dna Binding ◽  
Spectroscopic Properties

scholarly journals DNA binding properties of 2ʹ-hydroxyflavanon and Schiff base derivative

2019 ◽  
Vol 64 (2) ◽  
pp. 222-228
Author(s):  
V. M. Korolevich ◽  
P. Blazinska ◽  
A. Sykula ◽  
E. Lodyga-Chruscinska
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Spectroscopic Properties ◽  
Binding Properties ◽  
Base Modification ◽  
Whole Plant ◽  
Base Derivative ◽  
Anti Inflammatory ◽  
Dna Binding Properties

Flavanoids a class of plant and fungus secondary metabolites. 2ʹ-Hydroxyflavanone was previously isolated from Mimosa pudica (L.) whole plant and was found to exhibit anti-inflammatory effects in vitro and binding with calf timus DNA. There are also reports on anti-inflammatory properties of compounds bearing flavanone/chromone nucleus. The aim of this work was to develop a synthesis of new azomethine compounds derived from flavanones, to examine their spectroscopic properties and interaction with DNA. 2ʹ-Hydroxyflavanone and thiocarbohydrazide were used as substrates in the synthesis. The obtained products were analyzed by 1H NMR spectroscopy, UVVis. Ultraviolet spectroscopy was used to analyze the chemical-physical properties. Mechanism of interaction of bioactive 2ʹ-hydroxyflavanone with calf thymus deoxyribonucleic acid (DNA) was studied employing UV absorption. 2ʹ-Hydroxyflavanon and 2ʹHFTCH are photostable in DMSO. The interaction of 2ʹ-hydroxyflavanone and its derivative occurs by the mechanism of intercalation. The change in the structure of the 2ʹ-hydroxyflavanone molecule by Schiff base modification leads to an increase in DNA-binding properties. High binding ability of 2ʹ-hydroxyflavanone with DNA may be useful for development of new anti-inflammatory and antimicrobial remedies.

Biochemical and spectroscopic properties of DNA-binding zinc fingers: Application of Fmoc-mediated synthesis on PEG-polystyrene

Peptides ◽  
1992 ◽  
pp. 358-359 ◽  
Author(s):  
S. Biancalana ◽  
C. E. Dahl ◽  
H. T. Keutmann ◽  
D. Hudson ◽  
M. A. Marcus ◽  
...  
Keyword(s):  
Dna Binding ◽  
Zinc Fingers ◽  
Spectroscopic Properties

Rhenium complexes of chromophore-appended dipicolylamine ligands: syntheses, spectroscopic properties, DNA binding and X-ray crystal structure

2008 ◽  
Vol 32 (12) ◽  
pp. 2140 ◽  
Author(s):  
Lucy A. Mullice ◽  
Rebecca H. Laye ◽  
Lindsay P. Harding ◽  
Niklaas J. Buurma ◽  
Simon J. A. Pope
Keyword(s):  
Crystal Structure ◽  
Dna Binding ◽  
Spectroscopic Properties ◽  
Rhenium Complexes ◽  
X Ray

Synthesis, Characterization, and DNA Binding Studies of Ruthenium(II) Complexes with 2-Pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione

2008 ◽  
Vol 61 (9) ◽  
pp. 732 ◽  
Author(s):  
Yi-Xian Yuan ◽  
Yi-Can Wang ◽  
Long Jiang ◽  
Feng Gao ◽  
Si-Min Liang ◽  
...  
Keyword(s):  
Dna Binding ◽  
Imidazole Ring ◽  
Spectroscopic Properties ◽  
Spectroscopic Studies ◽  
X Ray Diffraction ◽  
Binding Studies ◽  
Base Pairs ◽  
Ancillary Ligands ◽  
Dna Base ◽  
Dna Binding Studies

Three novel asymmetric ruthenium(ii) complexes, [Ru(bpy)2(PAIDH)]2+ 1, [Ru(phen)2(PAIDH)]2+ 2, and [Ru(dmp)2(PAIDH)]2+ 3 (bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline, dmp = 2,9-dimethyl-1,10-phenanthroline, PAIDH = 2-pyridyl-1H-anthra[1,2-d]imidazole-6,11-dione), have been synthesized and characterized. The structure of the deprotonated complex [Ru(dmp)2(PAID)]+ 4 has been determined by single-crystal X-ray diffraction techniques, and the anthraquinone moiety is approximately coplanar with the imidazole ring. The DNA binding properities of complexes 1, 2, and 3 to calf-thymus DNA (CT-DNA) were investigated. Spectroscopic studies and viscosity experiments suggest that the RuII complexes intercalate into DNA base pairs by the extended anthraquinone unit, and the ancillary ligands have significant effects on the spectroscopic properties and DNA binding behaviour of the RuII complexes.

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