scholarly journals Quantification of dexamethasone and corticosterone in rat biofluids and fetal tissue using highly sensitive analytical methods: assay validation and application to a pharmacokinetic study

2007 ◽  
Vol 21 (6) ◽  
pp. 585-597 ◽  
Author(s):  
Mahesh N. Samtani ◽  
William J. Jusko
Keyword(s):  
Pharmacokinetic Study ◽  
Analytical Methods ◽  
Fetal Tissue ◽  
Assay Validation ◽  
Highly Sensitive

Low fouling and ultrasensitive electrochemical immunosensors with dual assay methods based on Fe3O4 magnetic nanoparticles

2019 ◽  
Vol 7 (38) ◽  
pp. 5842-5847 ◽  
Author(s):  
Wenshi Li ◽  
Gao-Chao Fan ◽  
Xiaojian Fan ◽  
Ruiqiao Zhang ◽  
Lei Wang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Analytical Methods ◽  
Sensitive Detection ◽  
Fe3o4 Magnetic Nanoparticles ◽  
Cancer Antigen ◽  
Electrochemical Immunosensors ◽  
Highly Sensitive ◽  
Assay Methods ◽  
Highly Sensitive Detection

Low fouling electrochemical immunosensors for the highly sensitive detection of cancer antigen 15-3 with both “signal-off” and “signal-on” analytical methods were developed.

scholarly journals Coelenterazine-Dependent Luciferases as a Powerful Analytical Tool for Research and Biomedical Applications

2020 ◽  
Vol 21 (20) ◽  
pp. 7465 ◽  
Author(s):  
Vasilisa V. Krasitskaya ◽  
Eugenia E. Bashmakova ◽  
Ludmila A. Frank
Keyword(s):  
Analytical Methods ◽  
Analytical Tool ◽  
Biological Research ◽  
Research Areas ◽  
Enzyme Substrate ◽  
Highly Sensitive ◽  
Powerful Analytical Tool ◽  
Fundamental Research ◽  
Common Group ◽  
First Time

The functioning of bioluminescent systems in most of the known marine organisms is based on the oxidation reaction of the same substrate—coelenterazine (CTZ), catalyzed by luciferase. Despite the diversity in structures and the functioning mechanisms, these enzymes can be united into a common group called CTZ-dependent luciferases. Among these, there are two sharply different types of the system organization—Ca2+-regulated photoproteins and luciferases themselves that function in accordance with the classical enzyme–substrate kinetics. Along with deep and comprehensive fundamental research on these systems, approaches and methods of their practical use as highly sensitive reporters in analytics have been developed. The research aiming at the creation of artificial luciferases and synthetic CTZ analogues with new unique properties has led to the development of new experimental analytical methods based on them. The commercial availability of many ready-to-use assay systems based on CTZ-dependent luciferases is also important when choosing them by first-time-users. The development of analytical methods based on these bioluminescent systems is currently booming. The bioluminescent systems under consideration were successfully applied in various biological research areas, which confirms them to be a powerful analytical tool. In this review, we consider the main directions, results, and achievements in research involving these luciferases.

HIGHLY SENSITIVE LC-MS/MS METHOD FOR THE DETERMINATION OF CLOZAPINE IN RAT PLASMA: APPLICATION TO A PRECLINICAL PHARMACOKINETIC STUDY

2012 ◽  
Vol 35 (20) ◽  
pp. 2873-2883 ◽  
Author(s):  
Sandra Elisa Haas ◽  
Liberato Brum ◽  
Cristiane de Andrade ◽  
Francine Johansson Azeredo ◽  
Maiara Pigatto ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Highly Sensitive

Highly sensitive LC-MS/MS-ESI method for simultaneous quantitation of albendazole and ricobendazole in rat plasma and its application to a rat pharmacokinetic study

2011 ◽  
Vol 26 (2) ◽  
pp. 247-255 ◽  
Author(s):  
Kuldeep Sharma ◽  
Murugesh Kandaswamy ◽  
Chandan Mithra ◽  
Ashok Kumar Meena ◽  
Sanjeev Giri ◽  
...  
Keyword(s):  
Pharmacokinetic Study ◽  
Rat Plasma ◽  
Highly Sensitive
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