scholarly journals Left hippocampus-amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals

2015 ◽  
Vol 5 (7) ◽  
pp. n/a-n/a ◽  
Author(s):  
Antonietta Manna ◽  
Fabrizio Piras ◽  
Carlo Caltagirone ◽  
Paola Bossù ◽  
Stefano L. Sensi ◽  
...  
Keyword(s):  
Plasma Levels ◽  
Elderly Individuals ◽  
Healthy Elderly ◽  
Left Hippocampus

scholarly journals Effect of BCG vaccination on proinflammatory responses in elderly individuals

2021 ◽  
Vol 7 (32) ◽  
pp. eabg7181 ◽  
Author(s):  
Nathella Pavan Kumar ◽  
Chandrasekaran Padmapriyadarsini ◽  
Anuradha Rajamanickam ◽  
Shrinivasa B. Marinaik ◽  
Arul Nancy ◽  
...  
Keyword(s):  
Growth Factors ◽  
Plasma Levels ◽  
Inflammatory Responses ◽  
Acute Phase Proteins ◽  
Elderly Individuals ◽  
Bcg Vaccination ◽  
Healthy Elderly ◽  
Proinflammatory Responses ◽  
Unvaccinated Control

We investigated the influence of Bacillus Calmette-Guérin (BCG) vaccination on the unstimulated plasma levels of a wide panel of cytokines, chemokines, acute-phase proteins (APPs), matrix metalloproteinases (MMPs), and growth factors in a group of healthy elderly individuals (age, 60 to 80 years) at baseline (before vaccination) and 1 month after vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Our results demonstrated that BCG vaccination resulted in diminished plasma levels of types 1, 2, and 17 and other proinflammatory cytokines and type 1 interferons. BCG vaccination also resulted in decreased plasma levels of CC, CXC chemokines, APPs, MMPs, and growth factors. Plasma levels of the aforementioned parameters were significantly lower in vaccinated individuals when compared to unvaccinated control individuals. Thus, our study demonstrates the immunomodulatory properties of BCG vaccination and suggests its potential utility in nonspecific vaccination of COVID-19 by down-modulating pathogenic inflammatory responses.

Ascorbic Acid Intakes and Plasma Levels in Healthy Elderly

1987 ◽  
Vol 498 (1 Third Confere) ◽  
pp. 90-99 ◽  
Author(s):  
PHILIP J. GARRY ◽  
DOROTHY J. VANDERJAGT ◽  
WILLIAM C. HUNT
Keyword(s):  
Ascorbic Acid ◽  
Plasma Levels ◽  
Healthy Elderly

scholarly journals Impaired abstract thinking may discriminate between normal aging and vascular mild cognitive impairment

2010 ◽  
Vol 68 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Felipe Kenji Sudo ◽  
Gilberto Sousa Alves ◽  
Carlos Eduardo de Oliveira Alves ◽  
Maria Elisa Lanna ◽  
Letice Ericeira-Valente ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cerebrovascular Disease ◽  
Cognitive Deficits ◽  
Cross Sectional Study ◽  
Abstract Thinking ◽  
Sectional Study ◽  
Cross Sectional ◽  
Elderly Individuals ◽  
Healthy Elderly

OBJECTIVE: Cerebrovascular disease (CVD) is associated with cognitive deficits. This cross-sectional study examines differences among healthy elderly controls and patients with vascular mild cognitive impairment (VaMCI) and vascular dementia (VaD) in performances on CAMCOG subscales. METHOD: Elderly individuals (n=61) were divided into 3 groups, according to cognitive and neuroimaging status: 16 controls, 20 VaMCI and 25 VaD. VaMCI and VaD individuals scored over 4 points on the Hachinski Ischemic Scale. RESULTS: Significant differences in total CAMCOG scores were observed across the three groups (p<0.001). VaD subjects performed worse than those with VaMCI in most CAMCOG subscales (p<0.001). All subscales showed differences between controls and VaD (p<0.001). Performance on abstract thinking showed difference between VaMCI and controls (p<0.001). CONCLUSION: CAMCOG discriminated controls from VaMCI and VaD. Assessment of abstract thinking may be useful as a screening item for diagnosis of VaMCI.

scholarly journals BCG vaccination induces enhanced frequencies of memory T cells and altered plasma levels of common γc cytokines in elderly individuals

PLoS ONE ◽  
2021 ◽  
Vol 16 (11) ◽  
pp. e0258743
Author(s):  
Nathella Pavan Kumar ◽  
Chandrasekaran Padmapriyadarsini ◽  
Anuradha Rajamanickam ◽  
Perumal Kannabiran Bhavani ◽  
Arul Nancy ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
T Cell ◽  
Cd8 T Cells ◽  
Plasma Levels ◽  
T Cell Subsets ◽  
Effector Memory ◽  
Elderly Individuals ◽  
Bcg Vaccination ◽  
Adaptive Immune

BCG vaccination is known to induce innate immune memory, which confers protection against heterologous infections. However, the effect of BCG vaccination on the conventional adaptive immune cells subsets is not well characterized. We investigated the impact of BCG vaccination on the frequencies of T cell subsets and common gamma c (γc) cytokines in a group of healthy elderly individuals (age 60–80 years) at one month post vaccination as part of our clinical study to examine the effect of BCG on COVID-19. Our results demonstrate that BCG vaccination induced enhanced frequencies of central (p<0.0001) and effector memory (p<0.0001) CD4+ T cells and diminished frequencies of naïve (p<0.0001), transitional memory (p<0.0001), stem cell memory (p = 0.0001) CD4+ T cells and regulatory T cells. In addition, BCG vaccination induced enhanced frequencies of central (p = 0.0008), effector (p<0.0001) and terminal effector memory (p<0.0001) CD8+ T cells and diminished frequencies of naïve (p<0.0001), transitional memory (p<0.0001) and stem cell memory (p = 0.0034) CD8+T cells. BCG vaccination also induced enhanced plasma levels of IL-7 (p<0.0001) and IL-15 (p = 0.0020) but diminished levels of IL-2 (p = 0.0033) and IL-21 (p = 0.0020). Thus, BCG vaccination was associated with enhanced memory T cell subsets as well as memory enhancing γc cytokines in elderly individuals, suggesting its ability to induce non-specific adaptive immune responses.

scholarly journals Medically actionable pathogenic variants in a population of 13,131 healthy elderly individuals

2020 ◽  
Vol 22 (11) ◽  
pp. 1883-1886 ◽  
Author(s):  
Paul Lacaze ◽  
Robert Sebra ◽  
Moeen Riaz ◽  
Jane Tiller ◽  
Jerico Revote ◽  
...  
Keyword(s):  
Elderly Individuals ◽  
Healthy Elderly ◽  
Pathogenic Variants

Factors related to masticatory performance in healthy elderly individuals

2018 ◽  
Vol 62 (4) ◽  
pp. 432-435 ◽  
Author(s):  
Koji Morita ◽  
Hiroki Tsuka ◽  
Kan Kato ◽  
Takahiro Mori ◽  
Rumi Nishimura ◽  
...  
Keyword(s):  
Masticatory Performance ◽  
Elderly Individuals ◽  
Healthy Elderly
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