Fluctuations in dissolved oxygen concentration during a CHO cell culture process affects monoclonal antibody productivity and the sulfhydryl‐drug conjugation process

2018 ◽  
Vol 34 (6) ◽  
pp. 1427-1437 ◽  
Author(s):  
Michael B. Hippach ◽  
Ian Schwartz ◽  
Jian Pei ◽  
Jimmy Huynh ◽  
Yasuaki Kawai ◽  
...  
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Dissolved Oxygen ◽  
Cell Culture Process ◽  
Dissolved Oxygen Concentration ◽  
Cho Cell ◽  
Drug Conjugation ◽  
Culture Process ◽  
Antibody Productivity ◽  
Conjugation Process

scholarly journals Reduction of charge variants by CHO cell culture process optimization

2020 ◽  
Vol 72 (2) ◽  
pp. 259-269 ◽  
Author(s):  
Zhibing Weng ◽  
Jian Jin ◽  
ChunHua Shao ◽  
Huazhong Li
Keyword(s):  
Cell Culture ◽  
Process Optimization ◽  
Cell Culture Process ◽  
Cho Cell ◽  
Culture Process ◽  
Cho Cell Culture ◽  
Charge Variants

Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody

2016 ◽  
Vol 33 (1) ◽  
pp. 181-191 ◽  
Author(s):  
Michael Sokolov ◽  
Jonathan Ritscher ◽  
Nicola MacKinnon ◽  
Jean-Marc Bielser ◽  
David Brühlmann ◽  
...  
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Process Development ◽  
Cell Culture Process ◽  
Culture Process

Scale-up analysis for a CHO cell culture process in large-scale bioreactors

2009 ◽  
Vol 103 (4) ◽  
pp. 733-746 ◽  
Author(s):  
Zizhuo Xing ◽  
Brian M. Kenty ◽  
Zheng Jian Li ◽  
Steven S. Lee
Keyword(s):  
Cell Culture ◽  
Large Scale ◽  
Scale Up ◽  
Cell Culture Process ◽  
Cho Cell ◽  
Culture Process ◽  
Cho Cell Culture

Evaluating the impact of cell culture process parameters on monoclonal antibody N-glycosylation

2014 ◽  
Vol 188 ◽  
pp. 88-96 ◽  
Author(s):  
Marija Ivarsson ◽  
Thomas K. Villiger ◽  
Massimo Morbidelli ◽  
Miroslav Soos
Keyword(s):  
Cell Culture ◽  
Monoclonal Antibody ◽  
Process Parameters ◽  
Cell Culture Process ◽  
Culture Process ◽  
The Impact

Transcriptome and proteome analysis of steady‐state in a perfusion CHO cell culture process

2019 ◽  
Vol 116 (8) ◽  
pp. 1959-1972 ◽  
Author(s):  
Vania Bertrand ◽  
Daniel J. Karst ◽  
Alessia Bachmann ◽  
Katia Cantalupo ◽  
Miroslav Soos ◽  
...  
Keyword(s):  
Cell Culture ◽  
Steady State ◽  
Proteome Analysis ◽  
Cell Culture Process ◽  
Cho Cell ◽  
Culture Process ◽  
Cho Cell Culture
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