Synthesis and biological evaluation of dimeric peptide derivatives as proliferation‐stimulating agents in human follicle dermal papilla cells

2021 ◽  
Author(s):  
Jisu Jeong ◽  
Kyeong‐Yong Park ◽  
Jiyeon Kim
Keyword(s):  
Dermal Papilla ◽  
Biological Evaluation ◽  
Dermal Papilla Cells ◽  
Peptide Derivatives ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of peptide derivatives of l-dopa as anti-parkinsonian agents

2013 ◽  
Vol 23 (19) ◽  
pp. 5279-5282 ◽  
Author(s):  
Tao Zhou ◽  
Robert C. Hider ◽  
Peter Jenner ◽  
Bruce Campbell ◽  
Christopher J. Hobbs ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Peptide Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

Synthesis and biological evaluation of a novel series of curcumin-peptide derivatives as PepT1-mediated transport drugs

2019 ◽  
Vol 92 ◽  
pp. 103163 ◽  
Author(s):  
Jiyun Zhang ◽  
Hongmei Wen ◽  
Fei Shen ◽  
Xinzhi Wang ◽  
Chenxiao Shan ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Peptide Derivatives ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of immunostimulating mannosylated desmuramyl peptides

2019 ◽  
Vol 15 ◽  
pp. 1805-1814 ◽  
Author(s):  
Rosana Ribić ◽  
Ranko Stojković ◽  
Lidija Milković ◽  
Mariastefania Antica ◽  
Marko Cigler ◽  
...  
Keyword(s):  
Muramyl Dipeptide ◽  
Biological Evaluation ◽  
Adjuvant Activity ◽  
Design Synthesis ◽  
C Terminus ◽  
Minimal Structure ◽  
Dipeptide Analogues ◽  
Peptide Derivatives ◽  
Mannose Receptors ◽  
Synthesis And Biological Evaluation

Muramyl dipeptide is the minimal structure of peptidoglycan with adjuvant properties. Replacement of the N-acetylmuramyl moiety and increase of lipophilicity are important approaches in the preparation of muramyl dipeptide analogues with improved pharmacological properties. Mannose receptors present on immunocompetent cells are pattern-recognition receptors and by mannose ligands binding they affect the immune system. Here we present the design, synthesis and biological evaluation of novel mannosylated desmuramyl peptide derivatives. Mannose was coupled to dipeptides containing a lipophilic adamantane on N- or C-terminus through a glycolyl or hydroxyisobutyryl linker. Adjuvant activities of synthesized compounds were investigated in the mouse model using ovalbumin as an antigen. Their activities were compared to the previously described mannosylated adamantane-containing desmuramyl peptide and peptidoglycan monomer. Tested compounds exhibited adjuvant activity and the strongest enhancement of IgG production was stimulated by compound 21 (Man-OCH2-ᴅ-(1-Ad)Gly-ʟ-Ala-ᴅ-isoGln).

scholarly journals SYNTHESIS AND BIOLOGICAL EVALUATION OF NICOTINIC ACID PEPTIDE DERIVATIVES

2019 ◽  
Vol 8 (4) ◽  
Author(s):  
Nisha Dhir ◽  
Gagan Preet Kaur
Keyword(s):  
Antimicrobial Activity ◽  
Nicotinic Acid ◽  
Biological Activities ◽  
Methyl Esters ◽  
Biological Evaluation ◽  
E Coli ◽  
Peptide Derivatives ◽  
Rf Values ◽  
Antibacterial And Antifungal ◽  
Synthesis And Biological Evaluation

The present study deals with the synthesis of nicotinic acid peptide derivatives and comparative evaluation of biological activities, such as antibacterial and antifungal. Among hetrocyclic aromatic compounds, pyridine nucleus is found in many bioactive products and incorporation of amino acids and peptides into the hetrocyclic aromatic congeners have resulted in compounds with potent activities. All the compounds were synthesized by coupling of nicotinic acids with amino acid methyl esters/dipeptides/tripeptides/tetrapeptides in presence of DCC as coupling agent and NMM as base under continuous stirring for 36 hrs. All synthesized peptide derivatives were identified on the basis of melting point range, Rf values, solubility studies, IR and 1H NMR spectral data. The antimicrobial activity of synthesized compounds was determined against bacterial strainsviz. E. Coli and S. Aureus and fungal strains viz. C. albicans and A. Niger using ciprofloxacin and fluconazole as standard respectively. All the synthesized compounds showed good to moderate antimicrobial activity at 40, 80 and 160 μg/ml. The comparative studies showed the following order of activity profile: nicotinic acid <nicotinic acid methylesters>dipeptide >tripeptide>tetrapeptide. Keywords: Nicotinic acid, Peptides, Antimicrobial activity.

scholarly journals Design, synthesis and biological evaluation of immunostimulating mannosylated desmuramyl peptides

2019 ◽  
Author(s):  
Rosana Ribić ◽  
Ranko Stojković ◽  
Lidija Milković ◽  
Mariastefania Antica ◽  
Marko Cigler ◽  
...  
Keyword(s):  
Muramyl Dipeptide ◽  
Biological Evaluation ◽  
Adjuvant Activity ◽  
Design Synthesis ◽  
C Terminus ◽  
Minimal Structure ◽  
Dipeptide Analogues ◽  
Peptide Derivatives ◽  
Present Design ◽  
Synthesis And Biological Evaluation

Muramyl dipeptide is the minimal structure of peptidoglycan with adjuvant properties. Replacement of the N-acetylmuramyl moiety and increase of lipophilicity are important approaches in the preparation of muramyl dipeptide analogues with improved pharmacological properties. Mannose receptors present on immunocompetent cells are pattern-recognition receptors and by mannose ligands binding they affect the immune system. Here we present design, synthesis and biological evaluation of novel mannosylated desmuramyl peptide derivatives. Mannose was coupled to dipeptide containing lipophilic adamantane on N- or C-terminus through glycolyl or hydroxyisobutyryl linker. Adjuvant activities of synthesized compounds were investigated in the mouse model using ovalbumin as an antigen. Their activities were compared to the previously described mannosylated adamantane-containing desmuramyl peptide and peptidoglycan monomer. Tested compounds exhibited adjuvant activity and the strongest enhancement of IgG production was stimulated by the compound 21 (Man-OCH2-D-(1-Ad)Gly-L-Ala-D-isoGln).

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