A Water-Soluble, Octacationic Zinc Phthalocyanine as Molecular Probe for Nucleic Acid Secondary Structure

2007 ◽  
Vol 4 (2) ◽  
pp. 215-223 ◽  
Author(s):  
An-Ming Zhang ◽  
Jing Huang ◽  
Xiao-Cheng Weng ◽  
Jin-Xi Li ◽  
Li-Ge Ren ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Secondary Structure ◽  
Water Soluble ◽  
Zinc Phthalocyanine ◽  
Molecular Probe

scholarly journals Recent Progress of Targeted G-Quadruplex-Preferred Ligands Toward Cancer Therapy

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 429 ◽  
Author(s):  
Sefan Asamitsu ◽  
Shunsuke Obata ◽  
Zutao Yu ◽  
Toshikazu Bando ◽  
Hiroshi Sugiyama
Keyword(s):  
Nucleic Acid ◽  
Secondary Structure ◽  
Recent Progress ◽  
Development Process ◽  
Protein Targeting ◽  
Molecular Probe ◽  
Drug Development Process ◽  
Quadruplex Structure ◽  
G4 Dna ◽  
G Quadruplex

A G-quadruplex (G4) is a well-known nucleic acid secondary structure comprising guanine-rich sequences, and has profound implications for various pharmacological and biological events, including cancers. Therefore, ligands interacting with G4s have attracted great attention as potential anticancer therapies or in molecular probe applications. To date, a large variety of DNA/RNA G4 ligands have been developed by a number of laboratories. As protein-targeting drugs face similar situations, G-quadruplex-interacting drugs displayed low selectivity to the targeted G-quadruplex structure. This low selectivity could cause unexpected effects that are usually reasons to halt the drug development process. In this review, we address the recent research on synthetic G4 DNA-interacting ligands that allow targeting of selected G4s as an approach toward the discovery of highly effective anticancer drugs.

scholarly journals Computer-aided nucleic acid secondary structure modeling incorporating enzymatic digestion data

1984 ◽  
Vol 12 (1Part1) ◽  
pp. 347-366 ◽  
Author(s):  
Gary J. Quigley ◽  
Lee Gehrke ◽  
David A. Roth ◽  
Philip E. Auron
Keyword(s):  
Nucleic Acid ◽  
Secondary Structure ◽  
Enzymatic Digestion ◽  
Structure Modeling ◽  
Computer Aided

Synthesis and Interaction of Water Soluble Nucleic Acid Analogs

1991 ◽  
pp. 31-45 ◽  
Author(s):  
Kiichi Takemoto ◽  
Takehiko Wada ◽  
Eiko Mochizuki ◽  
Yoshiaki Inaki
Keyword(s):  
Nucleic Acid ◽  
Water Soluble ◽  
Nucleic Acid Analogs

The effects of a water-soluble alpha tetra-substituted zinc phthalocyanine derivative onArthrospira platensis-M2 strain

2018 ◽  
Vol 22 (08) ◽  
pp. 686-692 ◽  
Author(s):  
Armağan Günsel ◽  
Hatice Tunca ◽  
Ahmet T. Bilgiçli ◽  
Ali Doğru ◽  
M. Nilüfer Yaraşir ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Biomass Accumulation ◽  
Arthrospira Platensis ◽  
Water Soluble ◽  
Zinc Phthalocyanine ◽  
Natural Environments ◽  
Oxygen Species ◽  
Sod Activity ◽  
Future Studies

In this study, we have analyzed the effect a newly synthesized water-soluble alpha tetra-substituted zinc phthalocyanine (Pc) compound on superoxide dismutase (SOD), ascorbate peroxidase (APX) and glutathione reductase (GR) activities and biomass accumulation in the Arthrospira platensis-M2 strain to test whether this compound could be used as an algaecide or not. We found that lower concentrations (3 μg mL[Formula: see text] and 6 μg mL[Formula: see text] of Pc compound were not toxic to algae cells, as indicated by enduring biomass accumulation during the study (7 days). Higher Pc concentrations, however, were toxic and inhibited biomass accumulation. This inhibition appeared on the fourth day and persisted during the study. At higher Pc concentrations, SOD activity decreased significantly, but APX and GR activity were not affected. These results may show that Pc applications did not cause the accumulation of reactive oxygen species in Arthrospira platensis-M2 cells. Our result suggests that higher Pc concentrations did not cause oxidative stress but biomass accumulation inhibited, possibly due to some different toxicity mechanism(s), which should be carried out in the future studies. As a result, we may offer use of this compound as a means to keep under control algal populations in natural environments.

RNA Structure Analysis: A Multifaceted Approach

1999 ◽  
Author(s):  
Bruce A. Shapiro ◽  
Wojciech Kasprzak
Keyword(s):  
Nucleic Acid ◽  
Secondary Structure ◽  
Tertiary Structure ◽  
Hammerhead Ribozyme ◽  
3D Structure ◽  
Computer Prediction ◽  
Rna Molecules ◽  
Tertiary Interactions ◽  
The One ◽  
Secondary And Tertiary Structure

Genomic information (nucleic acid and amino acid sequences) completely determines the characteristics of the nucleic acid and protein molecules that express a living organism’s function. One of the greatest challenges in which computation is playing a role is the prediction of higher order structure from the one-dimensional sequence of genes. Rules for determining macromolecule folding have been continually evolving. Specifically in the case of RNA (ribonucleic acid) there are rules and computer algorithms/systems (see below) that partially predict and can help analyze the secondary and tertiary interactions of distant parts of the polymer chain. These successes are very important for determining the structural and functional characteristics of RNA in disease processes and hi the cell life cycle. It has been shown that molecules with the same function have the potential to fold into similar structures though they might differ in their primary sequences. This fact also illustrates the importance of secondary and tertiary structure in relation to function. Examples of such constancy in secondary structure exist in transfer RNAs (tRNAs), 5s RNAs, 16s RNAs, viroid RNAs, and portions of retroviruses such as HIV. The secondary and tertiary structure of tRNA Phe (Kim et al., 1974), of a hammerhead ribozyme (Pley et al., 1994), and of Tetrahymena (Cate et al., 1996a, 1996b) have been shown by their crystal structure. Currently little is known of tertiary interactions, but studies on tRNA indicate these are weaker than secondary structure interactions (Riesner and Romer, 1973; Crothers and Cole, 1978; Jaeger et al., 1989b). It is very difficult to crystallize and/or get nuclear magnetic resonance spectrum data for large RNA molecules. Therefore, a logical place to start in determining the 3D structure of RNA is computer prediction of the secondary structure. The sequence (primary structure) of an RNA molecule is relatively easy to produce. Because experimental methods for determining RNA secondary and tertiary structure (when the primary sequence folds back on itself and forms base pairs) have not kept pace with the rapid discovery of RNA molecules and their function, use of and methods for computer prediction of secondary and tertiary structures have increasingly been developed.

A Water-Soluble Perylene Bisimide Cyclophane as a Molecular Probe for the Recognition of Aromatic Alkaloids

2019 ◽  
Vol 58 (11) ◽  
pp. 3516-3520 ◽  
Author(s):  
Meike Sapotta ◽  
Anja Hofmann ◽  
David Bialas ◽  
Frank Würthner
Keyword(s):  
Water Soluble ◽  
Molecular Probe ◽  
Perylene Bisimide
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