Influence of pH and organic modifiers on the dissociation constants of selected drugs using reversed‐phase thin‐layer chromatography: Comparison with other techniques and computational tools

2019 ◽  
Author(s):  
Nejal M. Bhatt ◽  
Vijay D. Chavada ◽  
Mallika Sanyal ◽  
Pranav S. Shrivastav
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Dissociation Constants ◽  
Reversed Phase ◽  
Organic Modifiers ◽  
Computational Tools ◽  
Layer Chromatography ◽  
Influence Of Ph

scholarly journals STUDYING OF THE LIPOPHILICITY AND TOXICITY OF DIPHENYLACETAMIDE DERIVATIVES

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Suzana Apostolov ◽  
Đenđi Vaštag ◽  
Borko Matijević ◽  
Gorana Mrđan
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Reversed Phase ◽  
Biologically Active ◽  
Log P ◽  
Organic Modifiers ◽  
Modern Approach ◽  
Software Packages ◽  
Test Organisms ◽  
Layer Chromatography

Modern approach in the study of biologically active compounds includes the establishment of relationships between molecular structure, physicochemical properties and the behavior which studied compound can manifest in the biological medium. These examinantions are performed in the early stages of the design of future bioactive agent and require the knowledge of molecular descriptors that can point to its biological activity, including lipophilicity which occupies a key position. For the series of diphenylacetamide derivatives, lipophilicity is determined experimentally by thin-layer chromatography on reversed phase (RP TLC18 F254s), in mixtures of water and various organic modifiers and computationally, by using the relevant software packages. In order to estimate the potential acute toxicity of the tested diphenylacetamide derivatives, their effective concentrations, EC50, on the selected test organisms have been determined. Experimentally determined lipophilicity (RM 0 and m) is correlated with a standard measure of lipophilicity (log P), as well as with the selected parameters of toxicity. Thus it has been found that thin-layer chromatography on reversed phase can be used reliably for describing the lipophilicity and for the evaluation of the toxic effects of diphenylacetamide derivatives.

Reversed-phase thin-layer chromatography of some foodstuff dyes

2003 ◽  
Vol 16 (4) ◽  
pp. 276-279 ◽  
Author(s):  
Dušanka Milojković-Opsenica ◽  
Kristina Lazarević ◽  
Vojkan Ivačković ◽  
Živoslav Tešić
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Reversed Phase ◽  
Layer Chromatography

Chromo-ionophoric Properties of para-(5-phthalhydrazide-azo)-phenylene-N-aza-15-crown-5 in the Presence of Lithium and Sodium Ions

2008 ◽  
Vol 59 (10) ◽  
Author(s):  
Rodica Daniela Baratoiu ◽  
Radu Socoteanu ◽  
Radu Cristian Mutihac ◽  
Anca Elena Barbu ◽  
Adrian Beteringhe ◽  
...  
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Reversed Phase ◽  
Complex Stability ◽  
Sodium Ions ◽  
Layer Chromatography

Investigations on the hydrophobic and ionophoric character of para-(5-phthalhydrazide-azo)-phenylene-N-aza-15-crown- (1) were carried out by reversed phase thin layer chromatography (RP-TLC) and spectrophotometric measurements. The study included complexes with Li+ and Na+ cations (as perchlorates in acetonitrile and as dibenzyldithiocarbamate salts in chloroform). In both cases, the stoichiometry of complexes was 1:1:1 (1:M+:anion pair). The complex stability (logKS ) is similar.

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