Multifunctional siRNA delivery system: Polyelectrolyte complex micelles of six-arm PEG conjugate of siRNA and cell penetrating peptide with crosslinked fusogenic peptide

2009 ◽  
pp. NA-NA ◽  
Author(s):  
Sung Won Choi ◽  
Soo Hyeon Lee ◽  
Hyejung Mok ◽  
Tae Gwan Park
Keyword(s):  
Delivery System ◽  
Polyelectrolyte Complex ◽  
Sirna Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Complex Micelles ◽  
Sirna Delivery System

Targeted Delivery of siRNA Therapeutics using Ligand Mediated Biodegradable Polymeric Nanocarriers

2018 ◽  
Vol 24 (16) ◽  
pp. 1788-1800 ◽  
Author(s):  
Kye-Soo Cho ◽  
Seo-Jin Hong ◽  
Min-Hye Ahn ◽  
Sukdeb Pal ◽  
Pill-Hoon Choung ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Delivery System ◽  
Targeted Delivery ◽  
Sirna Delivery ◽  
Public Health Issue ◽  
Magic Bullet ◽  
Bodily Fluids ◽  
Low Cytotoxicity ◽  
Genetic And Environmental Factors ◽  
Sirna Delivery System

Background: Cancer poses a major public health issue, is linked with high mortality rates across the world, and shows a strong interplay between genetic and environmental factors. To date, common therapeutics, including chemotherapy, immunotherapy, and radiotherapy, have made significant contributions to cancer treatment, although diverse obstacles for achieving the permanent “magic bullet” cure have remained. Recently, various anticancer therapeutic agents designed to overcome the limitations of these conventional cancer treatments have received considerable attention. One of these promising and novel agents is the siRNA delivery system; however, poor cellular uptake and altered siRNA stability in physiological environments have limited its use in clinical trials. Therefore, developing the ideal siRNA delivery system with low cytotoxicity, improved siRNA stability in the body’s circulation, and prevention of its rapid clearance from bodily fluids, is rapidly emerging as an innovative therapeutic strategy to combat cancer. Moreover, active targeting using ligand moieties which bind to over-expressed receptors on the surface of cancer cells would enhance the therapeutic efficiency of siRNA. Conclusion: In this review, we provide 1) an overview of the non-viral carrier associated with siRNA delivery for cancer treatment, and 2) a description of the five major cancer-targeting ligands.

scholarly journals Novel Cell type-specific aptamer-siRNA delivery system for HIV-1 therapy

2007 ◽  
Author(s):  
Jiehua Zhou ◽  
Haitang Li ◽  
Shirley Li ◽  
John Zaia ◽  
John Rossi
Keyword(s):  
Delivery System ◽  
Sirna Delivery ◽  
Cell Type ◽  
Cell Type Specific ◽  
Hiv 1 ◽  
Sirna Delivery System

Biocompatible, chimeric peptide-condensed supramolecular nanoparticles for tumor cell-specific siRNA delivery and gene silencing

2014 ◽  
Vol 50 (58) ◽  
pp. 7806-7809 ◽  
Author(s):  
Hangxiang Wang ◽  
Wei Chen ◽  
Haiyang Xie ◽  
Xuyong Wei ◽  
Shengyong Yin ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Gene Silencing ◽  
Delivery System ◽  
Self Assembly ◽  
Sirna Delivery ◽  
Single Step ◽  
Chimeric Peptide ◽  
Supramolecular Nanoparticles ◽  
Sirna Delivery System

A practical and tumor cell-specific siRNA delivery system was developedviasingle-step self-assembly of an arginine-rich chimeric peptide with siRNA.

Nasal Administration of Cationic Nanoemulsions as CD73-siRNA Delivery System for Glioblastoma Treatment: a New Therapeutical Approach

2019 ◽  
Vol 57 (2) ◽  
pp. 635-649 ◽  
Author(s):  
J. H. Azambuja ◽  
R. S. Schuh ◽  
L. R. Michels ◽  
N. E. Gelsleichter ◽  
L. R. Beckenkamp ◽  
...  
Keyword(s):  
Delivery System ◽  
Sirna Delivery ◽  
Nasal Administration ◽  
Sirna Delivery System

Enhanced activity of vancomycin by encapsulation in hybrid magnetic nanoparticles conjugated to a cell-penetrating peptide

Nanoscale ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 3855-3870 ◽  
Author(s):  
Wenjie Zhang ◽  
Reza Taheri-Ledari ◽  
Zoleikha Hajizadeh ◽  
Ehsan Zolfaghari ◽  
Mohammad Reza Ahghari ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Delivery System ◽  
Cell Penetrating Peptide ◽  
Enhanced Activity ◽  
Cell Penetrating ◽  
A Cell ◽  
Antibiotic Delivery

We describe a novel antibiotic delivery system based on magnetic nanoparticles (NPs) conjugated to a cell-penetrating peptide (CPP).

scholarly journals Designing and enhancing the antifungal activity of corneal specific cell penetrating peptide using gelatin hydrogel delivery system

2019 ◽  
Vol Volume 14 ◽  
pp. 605-622 ◽  
Author(s):  
Chatterjee Amit ◽  
Shalini Muralikumar ◽  
Sargunam Janaki ◽  
Meena Lakshmipathy ◽  
Kulandhai Lilly Therese ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Delivery System ◽  
Cell Penetrating Peptide ◽  
Specific Cell ◽  
Gelatin Hydrogel ◽  
Cell Penetrating

scholarly journals Higher Order Architecture of Designer Peptides Forms Bioinspired 10 nm siRNA Delivery System

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Alicia Gamboa ◽  
Selina F. Urfano ◽  
Katrina Hernandez ◽  
Deborah A. Fraser ◽  
Luladey Ayalew ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Delivery System ◽  
Rational Design ◽  
Sirna Delivery ◽  
Higher Order ◽  
Collagen Peptide ◽  
Complex Forms ◽  
Quaternary Structures ◽  
Quaternary Complex ◽  
Sirna Delivery System

AbstractThe higher-order architecture observed in biological systems, like viruses, is very effective in nucleic acid transport. The replications of this system has been attempted with both synthetic and naturally occurring polymers with mixed results. Here we describe a peptide/siRNA quaternary complex that functions as an siRNA delivery system. The rational design of a peptide assembly is inspired by the viral capsids, but not derived from them. We selected the collagen peptide (COL) to provide the structural stability and the folding framework, and hybridize it with the cell penetrating peptide (CPP) that allows for effective penetration of biological barriers. The peptide/siRNA quaternary complex forms stoichiometric, 10 nm nanoparticles, that show fast cellular uptake (<30 min), effective siRNA release, and gene silencing. The complex provides capsid-like protection for siRNA against nucleases without being immunostimulatory, or cytotoxic. Our data suggests that delivery vehicles based on synthetic quaternary structures that exhibit higher-order architecture may be effective in improving delivery and release of nucleic acid cargo.

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