scholarly journals Overexpression of PRDM5 promotes acute myeloid leukemia cell proliferation and migration by activating the JNK pathway

2019 ◽  
Author(s):  
Pan Zhou ◽  
Xing Chen ◽  
Mengke Li ◽  
Xiaolu Sun ◽  
Jiaqi Tan ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemia Cell ◽  
Jnk Pathway ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell ◽  
Proliferation And Migration

scholarly journals shRNA-mediated RPS15A silencing inhibits U937 acute myeloid leukemia cell proliferation and enhances apoptosis

2016 ◽  
Vol 13 (5) ◽  
pp. 4400-4406 ◽  
Author(s):  
GUANGYAO LI ◽  
LI ZHANG ◽  
JIZHU LIU ◽  
TAIWU XIAO ◽  
GUOZHEN LIU ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemia Cell ◽  
Acute Myeloid Leukemia Cell ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell

scholarly journals RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit

Oncotarget ◽  
2020 ◽  
Vol 11 (25) ◽  
pp. 2387-2403
Author(s):  
Hee-Don Chae ◽  
Ritika Dutta ◽  
Bruce Tiu ◽  
Fieke W. Hoff ◽  
Benedetta Accordi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemia Cell ◽  
Mitotic Exit ◽  
Acute Myeloid Leukemia Cell ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell

scholarly journals miR-4792 Inhibits Acute Myeloid Leukemia Cell Proliferation and Invasion and Promotes Cell Apoptosis by Targeting Kindlin-3

2020 ◽  
Vol 28 (4) ◽  
pp. 357-369
Author(s):  
Yun Qin ◽  
Yu Wang ◽  
Dongbo Liu
Keyword(s):  
Cell Proliferation ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemia Cell ◽  
Luciferase Reporter ◽  
Inhibitory Effects ◽  
Induced Apoptosis ◽  
Proliferation And Invasion ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell

It has been reported that kindlin-3 expression is closely associated with progression of many cancers and microRNA (miRNA) processing. However, the effects and precise mechanisms of kindlin-3 in acute myeloid leukemia (AML) have not been well clarified. Our study aimed to explore the interaction between kindlin-3 and miR-4792 in AML. In our study, we found that the expression of kindlin-3 was dramatically increased in AML samples and cell lines, and the miR-4792 level was significantly downregulated. Interestingly, the low miR-4792 level was closely associated with upregulated kindlin-3 expression in AML samples. Moreover, introduction of miR-4792 dramatically suppressed proliferation and invasion and induced apoptosis of AML cells. We demonstrated that miR-4792 could directly target kindlin-3 by using both bioinformatics analysis and luciferase reporter assay. In addition, kindlin-3 silencing had similar effects with miR-4792 overexpression on AML cells. Overexpression of kindlin-3 in AML cells partially reversed the inhibitory effects of miR-4792 mimic. miR-4792 inhibited cell proliferation and invasion and induced apoptosis of AML cells by directly downregulating kindlin-3 expression, and miR-4792 targeting kindlin-3 was responsible for the regulation of the proliferation, invasion, and apoptosis of AML cells.

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