scholarly journals Microfluidics‐based 3D cell culture models: Utility in novel drug discovery and delivery research

2016 ◽  
Vol 1 (1) ◽  
pp. 63-81 ◽  
Author(s):  
Nilesh Gupta ◽  
Jeffrey R. Liu ◽  
Brijeshkumar Patel ◽  
Deepak E. Solomon ◽  
Bhuvaneshwar Vaidya ◽  
...  
Keyword(s):  
Cell Culture ◽  
Drug Discovery ◽  
3D Cell Culture ◽  
Culture Models ◽  
Novel Drug ◽  
Cell Culture Models

Generation and Analysis of 3D Cell Culture Models for Drug Discovery

2021 ◽  
pp. 105876
Author(s):  
Lisa Belfiore ◽  
Behnaz Aghaei ◽  
Andrew M.K. Law ◽  
Jeremy C. Dobrowolski ◽  
Lyndon J. Raftery ◽  
...  
Keyword(s):  
Cell Culture ◽  
Drug Discovery ◽  
3D Cell Culture ◽  
Culture Models ◽  
Cell Culture Models

scholarly journals 3D Tissue Models as an Effective Tool for Studying Viruses and Vaccine Development

2021 ◽  
Vol 8 ◽  
Author(s):  
Nathan Lawko ◽  
Charlie Plaskasovitis ◽  
Carling Stokes ◽  
Laila Abelseth ◽  
Ian Fraser ◽  
...  
Keyword(s):  
Cell Culture ◽  
Drug Discovery ◽  
Vaccine Development ◽  
Rapid Development ◽  
3D Cell Culture ◽  
Host Cells ◽  
Culture Models ◽  
Cell Culture Models ◽  
Cell Cell

The recent SARS-CoV-2 outbreak has researchers working tirelessly to understand the virus' pathogenesis and develop an effective vaccine. The urgent need for rapid development and deployment of such a vaccine has illustrated the limitations of current practices, and it has highlighted the need for alternative models for early screening of such technologies. Traditional 2D cell culture does not accurately capture the effects of a physiologically relevant environment as they fail to promote appropriate cell-cell and cell-environment interactions. This inability to capture the intricacies of the in vivo microenvironment prevents 2D cell cultures from demonstrating the necessary properties of native tissues required for the standard infection mechanisms of the virus, thus contributing the high failure rate of drug discovery and vaccine development. 3D cell culture models can bridge the gap between conventional cell culture and in vivo models. Methods such as 3D bioprinting, spheroids, organoids, organ-on-chip platform, and rotating wall vessel bioreactors offer ways to produce physiologically relevant models by mimicking in vivo microarchitecture, chemical gradients, cell–cell interactions and cell–environment interactions. The field of viral biology currently uses 3D cell culture models to understand the interactions between viruses and host cells, which is crucial knowledge for vaccine development. In this review, we discuss how 3D cell culture models have been used to investigate disease pathologies for coronaviruses and other viruses such as Zika Virus, Hepatitis, and Influenza, and how they may apply to drug discovery and vaccine development.

scholarly journals Conjunctival melanoma and electrochemotherapy: preliminary results using 2D and 3D cell culture models in vitro

2018 ◽  
Vol 97 (4) ◽  
pp. e632-e640 ◽  
Author(s):  
Miltiadis Fiorentzis ◽  
Periklis Katopodis ◽  
Helen Kalirai ◽  
Berthold Seitz ◽  
Arne Viestenz ◽  
...  
Keyword(s):  
Cell Culture ◽  
3D Cell Culture ◽  
Conjunctival Melanoma ◽  
Preliminary Results ◽  
Culture Models ◽  
2D And 3D ◽  
Cell Culture Models

Organotypic 3D cell culture models: using the rotating wall vessel to study host–pathogen interactions

2010 ◽  
Vol 8 (11) ◽  
pp. 791-801 ◽  
Author(s):  
Jennifer Barrila ◽  
Andrea L. Radtke ◽  
Aurélie Crabbé ◽  
Shameema F. Sarker ◽  
Melissa M. Herbst-Kralovetz ◽  
...  
Keyword(s):  
Cell Culture ◽  
3D Cell Culture ◽  
Host Pathogen Interactions ◽  
Rotating Wall ◽  
Rotating Wall Vessel ◽  
Host Pathogen ◽  
Culture Models ◽  
Cell Culture Models

Length vs. stiffness: which plays a dominant role in the cellular uptake of fructose-based rod-like micelles by breast cancer cells in 2D and 3D cell culture models?

2018 ◽  
Vol 6 (25) ◽  
pp. 4223-4231 ◽  
Author(s):  
Jiacheng Zhao ◽  
Hongxu Lu ◽  
Yin Yao ◽  
Sylvia Ganda ◽  
Martina H. Stenzel
Keyword(s):  
Breast Cancer ◽  
Cell Culture ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Dominant Role ◽  
3D Cell Culture ◽  
Culture Models ◽  
Nano Rods ◽  
2D And 3D ◽  
Cell Culture Models

Internalization of rod-like micelles by breast cancer cells is significantly affected by the stiffness of nano-rods.

scholarly journals Untargeted Metabolite Mapping in 3D Cell Culture Models Using High Spectral Resolution FT-ICR Mass Spectrometry Imaging

2019 ◽  
Vol 91 (15) ◽  
pp. 9522-9529 ◽  
Author(s):  
Lulu H. Tucker ◽  
Gregory R. Hamm ◽  
Rebecca J. E. Sargeant ◽  
Richard J. A. Goodwin ◽  
C. Logan Mackay ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Cell Culture ◽  
Spectral Resolution ◽  
Mass Spectrometry Imaging ◽  
3D Cell Culture ◽  
High Spectral Resolution ◽  
Culture Models ◽  
Cell Culture Models ◽  
Ft Icr
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