scholarly journals Modulation of the central carbon metabolism of Corynebacterium glutamicum improves malonyl‐CoA availability and increases plant polyphenol synthesis

2019 ◽  
Vol 116 (6) ◽  
pp. 1380-1391 ◽  
Author(s):  
Lars Milke ◽  
Patrícia Ferreira ◽  
Nicolai Kallscheuer ◽  
Adelaide Braga ◽  
Michael Vogt ◽  
...  
Keyword(s):  
Corynebacterium Glutamicum ◽  
Carbon Metabolism ◽  
Central Carbon Metabolism ◽  
Malonyl Coa ◽  
Plant Polyphenol ◽  
Central Carbon

scholarly journals Investigation into the flux distribution of central carbon metabolism in Corynebacterium glutamicum using principal component analysis

2015 ◽  
Vol 67 (3) ◽  
pp. 767-774
Author(s):  
Chuanyu Shang ◽  
Xiangfei Zhou ◽  
Wenwei Zhou ◽  
Xiaoyao Xie ◽  
Yin Yi
Keyword(s):  
Corynebacterium Glutamicum ◽  
Carbon Metabolism ◽  
Flux Distribution ◽  
Environmental Changes ◽  
Principal Component ◽  
Central Carbon Metabolism ◽  
Preliminary Examination ◽  
Genetic Modifications ◽  
Central Carbon

Central carbon metabolism is the main source of energy required by organisms and it provides precursors for other in vivo metabolic processes. The flux flowing through the pathways involved in central carbon metabolism characterizes its biological function and genetic readout between species or environments. In recent years, using a 13C tracer technique, researchers have measured the flux of central carbon metabolism in Corynebacterium glutamicum under a variety of nutritional and environmental changes or genetic modifications. However, there is no integrated and comparative analysis of these measured flux values. In this study, the flux values of central carbon metabolism in Corynebacterium glutamicum that were obtained in other recent studies were consolidated. A preliminary examination of the distribution characteristics of flux values in each metabolic pathway was conducted and the regression relationship between different fluxes was investigated. The principal components of the flux vector were further extracted and aggregated based on the components, and the general features of flux distribution of central carbon metabolism as well as the influence of environmental and genetic factors on the flux distribution were determined. This study provides a foundation for further investigation into the flux distribution and regulation characteristics of central carbon metabolism.

scholarly journals Metformin Targets Central Carbon Metabolism and Reveals Mitochondrial Requirements in Human Cancers

2016 ◽  
Vol 24 (5) ◽  
pp. 728-739 ◽  
Author(s):  
Xiaojing Liu ◽  
Iris L. Romero ◽  
Lacey M. Litchfield ◽  
Ernst Lengyel ◽  
Jason W. Locasale
Keyword(s):  
Carbon Metabolism ◽  
Central Carbon Metabolism ◽  
Human Cancers ◽  
Central Carbon

Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism

2021 ◽  
Author(s):  
Colin C. Anderson ◽  
John O. Marentette ◽  
Kendra M. Prutton ◽  
Abhishek K. Rauniyar ◽  
Julie A. Reisz ◽  
...  
Keyword(s):  
Mitochondrial Function ◽  
Carbon Metabolism ◽  
Trisomy 21 ◽  
Central Carbon Metabolism ◽  
Central Carbon
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