Cation exchange chromatography performed in overloaded mode is effective in removing viruses during the manufacturing of monoclonal antibodies

Yumiko Masuda; Masashi Tsuda; Chie Hashikawa‐Muto; Yusuke Takahashi; Koichi Nonaka; Kaori Wakamatsu

doi:10.1002/btpr.2858

Cation exchange chromatography performed in overloaded mode is effective in removing viruses during the manufacturing of monoclonal antibodies

Biotechnology Progress ◽

10.1002/btpr.2858 ◽

2019 ◽

Vol 35 (5) ◽

Cited By ~ 2

Author(s):

Yumiko Masuda ◽

Masashi Tsuda ◽

Chie Hashikawa‐Muto ◽

Yusuke Takahashi ◽

Koichi Nonaka ◽

...

Keyword(s):

Monoclonal Antibodies ◽

Cation Exchange ◽

Exchange Chromatography ◽

Cation Exchange Chromatography

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The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies

Protein Science ◽

10.1002/pro.396 ◽

2010 ◽

Vol 19 (6) ◽

pp. 1191-1204 ◽

Cited By ~ 40

Author(s):

Shuang Chen ◽

Hollis Lau ◽

Yan Brodsky ◽

Gerd R. Kleemann ◽

Ramil F. Latypov

Keyword(s):

Monoclonal Antibodies ◽

Phase Separation ◽

Cation Exchange ◽

Exchange Chromatography ◽

Cation Exchange Chromatography

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Combination of zetaprep mass ion-exchange media and high-performance cation-exchange chromatography for the purification of high-purity monoclonal antibodies

Journal of Chromatography A ◽

10.1016/s0021-9673(01)85014-7 ◽

1987 ◽

Vol 397 ◽

pp. 313-320 ◽

Cited By ~ 12

Author(s):

A. Jungbauer ◽

F. Unterluggauer ◽

F. Steindl ◽

F. Rüker ◽

H. Katinger

Keyword(s):

Monoclonal Antibodies ◽

Ion Exchange ◽

Cation Exchange ◽

High Purity ◽

High Performance ◽

Exchange Chromatography ◽

Cation Exchange Chromatography

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Purification of in vitro produced mouse monoclonal antibodies. A two-step procedure utilizing cation exchange chromatography and gel filtration

Journal of Immunological Methods ◽

10.1016/0022-1759(85)90395-3 ◽

1985 ◽

Vol 79 (1) ◽

pp. 89-98 ◽

Cited By ~ 42

Author(s):

Mats Carlsson ◽

Anders Hedin ◽

Mats Inganäs ◽

Bengt Härfast ◽

Fred Blomberg

Keyword(s):

Monoclonal Antibodies ◽

Cation Exchange ◽

Gel Filtration ◽

Exchange Chromatography ◽

Cation Exchange Chromatography ◽

Step Procedure

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Fast determination of conditions for maximum dynamic capacity in cation-exchange chromatography of human monoclonal antibodies

Journal of Chromatography A ◽

10.1016/j.chroma.2007.03.114 ◽

2007 ◽

Vol 1161 (1-2) ◽

pp. 29-35 ◽

Cited By ~ 27

Author(s):

Alexander Faude ◽

Dörthe Zacher ◽

Egbert Müller ◽

Heiner Böttinger

Keyword(s):

Monoclonal Antibodies ◽

Cation Exchange ◽

Exchange Chromatography ◽

Cation Exchange Chromatography ◽

Human Monoclonal Antibodies ◽

Fast Determination ◽

Dynamic Capacity

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Use of chelating agents to improve the resolution and consistency of cation-exchange chromatography of monoclonal antibodies

Journal of Chromatography A ◽

10.1016/j.chroma.2014.09.051 ◽

2014 ◽

Vol 1367 ◽

pp. 109-117 ◽

Cited By ~ 2

Author(s):

Liangyi Zhang ◽

Thomas J. Robinson ◽

Brian D. Schmidt

Keyword(s):

Monoclonal Antibodies ◽

Cation Exchange ◽

Chelating Agents ◽

Exchange Chromatography ◽

Cation Exchange Chromatography

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Advance chromatin extraction enhances performance and productivity of cation exchange chromatography-based capture of Immunoglobulin G monoclonal antibodies

Journal of Chromatography A ◽

10.1016/j.chroma.2016.05.029 ◽

2016 ◽

Vol 1453 ◽

pp. 54-61 ◽

Cited By ~ 10

Author(s):

Rui Nian ◽

Pete Gagnon

Keyword(s):

Monoclonal Antibodies ◽

Cation Exchange ◽

Immunoglobulin G ◽

Exchange Chromatography ◽

Cation Exchange Chromatography

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Evaluation of high-capacity cation exchange chromatography for direct capture of monoclonal antibodies from high-titer cell culture processes

Biotechnology and Bioengineering ◽

10.1002/bit.25192 ◽

2014 ◽

Vol 111 (7) ◽

pp. 1354-1364 ◽

Cited By ~ 25

Author(s):

Yinying Tao ◽

Aladein Ibraheem ◽

Lynn Conley ◽

Douglas Cecchini ◽

Sanchayita Ghose

Keyword(s):

Cell Culture ◽

Monoclonal Antibodies ◽

Cation Exchange ◽

High Titer ◽

High Capacity ◽

Exchange Chromatography ◽

Cation Exchange Chromatography ◽

Direct Capture

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pH-based cation exchange chromatography in the capture and elution of monoclonal antibodies

Journal of Separation Science ◽

10.1002/jssc.201100720 ◽

2011 ◽

Vol 35 (1) ◽

pp. 29-35 ◽

Cited By ~ 8

Author(s):

Paul K. Ng ◽

Mark A. Snyder

Keyword(s):

Monoclonal Antibodies ◽

Cation Exchange ◽

Exchange Chromatography ◽

Cation Exchange Chromatography

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Displacement to separate host‐cell proteins and aggregates in cation‐exchange chromatography of monoclonal antibodies

Biotechnology and Bioengineering ◽

10.1002/bit.27559 ◽

2020 ◽

Vol 118 (1) ◽

pp. 164-174

Author(s):

Ohnmar Khanal ◽

Vijesh Kumar ◽

Abraham M. Lenhoff

Keyword(s):

Monoclonal Antibodies ◽

Cation Exchange ◽

Host Cell ◽

Exchange Chromatography ◽

Cation Exchange Chromatography ◽

Host Cell Proteins

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Rational methods for predicting human monoclonal antibodies retention in protein A affinity chromatography and cation exchange chromatography

Journal of Chromatography A ◽

10.1016/j.chroma.2005.07.077 ◽

2005 ◽

Vol 1093 (1-2) ◽

pp. 126-138 ◽

Cited By ~ 39

Author(s):

Takashi Ishihara ◽

Toshihiko Kadoya ◽

Hideaki Yoshida ◽

Taro Tamada ◽

Shuichi Yamamoto

Keyword(s):

Monoclonal Antibodies ◽

Affinity Chromatography ◽

Cation Exchange ◽

Protein A ◽

Exchange Chromatography ◽

Cation Exchange Chromatography ◽

Human Monoclonal Antibodies

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