Design, Synthesis and Biological Evaluation of Novel Tumor-Specific Antigenic Peptide Derivatives as Potential Vaccine Candidates with a Strong Affinity to HLA-A2

2019 ◽  
Author(s):  
Wei Shi ◽  
Qianqian Qiu ◽  
Zhenzhen Tong ◽  
Weiwei Guo ◽  
Feng Zou ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Antigenic Peptide ◽  
Design Synthesis ◽  
Vaccine Candidates ◽  
Strong Affinity ◽  
Peptide Derivatives ◽  
Potential Vaccine ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of peptide derivatives of l-dopa as anti-parkinsonian agents

2013 ◽  
Vol 23 (19) ◽  
pp. 5279-5282 ◽  
Author(s):  
Tao Zhou ◽  
Robert C. Hider ◽  
Peter Jenner ◽  
Bruce Campbell ◽  
Christopher J. Hobbs ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Peptide Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

scholarly journals Design, synthesis and biological evaluation of immunostimulating mannosylated desmuramyl peptides

2019 ◽  
Vol 15 ◽  
pp. 1805-1814 ◽  
Author(s):  
Rosana Ribić ◽  
Ranko Stojković ◽  
Lidija Milković ◽  
Mariastefania Antica ◽  
Marko Cigler ◽  
...  
Keyword(s):  
Muramyl Dipeptide ◽  
Biological Evaluation ◽  
Adjuvant Activity ◽  
Design Synthesis ◽  
C Terminus ◽  
Minimal Structure ◽  
Dipeptide Analogues ◽  
Peptide Derivatives ◽  
Mannose Receptors ◽  
Synthesis And Biological Evaluation

Muramyl dipeptide is the minimal structure of peptidoglycan with adjuvant properties. Replacement of the N-acetylmuramyl moiety and increase of lipophilicity are important approaches in the preparation of muramyl dipeptide analogues with improved pharmacological properties. Mannose receptors present on immunocompetent cells are pattern-recognition receptors and by mannose ligands binding they affect the immune system. Here we present the design, synthesis and biological evaluation of novel mannosylated desmuramyl peptide derivatives. Mannose was coupled to dipeptides containing a lipophilic adamantane on N- or C-terminus through a glycolyl or hydroxyisobutyryl linker. Adjuvant activities of synthesized compounds were investigated in the mouse model using ovalbumin as an antigen. Their activities were compared to the previously described mannosylated adamantane-containing desmuramyl peptide and peptidoglycan monomer. Tested compounds exhibited adjuvant activity and the strongest enhancement of IgG production was stimulated by compound 21 (Man-OCH2-ᴅ-(1-Ad)Gly-ʟ-Ala-ᴅ-isoGln).

scholarly journals Design, synthesis and biological evaluation of immunostimulating mannosylated desmuramyl peptides

2019 ◽  
Author(s):  
Rosana Ribić ◽  
Ranko Stojković ◽  
Lidija Milković ◽  
Mariastefania Antica ◽  
Marko Cigler ◽  
...  
Keyword(s):  
Muramyl Dipeptide ◽  
Biological Evaluation ◽  
Adjuvant Activity ◽  
Design Synthesis ◽  
C Terminus ◽  
Minimal Structure ◽  
Dipeptide Analogues ◽  
Peptide Derivatives ◽  
Present Design ◽  
Synthesis And Biological Evaluation

Muramyl dipeptide is the minimal structure of peptidoglycan with adjuvant properties. Replacement of the N-acetylmuramyl moiety and increase of lipophilicity are important approaches in the preparation of muramyl dipeptide analogues with improved pharmacological properties. Mannose receptors present on immunocompetent cells are pattern-recognition receptors and by mannose ligands binding they affect the immune system. Here we present design, synthesis and biological evaluation of novel mannosylated desmuramyl peptide derivatives. Mannose was coupled to dipeptide containing lipophilic adamantane on N- or C-terminus through glycolyl or hydroxyisobutyryl linker. Adjuvant activities of synthesized compounds were investigated in the mouse model using ovalbumin as an antigen. Their activities were compared to the previously described mannosylated adamantane-containing desmuramyl peptide and peptidoglycan monomer. Tested compounds exhibited adjuvant activity and the strongest enhancement of IgG production was stimulated by the compound 21 (Man-OCH2-D-(1-Ad)Gly-L-Ala-D-isoGln).

Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

2012 ◽  
Vol 9 (2) ◽  
pp. 140-152 ◽  
Author(s):  
Romeo Romagnoli ◽  
Pier Giovanni Baraldi ◽  
Olga Cruz-Lopez ◽  
Maria Kimatrai Salvador ◽  
Delia Preti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Hybrid Molecules ◽  
Synthesis And Biological Evaluation

Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4

2013 ◽  
Vol 10 (10) ◽  
pp. 935-941
Author(s):  
Yan Tang ◽  
Zhewei Tu ◽  
Jing Sun ◽  
Xiong Zhu ◽  
Kun Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of
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