scholarly journals The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation

2018 ◽  
Vol 7 (4) ◽  
pp. 1056-1069 ◽  
Author(s):  
Qinchao Hu ◽  
Tong Wu ◽  
Xiaobing Chen ◽  
Huan Li ◽  
Zhicheng Du ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Second Primary ◽  
Poor Outcome ◽  
The Poor

Prognostic Significance of BCL-2 Expression in Localized Squamous Cell Carcinoma of the Head and Neck

1997 ◽  
Vol 106 (6) ◽  
pp. 445-450 ◽  
Author(s):  
Philip Grey ◽  
Prashant Chawla ◽  
Michael Friedman ◽  
T. K. Venkatesan ◽  
David D. Caldarelli ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Early Stage ◽  
Prognostic Significance ◽  
Second Primary ◽  
Tissue Samples ◽  
Poor Outcome ◽  
Significant Difference

This study was conducted to determine whether Bcl-2 overexpression in localized squamous cell carcinoma of the head and neck (SCCHN) might serve as a marker for tumors unlikely to respond to standard treatment. Tissue samples from 33 patients undergoing surgery or irradiation for early-stage SCCHN during the years 1977 to 1992 were stained for Bcl-2. All patients had either T1N0 lesions of the oral cavity, pharynx, or larynx or T1 NO or T2N0 lesions of the true vocal cords. Of the 33 patients, 26 remained disease-free after at least 3 years of follow-up; the remaining 7 patients developed either tumor recurrence or a second primary tumor, 4 of which were fatal. Twelve patients had tissue specimens staining positive for Bcl-2; 6 of these patients had a poor outcome, and 6 had a good outcome. The relationship between poor outcome and overexpression of Bcl-2 in tumor cells was statistically significant (p =.0047 by Fisher's exact test). For tumors overexpressing Bcl-2, there was no significant difference in recurrence rate between those undergoing surgery and those undergoing radiotherapy as the primary mode of treatment. The overexpression of Bcl-2 in early lesions in this study predicted a cure rate of 50%, as opposed to the generally expected 90%, suggesting that Bcl-2 is a significant prognostic indicator in early SCCHN. Future studies will determine if altering the treatment will improve outcome in these patients.

Risk of second primary cancer in oral squamous cell carcinoma

Head & Neck ◽  
2020 ◽  
Vol 42 (8) ◽  
pp. 1848-1858
Author(s):  
Rayan Mroueh ◽  
Aapeli Nevala ◽  
Aaro Haapaniemi ◽  
Janne Pitkäniemi ◽  
Tuula Salo ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Second Primary ◽  
Primary Cancer ◽  
Second Primary Cancer

Methylation of RASSF1A, RASSF2A, and HIN-1 Is Associated with Poor Outcome after Radiotherapy, but not Surgery, in Oral Squamous Cell Carcinoma

2009 ◽  
Vol 15 (12) ◽  
pp. 4174-4180 ◽  
Author(s):  
Kuo-Hao Huang ◽  
Shiang-Fu Huang ◽  
I-How Chen ◽  
Chun-Ta Liao ◽  
Hung-Ming Wang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Poor Outcome

P3.26. Prognostic value of cyclin-D1 and p16 in second primary oral squamous cell carcinoma

2009 ◽  
Vol 3 (1) ◽  
pp. 209
Author(s):  
C. Magopoulos ◽  
T. Katopodi ◽  
F. Iordanidis ◽  
G. Theohari ◽  
A. Lambropoulos ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cyclin D1 ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Second Primary
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