Nine absorbed components pharmacokinetic of raw and processed Moutan Cortex in normal and blood‐heat and hemorrhage syndrome model rats

2020 ◽  
Vol 34 (12) ◽  
Author(s):  
Qiuli Ye ◽  
Pei Cheng ◽  
Donghui Yan ◽  
Yue Sun ◽  
Ying Zhang ◽  
...  
Keyword(s):  
Moutan Cortex

scholarly journals Galloyl-oxypaeoniflorin, suffruticosides A, B, C, and D, five new antioxidative glycosides, and suffruticoside E, a paeonol glycoside, from Chinese Moutan Cortex.

1992 ◽  
Vol 40 (8) ◽  
pp. 2248-2250 ◽  
Author(s):  
Masayuki YOSHIKAWA ◽  
Emiko UCHIDA ◽  
Atsuhiro KAWAGUCHI ◽  
Isao KITAGAWA ◽  
Johji YAMAHARA
Keyword(s):  
Moutan Cortex

Analgesic effect of extracts of Chinese medicinal herbs Moutan cortex and Coicis semen on neuropathic pain in mice

2004 ◽  
Vol 370 (2-3) ◽  
pp. 130-134 ◽  
Author(s):  
Shinichi Tatsumi ◽  
Tamaki Mabuchi ◽  
Tetsuya Abe ◽  
Li Xu ◽  
Toshiaki Minami ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Analgesic Effect ◽  
Medicinal Herbs ◽  
Chinese Medicinal Herbs ◽  
Moutan Cortex

scholarly journals Specificity Screening of Potential Active Components from Moutan Cortex for Rat Mesangial Cells HBZY-1 by Cell Membrane Immobilized Chromatography

2015 ◽  
Vol 06 (02) ◽  
pp. 147-157
Author(s):  
Junfei Gu ◽  
Minghua Zhang ◽  
Jiarui Yuan ◽  
Bingjie Zhao ◽  
Liang Feng ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Mesangial Cells ◽  
Active Components ◽  
Moutan Cortex

Paeonol attenuates airway inflammation and hyperresponsiveness in a murine model of ovalbumin-induced asthma

2010 ◽  
Vol 88 (10) ◽  
pp. 1010-1016 ◽  
Author(s):  
Qiang Du ◽  
Gan-Zhu Feng ◽  
Li Shen ◽  
Jin Cui ◽  
Jian-Kang Cai
Keyword(s):  
Bronchoalveolar Lavage ◽  
Airway Inflammation ◽  
Bronchoalveolar Lavage Fluid ◽  
Immunoglobulin E ◽  
Therapeutic Potential ◽  
Lavage Fluid ◽  
Interleukin 4 ◽  
Moutan Cortex ◽  
Ifn Γ ◽  
Anti Inflammatory

Paeonol, the main active component isolated from Moutan Cortex, possesses extensive pharmacological activities such as anti-inflammatory, anti-allergic, and immunoregulatory effects. In the present study, we examined the effects of paeonol on airway inflammation and hyperresponsiveness in a mouse model of allergic asthma. BALB/c mice sensitized and challenged with ovalbumin were administered paeonol intragastrically at a dose of 100 mg/kg daily. Paeonol significantly suppressed ovalbumin-induced airway hyperresponsiveness to acetylcholine chloride. Paeonol administration significantly inhibited the total inflammatory cell and eosinophil count in bronchoalveolar lavage fluid. Treatment with paeonol significantly enhanced IFN-γ levels and decreased interleukin-4 and interleukin-13 levels in bronchoalveolar lavage fluid and total immunoglobulin E levels in serum. Histological examination of lung tissue demonstrated that paeonol significantly attenuated allergen-induced lung eosinophilic inflammation and mucus-producing goblet cells in the airway. These data suggest that paeonol exhibits anti-inflammatory activity in allergic mice and may possess new therapeutic potential for the treatment of allergic bronchial asthma.

scholarly journals A Network Pharmacology Approach Used to Estimate the Active Ingredients of Moutan Cortex Charcoal and the Potential Targets in Hemorrhagic Diseases

2019 ◽  
Vol 42 (3) ◽  
pp. 432-441 ◽  
Author(s):  
Shuiqing Li ◽  
Xingyang Xue ◽  
Xiaolu Yang ◽  
Sujuan Zhou ◽  
Shumei Wang ◽  
...  
Keyword(s):  
Network Pharmacology ◽  
Active Ingredients ◽  
Moutan Cortex

scholarly journals Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Liyan Mei ◽  
Meihong He ◽  
Chaoying Zhang ◽  
Jifei Miao ◽  
Quan Wen ◽  
...  
Keyword(s):  
Quantitative Polymerase Chain Reaction ◽  
Chinese Herb ◽  
Cecal Ligation ◽  
Underlying Mechanism ◽  
Raw264.7 Cells ◽  
Enzyme Linked Immunosorbent Assay ◽  
Life Threatening ◽  
Moutan Cortex ◽  
Anti Inflammatory

AbstractSepsis is a life-threatening disease caused by infection. Inflammation is a key pathogenic process in sepsis. Paeonol, an active ingredient in moutan cortex (a Chinese herb), has many pharmacological activities, such as anti-inflammatory and antitumour actions. Previous studies have indicated that paeonol inhibits the expression of HMGB1 and the transcriptional activity of NF-κB. However, its underlying mechanism is still unknown. In this study, microarray assay and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) results confirmed that paeonol could significantly up-regulate the expression of miR-339-5p in RAW264.7 cells stimulated by LPS. Dual-luciferase assays indicated that miR-339-5p interacted with the 3′ untranslated region (3′-UTR) of HMGB1. Western blot, immunofluorescence and enzyme-linked immunosorbent assay (ELISA) analyses indicated that miR-339-5p mimic and siHMGB1 both negatively regulated the expression and secretion of inflammatory cytokines (e.g., HMGB1, IL-1β and TNF-α) in LPS-induced RAW264.7 cells. Studies have confirmed that IKK-β is targeted by miR-339-5p, and we further found that paeonol could inhibit IKK-β expression. Positive mutual feedback between HMGB1 and IKK-β was observed when we silenced HMGB1 or IKK-β. These results indicated that paeonol could attenuate the inflammation mediated by HMGB1 and IKK-β by upregulating miR-339-5p expression. In addition, we constructed CLP model mice by cecal ligation and puncture. Paeonol was used to intervene to investigate its anti-inflammatory effect in vivo. The results showed that paeonol could improve the survival rate of sepsis mice and protect the kidney of sepsis mice.

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