Enhanced activity of vancomycin by encapsulation in hybrid magnetic nanoparticles conjugated to a cell-penetrating peptide

Nanoscale ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 3855-3870 ◽  
Author(s):  
Wenjie Zhang ◽  
Reza Taheri-Ledari ◽  
Zoleikha Hajizadeh ◽  
Ehsan Zolfaghari ◽  
Mohammad Reza Ahghari ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Delivery System ◽  
Cell Penetrating Peptide ◽  
Enhanced Activity ◽  
Cell Penetrating ◽  
A Cell ◽  
Antibiotic Delivery

We describe a novel antibiotic delivery system based on magnetic nanoparticles (NPs) conjugated to a cell-penetrating peptide (CPP).

Dual-functionalized calcium carbonate based gene delivery system for efficient gene delivery

RSC Advances ◽  
2014 ◽  
Vol 4 (73) ◽  
pp. 38623-38629 ◽  
Author(s):  
Chao-Qun Wang ◽  
Meng-Qing Gong ◽  
Jin-Long Wu ◽  
Ren-Xi Zhuo ◽  
Si-Xue Cheng
Keyword(s):  
Calcium Carbonate ◽  
Gene Delivery ◽  
Delivery System ◽  
Gene Transfection ◽  
Cell Penetrating Peptide ◽  
Gene Delivery System ◽  
Dna Nanoparticles ◽  
Efficient Gene ◽  
Cell Penetrating ◽  
A Cell

Dual-functionalized KALA/PS/CaCO3/DNA nanoparticles containing a cell penetrating peptide (KALA) and protamine sulfate (PS) could effectively mediate gene transfection at a low DNA concentration.

Development of a Gene Delivery System Composed of a Cell-Penetrating Peptide and a Nontoxic Polymer

2020 ◽  
Vol 3 (11) ◽  
pp. 7418-7427
Author(s):  
Obdulia Covarrubias-Zambrano ◽  
Tej B. Shrestha ◽  
Marla Pyle ◽  
Maria Montes-Gonzalez ◽  
Deryl L. Troyer ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Cell Penetrating Peptide ◽  
Gene Delivery System ◽  
Cell Penetrating ◽  
A Cell

scholarly journals In vitro assessment of a novel polyrotaxane-based drug delivery system integrated with a cell-penetrating peptide

2007 ◽  
Vol 124 (1-2) ◽  
pp. 43-50 ◽  
Author(s):  
Cheol Moon ◽  
Young Min Kwon ◽  
Won Kyu Lee ◽  
Yoon Jeong Park ◽  
Victor C. Yang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell ◽  
In Vitro Assessment

A gene delivery system for human cells mediated by both a cell-penetrating peptide and a piggyBac transposase

Biomaterials ◽  
2011 ◽  
Vol 32 (26) ◽  
pp. 6264-6276 ◽  
Author(s):  
Cheng-Yi Lee ◽  
Jheng-Fong Li ◽  
Ji-Sing Liou ◽  
Yuh-Chyang Charng ◽  
Yue-Wern Huang ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Human Cells ◽  
Cell Penetrating Peptide ◽  
Gene Delivery System ◽  
Cell Penetrating ◽  
A Cell

scholarly journals Development of a pVEC peptide-based ribonucleoprotein (RNP) delivery system for genome editing using CRISPR/Cas9 in Chlamydomonas reinhardtii

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Seongsu Kang ◽  
Seungjib Jeon ◽  
Seungcheol Kim ◽  
Yong Keun Chang ◽  
Yeu-Chun Kim
Keyword(s):  
Chlamydomonas Reinhardtii ◽  
Genome Editing ◽  
Delivery System ◽  
Cell Biology ◽  
Algal Cell ◽  
Cell Penetrating Peptide ◽  
Simple Method ◽  
Cell Penetrating ◽  
Technical Advances ◽  
A Cell

AbstractRecent technical advances related to the CRISPR/Cas9-based genome editing system have enabled sophisticated genome editing in microalgae. Although the demand for research on genome editing in microalgae has increased over time, methodological research has not been established to date for the delivery of a ribonucleoprotein (Cas9/sgRNA complex) using a cell penetrating peptide into microalgal cell lines. Here, we present a ribonucleoprotein delivery system for Chlamydomonas reinhardtii mediated by the cell penetrating peptide pVEC (LLIILRRRIRKQAHAHSK) which is in a non-covalent form. Using this technically simple method, the ribonucleoprotein was successfully delivered into C. reinhardtii. Gene Maa7 and FKB12 were disrupted, and their distinguishing patterns of Indel mutations were analyzed with the observation of several insertions of sequences not originating from the genome DNA, such as chloroplast DNA, into the expected loci. In addition, the cytotoxicity of Cas9 and the ribonucleoprotein was investigated according to the concentration and time in the algal cells. It was observed that Cas9 alone without the sgRNA induces a more severe cytotoxicity compared to the ribonucleoprotein. Our study will not only contribute to algal cell biology and its genetic engineering for further applications involving various organisms but will also provide a deeper understating of the basic science of the CRISPR/Cas9 system.

Synthesis and in vitro evaluation of fluorescent and magnetic nanoparticles functionalized with a cell penetrating peptide for cancer theranosis

2017 ◽  
Vol 499 ◽  
pp. 209-217 ◽  
Author(s):  
Emiliana Perillo ◽  
Katel Hervé-Aubert ◽  
Emilie Allard-Vannier ◽  
Annarita Falanga ◽  
Stefania Galdiero ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Cell Penetrating Peptide ◽  
In Vitro Evaluation ◽  
Cell Penetrating ◽  
A Cell

scholarly journals A Cell-Penetrating Peptide with a Guanidinylethyl Amine Structure Directed to Gene Delivery

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Makoto Oba ◽  
Takuma Kato ◽  
Kaori Furukawa ◽  
Masakazu Tanaka
Keyword(s):  
Gene Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
Amine Structure ◽  
A Cell
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