Cyclen-Based Side-Chain Homopolymer Self-Assembly with Plasmid DNA: Protection of DNA from Enzymatic Degradation

2009 ◽  
Vol 6 (5) ◽  
pp. 754-763 ◽  
Author(s):  
Kun Li ◽  
Na Wang ◽  
Fan Yang ◽  
Zhong-Wei Zhang ◽  
Li-Hong Zhou ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Self Assembly ◽  
Enzymatic Degradation ◽  
Side Chain ◽  
Dna Protection

Synthesis and self-assembly of thermotropic block copolymer with long alkyl tethered cage silsesquioxane in the side chain

2011 ◽  
Vol 49 (12) ◽  
pp. 2653-2664 ◽  
Author(s):  
Yoshihito Ishida ◽  
Tomoyasu Hirai ◽  
Raita Goseki ◽  
Masatoshi Tokita ◽  
Masa-Aki Kakimoto ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Self Assembly ◽  
Side Chain

Synthesis and self-assembly of side-chain azocomplex for preparation of solid and hollow nanosphere

2012 ◽  
Vol 290 (8) ◽  
pp. 741-749 ◽  
Author(s):  
Cheng Jin ◽  
Yongchao Zhao ◽  
Huixia Wang ◽  
Kunhua Lin ◽  
Qinjian Yin
Keyword(s):  
Self Assembly ◽  
Side Chain ◽  
Hollow Nanosphere

Click Synthesis of Shape-Persistent Azodendrimers and their Orthogonal Self-Assembly to Nanofibres

2018 ◽  
Vol 71 (6) ◽  
pp. 463 ◽  
Author(s):  
Tamer El Malah ◽  
Hany F. Nour
Keyword(s):  
Electron Microscopy ◽  
Mass Spectrometry ◽  
Self Assembly ◽  
Molecular Structures ◽  
Side Chain ◽  
Spectroscopic Techniques ◽  
Molecular Weights ◽  
Transmission Electron ◽  
Click Synthesis ◽  
Scanning Electron

The copper(i)-catalyzed azide–alkyne cycloaddition (CuAAC) reaction has been efficiently utilized to synthesize a series of dendrons with amino functionalities. The aminodendrons successfully underwent azodimerization to furnish a series of pyridyl- and phenyl-based azodendrimers with peripheral alkyl or ether side chain substituents. The molecular structures of the azodendrimers were fully assigned using different spectroscopic techniques, such as 1H NMR and 13C NMR, and the molecular weights were determined using MALDI-TOF mass spectrometry. The molecular self-assembly of the azodendrimers was investigated by scanning electron microscopy and transmission electron microscopy, which revealed the formation of highly ordered and uniform self-assembled nanofibres.

Intra-mitochondrial self-assembly to overcome the intracellular enzymatic degradation of l-peptides

2020 ◽  
Vol 56 (46) ◽  
pp. 6265-6268 ◽  
Author(s):  
M. T. Jeena ◽  
Seokyoung Lee ◽  
Ayan Kumar Barui ◽  
Seongeon Jin ◽  
Yuri Cho ◽  
...  
Keyword(s):  
Amino Acids ◽  
Self Assembly ◽  
Enzymatic Degradation ◽  
Therapeutic Efficiency

The design of peptide-based therapeutics is generally based on the replacement of l-amino acids with d-isomers to obtain improved therapeutic efficiency.

The influence of side-chain conformations on the phase behavior of bottlebrush block polymers

Soft Matter ◽  
2020 ◽  
Vol 16 (34) ◽  
pp. 8047-8056
Author(s):  
Yuguo Chen ◽  
Xinghua Zhang ◽  
Ying Jiang
Keyword(s):  
Self Assembly ◽  
Side Chain ◽  
Chain Model ◽  
Block Polymers ◽  
Consistent Field ◽  
Self Consistent Field ◽  
Self Consistent Field Theory ◽  
Assembly Behavior ◽  
Wormlike Chain Model ◽  
Chain Conformations

A self-consistent field theory based on the wormlike chain model is implemented in the investigation of the self-assembly behavior of bottlebrush block polymers in the formation of a lamellar phase.

scholarly journals Self-assembly of nucleopeptides to interact with DNAs

2017 ◽  
Vol 7 (6) ◽  
pp. 20160116 ◽  
Author(s):  
Xuewen Du ◽  
Jie Zhou ◽  
Xinming Li ◽  
Bing Xu
Keyword(s):  
Hydrogen Bonds ◽  
Plasmid Dna ◽  
Self Assembly ◽  
Unique Property ◽  
The Self ◽  
Proteinase K ◽  
Rational Approach ◽  
Proteolytic Resistance ◽  
Soft Biomaterials

As a novel class of biomaterials, nucleopeptides, via the conjugation of nucleobases and peptides, usually self-assemble to form nanofibres driven mainly by hydrogen bonds. Containing nucleobase(s), nucleopeptides have a unique property—interacting with nucleic acids. Here we report the design and characterization of nucleopeptides that self-assemble in water and are able to interact with single-stranded DNAs (ssDNAs). Containing nucleobases on their side chains, these nucleopeptides bind with the ssDNAs, and the ssDNAs reciprocally affect the self-assembly of nucleopeptides. In addition, the interactions between nucleopeptides and ssDNAs also decrease their proteolytic resistance against proteinase K, which further demonstrates the binding with ssDNAs. The nucleopeptides also interact with plasmid DNA and deliver hairpin DNA into cells. This work illustrates a new and rational approach to create soft biomaterials by the integration of nucleobases and peptides to bind with DNA, which may lead to the development of nucleopeptides for controlling DNA in cells.

Synthesis and self-assembly behaviours of side-chain smectic thiol–ene polymers based on the polysiloxane backbone

2016 ◽  
Vol 4 (7) ◽  
pp. 1425-1440 ◽  
Author(s):  
Wenhuan Yao ◽  
Yanzi Gao ◽  
Xiao Yuan ◽  
Baofeng He ◽  
Haifeng Yu ◽  
...  
Keyword(s):  
Liquid Crystal ◽  
Click Chemistry ◽  
Self Assembly ◽  
Side Chain ◽  
Liquid Crystal Polymers ◽  
Different Types

A series of novel chiral polysiloxane side chain liquid crystal polymers (PSCLCPs) with two different types of LC phases and three self-assembly arrangements were successfully synthesized via thiol–ene click chemistry.

Tetris in monolayers: patterned self-assembly using side chain shape

2011 ◽  
Vol 47 (31) ◽  
pp. 8832 ◽  
Author(s):  
Yi Xue ◽  
Matthew B. Zimmt
Keyword(s):  
Self Assembly ◽  
Side Chain
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