scholarly journals Relationship between circulating inflammatory factors and glioma risk and prognosis: A meta‐analysis

2019 ◽  
Vol 8 (17) ◽  
pp. 7454-7468 ◽  
Author(s):  
Yuan Feng ◽  
Jia Wang ◽  
Dezhong Tan ◽  
Peng Cheng ◽  
Anhua Wu
Keyword(s):  
Meta Analysis ◽  
Inflammatory Factors ◽  
Glioma Risk

Association between XRCC3 T241M polymorphism and glioma risk: a meta-analysis

Tumor Biology ◽  
2014 ◽  
Vol 35 (6) ◽  
pp. 5589-5592 ◽  
Author(s):  
Yiping Feng ◽  
Miaoyu Zeng ◽  
Qingsheng Xu
Keyword(s):  
Meta Analysis ◽  
Glioma Risk

scholarly journals Lack of association between modifiable exposures and glioma risk: A Mendelian randomisation analysis

2019 ◽  
Author(s):  
Charlie N Saunders ◽  
Alex J Cornish ◽  
Ben Kinnersley ◽  
Philip J Law ◽  
Elizabeth B Claus ◽  
...  
Keyword(s):  
Risk Factors ◽  
Genome Wide Association Study ◽  
Iron Status ◽  
Dietary Factors ◽  
Inflammatory Factors ◽  
Mendelian Randomisation ◽  
Omega 3 ◽  
Fat Percentage ◽  
A Genome ◽  
Glioma Risk

Abstract Background The etiological basis of glioma is poorly understood. We have used genetic markers in a Mendelian Randomisation (MR) framework to examine if lifestyle, cardiometabolic and inflammatory factors influence the risk of glioma. This methodology reduces bias from confounding and is not affected by reverse causation. Methods We identified genetic instruments for 37 potentially modifiable risk factors and evaluated their association with glioma risk using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. We used the estimated odds ratio of glioma associated with each of the genetically defined traits to infer evidence for a causal relationship with the following exposures: lifestyle and dietary factors (height, plasma IGF-1, blood carnitine, blood methionine, blood selenium, blood zinc, circulating adiponectin, circulating carotenoids, iron status, serum calcium, vitamin [A1, B12, B6, E and 25-hydroxyvitamin D], fatty acids levels [mono-unsaturated, omega-3 and omega-6] and circulating fetuin-A); cardiometabolic factors (birth weight, HDL cholesterol, LDL cholesterol, total cholesterol, total triglycerides, basal metabolic rate, body fat percentage, body mass index, fasting glucose, fasting proinsulin, HbA1C levels, diastolic and systolic blood pressure, waist circumference, waist-to-hip ratio) were included; inflammatory factors (C-reactive protein (CRP), plasma IL-6 sRa and serum IgE). Results After correction for the testing of multiple potential risk factors and excluding associations driven by one single nucleotide polymorphism (SNP) no significant association with glioma risk was observed (i.e. PCorrected > 0.05). Conclusions This study did not provide evidence supporting any of the 37 factors examined as having a significant influence on glioma risk.

scholarly journals Association between fish intake and glioma risk: a systematic review and meta-analysis

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052093969
Author(s):  
Honcho Lei ◽  
Chiho To ◽  
Unpeng Lei
Keyword(s):  
Effect Size ◽  
Observational Studies ◽  
Web Of Science ◽  
Meta Analysis ◽  
Fish Intake ◽  
Random Effects Model ◽  
Eligibility Criteria ◽  
Fresh Fish ◽  
Glioma Risk ◽  
The Relationship

Objectives We investigated the association between the consumption of fresh and processed fish and glioma risk using a meta-analysis approach. Methods We selected and analyzed observational studies that discussed the relationships between fresh and processed fish intake on glioma risk from PubMed, Web of Science, Embase, and the SinoMed and Wanfang databases from inception to 31 March 2020. Studies were selected according to pre-established eligibility criteria and data were extracted separately by two researchers. A meta-analysis was conducted based on a random-effects model to provide pooled odds ratios (OR) and 95% confidence intervals (CIs). Results Eight studies considered the relationship between fish intake (seven fresh and seven processed fish) and glioma risk and were included in this meta-analysis. The OR effect size for fresh fish intake and glioma risk was 0.72 (95%CI 0.53–0.97) and the overall OR effect size for processed fish intake and glioma risk was 1.88 (95%CI 1.06–3.34). Conclusion Dietary intake of fresh fish may reduce the risk of glioma, but consumption of processed fish may increase the risk of glioma. This study had some limitations, and further studies are therefore required to clarify the associations between fish intake and glioma risk.

scholarly journals Glutathione S-transferase genes variants and glioma risk: A case-control and meta-analysis study

2019 ◽  
Vol 10 (19) ◽  
pp. 4679-4688
Author(s):  
Weiping Liu ◽  
Hongyu Long ◽  
Mengqi Zhang ◽  
Yanjing Wang ◽  
Qiong Lu ◽  
...  
Keyword(s):  
Meta Analysis ◽  
Case Control ◽  
Glutathione S Transferase ◽  
Analysis Study ◽  
Glioma Risk

scholarly journals Effects of Flaxseed Interventions on Circulating Inflammatory Biomarkers: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

2019 ◽  
Vol 10 (6) ◽  
pp. 1108-1119 ◽  
Author(s):  
Mehran Rahimlou ◽  
Nasrin Banaie Jahromi ◽  
Nazila Hasanyani ◽  
Amirhossein Ramezani Ahmadi
Keyword(s):  
Weighted Mean Difference ◽  
Meta Analysis ◽  
High Sensitivity ◽  
Inflammatory Biomarkers ◽  
Inflammatory Factors ◽  
Reactive Protein ◽  
Hs Crp ◽  
Meta Analyses ◽  
Different Doses

ABSTRACT There have been various clinical studies on the effect of flaxseed-derived products on circulating inflammatory biomarkers, but the findings from these are contradictory. The aim of the present study was to clarify any association. A comprehensive literature search was conducted from inception to May 2018. From the eligible trials, 32 articles describing studies conducted on adults aged 18–70 y were selected for the meta-analysis. Meta-analyses using the random-effects model were performed to investigate the data and results showed significant effects of flaxseed intake on circulating high-sensitivity CRP (hs-CRP) [weighted mean difference (WMD) = −0.75; 95% CI: −1.19, −0.30; P < 0.001] and TNFα (WMD = −0.38; 95% CI: −0.75,–0.01; P = 0.04). However, no significant changes were found in IL6 concentration (WMD = −0.24; 95% CI: –0.70, 0.21; P = 0.28) and C-reactive protein (CRP) (WMD = −0.34; 95% CI:–0.89, 0.20; P = 0.22). Moreover, by eliminating 1 of the studies from the sensitivity analysis, changes in IL6 concentration were significant (WMD = −0.44; 95% CI: –0.81, –0.08). The changes in inflammatory biomarkers were dependent on study design (parallel or crossover), supplement type (flaxseed, flaxseed oil, or lignan), study quality (high or low), and participants’ age and BMI. According to this meta-analysis, flaxseed significantly reduced circulating concentrations of hs-CRP and TNFα, but did not affect IL6 and CRP. Further research is needed to examine the effect of different doses and long-term benefits of flaxseed and its derivatives on inflammatory factors.

A Comprehensive Meta-analysis of Genetic Associations Between Key Polymorphic Loci in DNA Repair Genes and Glioma Risk

2016 ◽  
Vol 54 (2) ◽  
pp. 1314-1325 ◽  
Author(s):  
Ling Qi ◽  
Hong-quan Yu ◽  
Yu Zhang ◽  
Li-juan Ding ◽  
Dong-hai Zhao ◽  
...  
Keyword(s):  
Dna Repair ◽  
Meta Analysis ◽  
Dna Repair Genes ◽  
Genetic Associations ◽  
Polymorphic Loci ◽  
Glioma Risk ◽  
Repair Genes

Update on the effect of exogenous hormone use on glioma risk in women: a meta-analysis of case-control and cohort studies

2017 ◽  
Vol 137 (2) ◽  
pp. 357-365 ◽  
Author(s):  
Yu-Long Lan ◽  
Xun Wang ◽  
Jia-Cheng Lou ◽  
Bin-Bin Ma ◽  
Jin-Shan Xing ◽  
...  
Keyword(s):  
Cohort Studies ◽  
Meta Analysis ◽  
Case Control ◽  
Exogenous Hormone ◽  
Glioma Risk ◽  
Hormone Use
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