Enhanced process understanding and multivariate prediction of the relationship between cell culture process and monoclonal antibody quality

2017 ◽  
Vol 33 (5) ◽  
pp. 1368-1380 ◽  
Author(s):  
Michael Sokolov ◽  
Jonathan Ritscher ◽  
Nicola MacKinnon ◽  
Jonathan Souquet ◽  
Hervé Broly ◽  
...  
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Cell Culture Process ◽  
Process Understanding ◽  
Culture Process ◽  
Multivariate Prediction ◽  
The Relationship

Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody

2016 ◽  
Vol 33 (1) ◽  
pp. 181-191 ◽  
Author(s):  
Michael Sokolov ◽  
Jonathan Ritscher ◽  
Nicola MacKinnon ◽  
Jean-Marc Bielser ◽  
David Brühlmann ◽  
...  
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Process Development ◽  
Cell Culture Process ◽  
Culture Process

Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

2014 ◽  
Vol 188 ◽  
pp. 88-96 ◽  
Author(s):  
Marija Ivarsson ◽  
Thomas K. Villiger ◽  
Massimo Morbidelli ◽  
Miroslav Soos
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Process Parameters ◽  
Cell Culture Process ◽  
Culture Process ◽  
The Impact

APPLICATION OF AMBR15 MINIBIOREACTORS IN CHARACTERIZATION OF SUSPENSION MONOCLONAL ANTIBODY CHO-PRODUCER CELL CULTURE PROCESS BASED ON QBD PRINCIPLES

2021 ◽  
Vol 1 (19) ◽  
pp. 180-181
Author(s):  
A.N. Morozov ◽  
I.R. Yakhin
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Monoclonal Antibodies ◽  
Quality By Design ◽  
Systematic Approach ◽  
Cell Culture Process ◽  
Culture Process ◽  
Producer Cell

A systematic approach to characterizing the cell culture process of CHO-producers of monoclonal antibodies within the framework of the concept "Quality by design" (QbD) with the use of ambr15 mini-bioreactors (TAP Biosystems) is shown.

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