Serum concentration of zinc is elevated in clinically stable bipolar disorder patients

The serum concentration of magnesium as a potential state marker in patients with diagnosis of bipolar disorder

Psychiatria Polska ◽

10.12740/pp/onlinefirst/42047 ◽

2015 ◽

Vol 49 (6) ◽

pp. 1277-1287 ◽

Cited By ~ 8

Author(s):

Marcin Siwek ◽

Krzysztof Styczeń ◽

Magdalena Sowa-Kućma ◽

Dominika Dudek ◽

Witold Reczyński ◽

...

Keyword(s):

Bipolar Disorder ◽

Serum Concentration ◽

State Marker

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Metabolic risk factors in schizophrenia and bipolar disorder: The effect of comedication with selective serotonin reuptake inhibitors and antipsychotics

European Psychiatry ◽

10.1016/j.eurpsy.2017.04.001 ◽

2018 ◽

Vol 48 (1) ◽

pp. 71-78 ◽

Cited By ~ 3

Author(s):

K.K. Fjukstad ◽

A. Engum ◽

S. Lydersen ◽

I. Dieset ◽

N. Eiel Steen ◽

...

Keyword(s):

Bipolar Disorder ◽

Serum Concentration ◽

Total Cholesterol ◽

Serotonin Reuptake ◽

Selective Serotonin Reuptake Inhibitors ◽

Ldl Cholesterol ◽

Serotonin Reuptake Inhibitors ◽

Selective Serotonin ◽

Defined Daily Dose ◽

Cross Sectional

AbstractBackgroundThe aim of this observational study was to investigate the relationship between metabolic factors and use of selective serotonin reuptake inhibitors (SSRIs) combined with olanzapine, quetiapine or risperidone.MethodsData from the Norwegian Thematically Organized Psychosis study, a cross-sectional study on 1301 patients with schizophrenia (n=868) or bipolar disorder (n=433), were analyzed. As exposure variables in the linear regression model were included the dose or serum concentration of SSRIs (n=280) and of olanzapine (n=398), quetiapine (n=234) or risperidone (n=128). The main outcome variables were levels of total cholesterol, low and high density lipoprotein (LDL and HDL) cholesterol, triglycerides and glucose.ResultsOne defined daily dose (DDD) per day of an SSRI in addition to olanzapine was associated with an increase in total cholesterol of 0.16 (CI 0.01 to 0.32) mmol/L (P=0.042) and an increase in LDL-cholesterol of 0.17 (CI 0.02 to 0.31) mmol/L (P=0.022). An SSRI serum concentration in the middle of the reference interval in addition to quetiapine was associated with an increase in total cholesterol of 0.39 (CI 0.10 to 0.68) mmol/L (P=0.011) and an increase in LDL-cholesterol of 0.29 (0.02 to 0.56) mmol/L (P=0.037). There were no such effects when combined with risperidone.ConclusionsThe findings indicate only minor deteriorations of metabolic variables associated with treatment with an SSRI in addition to olanzapine and quetiapine, and none when combined with risperidone. These results suggest that SSRIs can be used in combination with antipsychotics, and that the possible increase in cardiovascular risk is negligible.

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135. CRP Genetic Variants and Serum Concentration in Bipolar Disorder

Biological Psychiatry ◽

10.1016/j.biopsych.2017.02.147 ◽

2017 ◽

Vol 81 (10) ◽

pp. S56-S57

Author(s):

Sarah Kittel-Schneider ◽

Ann-Kristin Höh ◽

Julia Veeh ◽

Andreas Reif

Keyword(s):

Bipolar Disorder ◽

Serum Concentration ◽

Genetic Variants

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Increased Serum Cu/Zn SOD in Individuals with Bipolar Disorder

Proteomics Insights ◽

10.4137/pri.s5527 ◽

2010 ◽

Vol 3 ◽

pp. PRI.S5527

Author(s):

A.J. Russo

Keyword(s):

Bipolar Disorder ◽

Superoxide Dismutase ◽

Serum Concentration ◽

Serum Levels ◽

Age And Gender ◽

And Gender

Aim To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with bipolar disorder. Subjects and methods Serum from 20 individuals diagnosed with bipolar disorder and 20 age and gender similar controls were tested for Cu/Zn SOD serum concentration using ELISAs. Results Serum Cu/Zn SOD levels of individuals with bipolar disorder were significantly higher than age and gender matched controls. Discussion These results suggest an association between Cu/Zn SOD serum levels and bipolar disorder.

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Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Bipolar Disorder Normalizes after Zinc and Anti-oxidant Therapy

Nutrition and Metabolic Insights ◽

10.4137/nmi.s5528 ◽

2010 ◽

Vol 3 ◽

pp. NMI.S5528 ◽

Cited By ~ 1

Author(s):

A.J. Russo

Keyword(s):

Bipolar Disorder ◽

Serum Concentration ◽

Inductively Coupled Plasma ◽

Serum Levels ◽

Age And Gender ◽

Inductively Coupled ◽

Plasma Mass Spectrometry ◽

And Gender ◽

Zinc Levels ◽

Bipolar Patients

Aim To assess serum HGF concentration in individuals with bipolar disorder and investigate the efficacy of zinc therapy on these levels. Subjects and Methods Serum from 35 individuals diagnosed with bipolar disorder and 19 age and gender similar controls were tested for HGF concentration using ELISAs, and copper and zinc plasma levels using inductively-coupled plasma-mass spectrometry. Results HGF serum levels of individuals with bipolar disorder were significantly lower than age and gender similar controls ( P = 0.0021). HGF serum concentration was significantly lower in Bipolar patients pre-therapy ( P = 0.0009) and HGF levels normalized post-therapy. Zinc levels in these same individuals also normalized ( P = 0.0046) and patient's perceived severity of Bipolar symptoms significantly decreased after therapy ( P = 0.0003). We also found a significant direct correlation between Zinc and HGF serum concentration in the bipolar patients ( P = 0.04). Discussion These results suggest an association between low HGF levels and bipolar disorder and also demonstrate that zinc therapy may be associated with the normalization of HGF levels and decrease in severity of disease.

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The serum concentration of copper in bipolar disorder

Psychiatria Polska ◽

10.12740/pp/onlinefirst/65250 ◽

2017 ◽

Vol 51 (3) ◽

pp. 469-481 ◽

Cited By ~ 4

Author(s):

Marcin Siwek ◽

Krzysztof Styczeń ◽

Magdalena Sowa-Kućma ◽

Dominika Dudek ◽

Witold Reczyński ◽

...

Keyword(s):

Bipolar Disorder ◽

Serum Concentration

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Fibronexus-Like Adhesion Sites are Present at the Invasive Zones of Human Epidermoid Carcinomas

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053280 ◽

1982 ◽

Vol 40 ◽

pp. 106-109

Author(s):

Irwin I. Singer

Keyword(s):

Cell Cycle ◽

Serum Concentration ◽

Substrate Binding ◽

High Serum ◽

Adhesion Sites ◽

Substrate Adhesion ◽

Focal Contacts ◽

Adhesion Complex ◽

Low Serum

Our previous results indicate that two types of fibronectin-cytoskeletal associations may be formed at the fibroblast surface: dorsal matrixbinding fibronexuses generated in high serum (5% FBS) cultures, and ventral substrate-adhering units formed in low serum (0.3% FBS) cultures. The substrate-adhering fibronexus consists of at least vinculin (VN) and actin in its cytoplasmic leg, and fibronectin (FN) as one of its major extracellular components. This substrate-adhesion complex is localized in focal contacts, the sites of closest substratum approach visualized with interference reflection microscopy, which appear to be the major points of cell-tosubstrate adhesion. In fibroblasts, the latter substrate-binding complex is characteristic of cultures that are arrested at the G1 phase of the cell cycle due to the low serum concentration in their medium. These arrested fibroblasts are very well spread, flattened, and immobile.

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