scholarly journals The asymmetry of neural symptoms in Wilson's disease patients detecting by diffusion tensor imaging, resting-state functional MRI, and susceptibility-weighted imaging

2018 ◽  
Vol 8 (5) ◽  
pp. e00930 ◽  
Author(s):  
Xiang-xue Zhou ◽  
Xun-hua Li ◽  
Ding-bang Chen ◽  
Chao Wu ◽  
Li Feng ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Functional Mri ◽  
Resting State ◽  
Wilson’S Disease ◽  
Diffusion Tensor ◽  
Wilson's Disease ◽  
Susceptibility Weighted Imaging ◽  
The Asymmetry

scholarly journals Diffusion Tensor Imaging (DTI) and its clinical correlates in drug naïve Wilson’s disease

2013 ◽  
Vol 28 (3) ◽  
pp. 455-462 ◽  
Author(s):  
Rakesh Jadav ◽  
Jitender Saini ◽  
Sanjib Sinha ◽  
Bhavanishankara Bagepally ◽  
S. Rao ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Wilson’S Disease ◽  
Diffusion Tensor ◽  
Wilson's Disease ◽  
Clinical Correlates ◽  
Drug Naïve ◽  
Diffusion Tensor Imaging Dti

Advanced fetal MRI: Diffusion tensor imaging, spectroscopy, dynamic MRI, resting-state functional MRI

2015 ◽  
Vol 01 (03) ◽  
pp. 225-251 ◽  
Author(s):  
Salil Soman ◽  
Gregor Kasprian ◽  
Veronika Schopf ◽  
Vanessa Berger-Kulemann ◽  
Ursula Nemec ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
Functional Mri ◽  
Resting State ◽  
Diffusion Tensor ◽  
Imaging Spectroscopy ◽  
Fetal Mri ◽  
Dynamic Mri

Microstructure assessment of the thalamus in Wilson's disease using diffusion tensor imaging

2014 ◽  
Vol 69 (3) ◽  
pp. 294-298 ◽  
Author(s):  
G. Li ◽  
X. Zhou ◽  
P. Xu ◽  
X. Pan ◽  
Y. Chen
Keyword(s):  
Diffusion Tensor Imaging ◽  
Wilson’S Disease ◽  
Diffusion Tensor ◽  
Wilson's Disease

scholarly journals Study on Lesion Assessment of Cerebello-Thalamo-Cortical Network in Wilson’s Disease with Diffusion Tensor Imaging

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Anqin Wang ◽  
Hongli Wu ◽  
Chunsheng Xu ◽  
Lanfeng Tang ◽  
Jaeyoun Lee ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Basal Ganglia ◽  
Wilson’S Disease ◽  
Diffusion Tensor ◽  
Genetic Disorder ◽  
Red Nucleus ◽  
Wilson's Disease ◽  
Cortical Network ◽  
Advanced Technique

Wilson’s disease (WD) is a genetic disorder of copper metabolism with pathological copper accumulation in the brain and any other tissues. This article aimed to assess lesions in cerebello-thalamo-cortical network with an advanced technique of diffusion tensor imaging (DTI) in WD. 35 WD patients and 30 age- and sex-matched healthy volunteers were recruited to accept diffusion-weighted images with 15 gradient vectors and conventional magnetic resonance imaging (MRI). The DTI parameters, including fractional anisotropy (FA) and mean diffusion (MD), were calculated by diffusion kurtosis estimator software. After registration, patient groups with FA mappings and MD mappings and normal groups were compared with 3dttest and receiver-operating characteristic (ROC) curve analysis, corrected with FDR simulations (p=0.001, α=0.05, cluster size = 326). We found that the degree of FA increased in the bilateral head of the caudate nucleus (HCN), lenticular nucleus (LN), ventral thalamus, substantia nigra (SN), red nucleus (RN), right dentate nucleus (DN), and decreased in the mediodorsal thalamus and extensive white matter. The value of MD increased in HCN, LN, SN, RN, and extensive white matter. The technique of DTI provides higher sensitivity and specificity than conventional MRI to detect Wilson’s disease. Besides, lesions in the basal ganglia, thalamus, and cerebellum might disconnect the basal ganglia-thalamo-cortical circuits or dentato-rubro-thalamic (DRT) track and disrupt cerebello-thalamo-cortical network finally, which may cause clinical extrapyramidal symptoms.

scholarly journals Stuck in a State of Inattention? Functional Hyperconnectivity as an Indicator of Disturbed Intrinsic Brain Dynamics in Adolescents With Concussion: A Pilot Study

ASN NEURO ◽  
2018 ◽  
Vol 10 ◽  
pp. 175909141775380 ◽  
Author(s):  
Angela M. Muller ◽  
Naznin Virji-Babul
Keyword(s):  
Diffusion Tensor Imaging ◽  
Pilot Study ◽  
Resting State ◽  
Diffusion Tensor ◽  
Brain Dynamics ◽  
Public Health Issue ◽  
Brain Correlates ◽  
Brain States ◽  
The Brain ◽  
Structural Brain

Sports-related concussion in youth is a major public health issue. Evaluating the diffuse and often subtle changes in structure and function that occur in the brain, particularly in this population, remains a significant challenge. The goal of this pilot study was to evaluate the relationship between the intrinsic dynamics of the brain using resting-state functional magnetic resonance imaging (rs-fMRI) and relate these findings to structural brain correlates from diffusion tensor imaging in a group of adolescents with sports-related concussions ( n = 6) and a group of healthy adolescent athletes ( n = 6). We analyzed rs-fMRI data using a sliding windows approach and related the functional findings to structural brain correlates by applying graph theory analysis to the diffusion tensor imaging data. Within the resting-state condition, we extracted three separate brain states in both groups. Our analysis revealed that the brain dynamics in healthy adolescents was characterized by a dynamic pattern, shifting equally between three brain states; however, in adolescents with concussion, the pattern was more static with a longer time spent in one brain state. Importantly, this lack of dynamic flexibility in the concussed group was associated with increased nodal strength in the left middle frontal gyrus, suggesting reorganization in a region related to attention. This preliminary report shows that both the intrinsic brain dynamics and structural organization are altered in networks related to attention in adolescents with concussion. This first report in adolescents will be used to inform future studies in a larger cohort.

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