scholarly journals Galloyl-oxypaeoniflorin, suffruticosides A, B, C, and D, five new antioxidative glycosides, and suffruticoside E, a paeonol glycoside, from Chinese Moutan Cortex.

1992 ◽  
Vol 40 (8) ◽  
pp. 2248-2250 ◽  
Author(s):  
Masayuki YOSHIKAWA ◽  
Emiko UCHIDA ◽  
Atsuhiro KAWAGUCHI ◽  
Isao KITAGAWA ◽  
Johji YAMAHARA
Keyword(s):  
Moutan Cortex

Analgesic effect of extracts of Chinese medicinal herbs Moutan cortex and Coicis semen on neuropathic pain in mice

2004 ◽  
Vol 370 (2-3) ◽  
pp. 130-134 ◽  
Author(s):  
Shinichi Tatsumi ◽  
Tamaki Mabuchi ◽  
Tetsuya Abe ◽  
Li Xu ◽  
Toshiaki Minami ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Analgesic Effect ◽  
Medicinal Herbs ◽  
Chinese Medicinal Herbs ◽  
Moutan Cortex

scholarly journals Specificity Screening of Potential Active Components from Moutan Cortex for Rat Mesangial Cells HBZY-1 by Cell Membrane Immobilized Chromatography

2015 ◽  
Vol 06 (02) ◽  
pp. 147-157
Author(s):  
Junfei Gu ◽  
Minghua Zhang ◽  
Jiarui Yuan ◽  
Bingjie Zhao ◽  
Liang Feng ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Mesangial Cells ◽  
Active Components ◽  
Moutan Cortex

Paeonol attenuates airway inflammation and hyperresponsiveness in a murine model of ovalbumin-induced asthma

2010 ◽  
Vol 88 (10) ◽  
pp. 1010-1016 ◽  
Author(s):  
Qiang Du ◽  
Gan-Zhu Feng ◽  
Li Shen ◽  
Jin Cui ◽  
Jian-Kang Cai
Keyword(s):  
Bronchoalveolar Lavage ◽  
Airway Inflammation ◽  
Bronchoalveolar Lavage Fluid ◽  
Immunoglobulin E ◽  
Therapeutic Potential ◽  
Lavage Fluid ◽  
Interleukin 4 ◽  
Moutan Cortex ◽  
Ifn Γ ◽  
Anti Inflammatory

Paeonol, the main active component isolated from Moutan Cortex, possesses extensive pharmacological activities such as anti-inflammatory, anti-allergic, and immunoregulatory effects. In the present study, we examined the effects of paeonol on airway inflammation and hyperresponsiveness in a mouse model of allergic asthma. BALB/c mice sensitized and challenged with ovalbumin were administered paeonol intragastrically at a dose of 100 mg/kg daily. Paeonol significantly suppressed ovalbumin-induced airway hyperresponsiveness to acetylcholine chloride. Paeonol administration significantly inhibited the total inflammatory cell and eosinophil count in bronchoalveolar lavage fluid. Treatment with paeonol significantly enhanced IFN-γ levels and decreased interleukin-4 and interleukin-13 levels in bronchoalveolar lavage fluid and total immunoglobulin E levels in serum. Histological examination of lung tissue demonstrated that paeonol significantly attenuated allergen-induced lung eosinophilic inflammation and mucus-producing goblet cells in the airway. These data suggest that paeonol exhibits anti-inflammatory activity in allergic mice and may possess new therapeutic potential for the treatment of allergic bronchial asthma.

scholarly journals A Network Pharmacology Approach Used to Estimate the Active Ingredients of Moutan Cortex Charcoal and the Potential Targets in Hemorrhagic Diseases

2019 ◽  
Vol 42 (3) ◽  
pp. 432-441 ◽  
Author(s):  
Shuiqing Li ◽  
Xingyang Xue ◽  
Xiaolu Yang ◽  
Sujuan Zhou ◽  
Shumei Wang ◽  
...  
Keyword(s):  
Network Pharmacology ◽  
Active Ingredients ◽  
Moutan Cortex

scholarly journals Paeonol attenuates inflammation by targeting HMGB1 through upregulating miR-339-5p

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Liyan Mei ◽  
Meihong He ◽  
Chaoying Zhang ◽  
Jifei Miao ◽  
Quan Wen ◽  
...  
Keyword(s):  
Quantitative Polymerase Chain Reaction ◽  
Chinese Herb ◽  
Cecal Ligation ◽  
Underlying Mechanism ◽  
Raw264.7 Cells ◽  
Enzyme Linked Immunosorbent Assay ◽  
Life Threatening ◽  
Moutan Cortex ◽  
Anti Inflammatory

AbstractSepsis is a life-threatening disease caused by infection. Inflammation is a key pathogenic process in sepsis. Paeonol, an active ingredient in moutan cortex (a Chinese herb), has many pharmacological activities, such as anti-inflammatory and antitumour actions. Previous studies have indicated that paeonol inhibits the expression of HMGB1 and the transcriptional activity of NF-κB. However, its underlying mechanism is still unknown. In this study, microarray assay and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) results confirmed that paeonol could significantly up-regulate the expression of miR-339-5p in RAW264.7 cells stimulated by LPS. Dual-luciferase assays indicated that miR-339-5p interacted with the 3′ untranslated region (3′-UTR) of HMGB1. Western blot, immunofluorescence and enzyme-linked immunosorbent assay (ELISA) analyses indicated that miR-339-5p mimic and siHMGB1 both negatively regulated the expression and secretion of inflammatory cytokines (e.g., HMGB1, IL-1β and TNF-α) in LPS-induced RAW264.7 cells. Studies have confirmed that IKK-β is targeted by miR-339-5p, and we further found that paeonol could inhibit IKK-β expression. Positive mutual feedback between HMGB1 and IKK-β was observed when we silenced HMGB1 or IKK-β. These results indicated that paeonol could attenuate the inflammation mediated by HMGB1 and IKK-β by upregulating miR-339-5p expression. In addition, we constructed CLP model mice by cecal ligation and puncture. Paeonol was used to intervene to investigate its anti-inflammatory effect in vivo. The results showed that paeonol could improve the survival rate of sepsis mice and protect the kidney of sepsis mice.

Moutan Cortex Radicis inhibits inflammatory changes of gene expression in lipopolysaccharide-stimulated gingival fibroblasts

2012 ◽  
Vol 67 (3) ◽  
pp. 576-589 ◽  
Author(s):  
Cheol-Sang Yun ◽  
Yeong-Gon Choi ◽  
Mi-Young Jeong ◽  
Je-Hyun Lee ◽  
Sabina Lim
Keyword(s):  
Gene Expression ◽  
Gingival Fibroblasts ◽  
Moutan Cortex ◽  
Inflammatory Changes
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