scholarly journals RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation by targeting mitotic exit

Oncotarget ◽  
2020 ◽  
Vol 11 (25) ◽  
pp. 2387-2403
Author(s):  
Hee-Don Chae ◽  
Ritika Dutta ◽  
Bruce Tiu ◽  
Fieke W. Hoff ◽  
Benedetta Accordi ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemia Cell ◽  
Mitotic Exit ◽  
Acute Myeloid Leukemia Cell ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell

scholarly journals shRNA-mediated RPS15A silencing inhibits U937 acute myeloid leukemia cell proliferation and enhances apoptosis

2016 ◽  
Vol 13 (5) ◽  
pp. 4400-4406 ◽  
Author(s):  
GUANGYAO LI ◽  
LI ZHANG ◽  
JIZHU LIU ◽  
TAIWU XIAO ◽  
GUOZHEN LIU ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemia Cell ◽  
Acute Myeloid Leukemia Cell ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell

scholarly journals LINC01255 combined with BMI1 to regulate Human Mesenchymal Stromal Senescence and Acute myeloid leukemia cell proliferation through repress the transcription of MCP-1

2020 ◽  
Author(s):  
Qinghua Liu ◽  
Jing Dong ◽  
Jie Li ◽  
Yanchao Duan ◽  
Keqiang Wang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Bone Marrow Cells ◽  
Leukemia Cell ◽  
Acute Myeloid Leukemia Cell ◽  
Cell Viability Assay ◽  
Viability Assay ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell

Abstract Background: Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular biology processes, for example, participate in chromatin remodeling, imprinting, splicing, transcriptional regulation and translation. Dysregulation of lncRNA expression is act as a feature of various diseases and cancers, including hematopoietic malignancies. However, the clinical relevance of myelodysplastic syndrome (MDS) and acute myeloid leukemia preceded by MDS (MDS-AML) requires further research. Recently, lncRNAs have been demonstrated plays an important role in hematopoiesis, thus, to further finding more functional lncRNA seemed particularly important.Methods: Western blotting, real-time PCR, RNA-pulldown, RIP, Chromatin immunoprecipitation (ChIP), cellular compartments extraction assays, SA-β-gal staining, lentivirus transfection, cell viability assay and cell proliferation assays were used to examine the relationship between lncRNA LINC01255 and its regulation of p53-p21 pathway in human mesenchymal stromal and acute myeloid leukemia cells.Results: LncRNA LINC01255 is highly expressed in bone marrow cells of AML patients, CD34+ cells of MDS-AML patients and AML cell lines and the higher expression of LINC01255 is assocoated with poor survival rate of AML patients. LINC01255 can interact with BMI1 and repress the transcription of MCP-1 to active p53-p21 pathway, thus inhibiting the senescence of human mesenchymal stromal and proliferation of acute myeloid leukemia cell.Conclusions: We discovered a novel functional lncRNA LINC01255, which can regulate the senescence of human mesenchymal stromal and the proliferation of acute myeloid leukemia cell through inhibiting the transcription of MCP-1.

scholarly journals Niclosamide suppresses acute myeloid leukemia cell proliferation through inhibition of CREB-dependent signaling pathways

Oncotarget ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 4301-4317 ◽  
Author(s):  
Hee-Don Chae ◽  
Nick Cox ◽  
Gary V. Dahl ◽  
Norman J. Lacayo ◽  
Kara L. Davis ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Acute Myeloid Leukemia ◽  
Signaling Pathways ◽  
Myeloid Leukemia ◽  
Leukemia Cell ◽  
Acute Myeloid Leukemia Cell ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell

scholarly journals Author Correction: Targeting c-KIT (CD117) by dasatinib and radotinib promotes acute myeloid leukemia cell death

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sook-Kyoung Heo ◽  
Eui-Kyu Noh ◽  
Jeong Yi Kim ◽  
Yoo Kyung Jeong ◽  
Jae-Cheol Jo ◽  
...  
Keyword(s):  
Cell Death ◽  
Acute Myeloid Leukemia ◽  
Myeloid Leukemia ◽  
Leukemia Cell ◽  
Acute Myeloid Leukemia Cell ◽  
Acute Myeloid ◽  
Myeloid Leukemia Cell
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