Generic Raman-based calibration models enabling real-time monitoring of cell culture bioreactors

2015 ◽  
Vol 31 (4) ◽  
pp. 1004-1013 ◽  
Author(s):  
Hamidreza Mehdizadeh ◽  
David Lauri ◽  
Krizia M. Karry ◽  
Mojgan Moshgbar ◽  
Renee Procopio-Melino ◽  
...  
2016 ◽  
Vol 512 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Andrés D. Román-Ospino ◽  
Ravendra Singh ◽  
Marianthi Ierapetritou ◽  
Rohit Ramachandran ◽  
Rafael Méndez ◽  
...  

2016 ◽  
Vol 11 (9) ◽  
pp. 1179-1189 ◽  
Author(s):  
Alexandre Super ◽  
Nicolas Jaccard ◽  
Marco Paulo Cardoso Marques ◽  
Rhys Jarred Macown ◽  
Lewis Donald Griffin ◽  
...  

2016 ◽  
Vol 77 ◽  
pp. 56-61 ◽  
Author(s):  
Sun-Mi Lee ◽  
Nalae Han ◽  
Rimi Lee ◽  
In-Hong Choi ◽  
Yong-Beom Park ◽  
...  

Nanomaterials ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 588 ◽  
Author(s):  
Jeong Hwa Kim ◽  
Ju Young Park ◽  
Songwan Jin ◽  
Sik Yoon ◽  
Jong-Young Kwak ◽  
...  

Recently, three-dimensional (3D) cell culture and tissue-on-a-chip application have attracted attention because of increasing demand from the industries and their potential to replace conventional two-dimensional culture and animal tests. As a result, numerous studies on 3D in-vitro cell culture and microfluidic chip have been conducted. In this study, a microfluidic chip embracing a nanofiber scaffold is presented. A electrospun nanofiber scaffold can provide 3D cell culture conditions to a microfluidic chip environment, and its perfusion method in the chip can allow real-time monitoring of cell status based on the conditioned culture medium. To justify the applicability of the developed chip to 3D cell culture and real-time monitoring, HepG2 cells were cultured in the chip for 14 days. Results demonstrated that the cells were successfully cultured with 3D culture-specific-morphology in the chip, and their albumin and alpha-fetoprotein production was monitored in real-time for 14 days.


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