Review: Bone tissue engineering: The role of interstitial fluid flow

1994 ◽  
Vol 43 (7) ◽  
pp. 573-581 ◽  
Author(s):  
M. V. Hillsley ◽  
J. A. Frangos
Keyword(s):  
Tissue Engineering ◽  
Fluid Flow ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Interstitial Fluid ◽  
Interstitial Fluid Flow

SIMULATION ON TISSUE DIFFERENTIATIONS FOR DIFFERENT ARCHITECTURE DESIGNS IN BONE TISSUE ENGINEERING SCAFFOLD BASED ON CELLULAR STRUCTURE MODEL

2015 ◽  
Vol 15 (03) ◽  
pp. 1550028 ◽  
Author(s):  
XIANBIN ZHANG ◽  
HE GONG
Keyword(s):  
Tissue Engineering ◽  
Fluid Flow ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Compressive Loading ◽  
Three Dimensional ◽  
Mechanical Stimuli ◽  
Interstitial Fluid Flow ◽  
Unconfined Compression Test ◽  
Defect Sites

In bone tissue engineering, mechanical stimuli are among the key factors affecting cell proliferation and differentiation. This study aimed to investigate the effects of different inlet fluid velocities and axial strains on the differentiation of bone marrow mesenchymal stem cells (BMSCs) on the surface of scaffolds with different morphologies. Five three-dimensional bone scaffold architectures with 65% porosity were designed using typical cellular structural models of trabecular bone. Apparent compressive strains between 0% and 5% were applied to simulate an unconfined compression test. Strain distributions were analyzed on the wall surface of the solid model. The interstitial fluid flow at inlet velocities ranging between 0.01 mm/s and 1 mm/s was applied to interconnected pores, simulating a steady state flow in the scaffold. The shear stress distributions on the surface of the scaffolds were calculated. The differentiation of BMSCs on the surface of the scaffolds with different morphologies was predicted according to mechanoregulation theory. This study shows that different levels of mechanical stimuli can be generated as a result of different scaffold morphologies under compressive loading and fluid flow to satisfy the mechanical requirements for different bone defect sites.

scholarly journals The Regenerative Applicability of Bioactive Glass and Beta-Tricalcium Phosphate in Bone Tissue Engineering: A Transformation Perspective

2019 ◽  
Vol 10 (1) ◽  
pp. 16 ◽  
Author(s):  
Baboucarr Lowe ◽  
Mark P. Ottensmeyer ◽  
Chun Xu ◽  
Yan He ◽  
Qingsong Ye ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bioactive Glass ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Beta Tricalcium Phosphate ◽  
Engineering Strategy

The conventional applicability of biomaterials in the field of bone tissue engineering takes into consideration several key parameters to achieve desired results for prospective translational use. Hence, several engineering strategies have been developed to model in the regenerative parameters of different forms of biomaterials, including bioactive glass and β-tricalcium phosphate. This review examines the different ways these two materials are transformed and assembled with other regenerative factors to improve their application for bone tissue engineering. We discuss the role of the engineering strategy used and the regenerative responses and mechanisms associated with them.

scholarly journals The Role of Interstitial Fluid Flow in the Remodeling Response to Fatigue Loading

2002 ◽  
Vol 17 (11) ◽  
pp. 2030-2037 ◽  
Author(s):  
A. E. Tami ◽  
P. Nasser ◽  
O. Verborgt ◽  
M. B. Schaffler ◽  
M. L. Knothe Tate
Keyword(s):  
Fluid Flow ◽  
Interstitial Fluid ◽  
Fatigue Loading ◽  
Interstitial Fluid Flow

scholarly journals Scaffolds Based Bone Tissue Engineering: The Role of Chitosan

2011 ◽  
Vol 17 (5) ◽  
pp. 331-347 ◽  
Author(s):  
Ana Rita Costa-Pinto ◽  
Rui L. Reis ◽  
Nuno M. Neves
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue

Numerical Study of Granular Scaffold Efficiency to Convert Fluid Flow into Mechanical Stimulation in Bone Tissue Engineering

2015 ◽  
Vol 21 (9) ◽  
pp. 863-871 ◽  
Author(s):  
Magali Cruel ◽  
Morad Bensidhoum ◽  
Cécile Nouguier-Lehon ◽  
Olivier Dessombz ◽  
Pierre Becquart ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Fluid Flow ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Mechanical Stimulation ◽  
Numerical Study

The role of osteoclasts in bone tissue engineering

2014 ◽  
Vol 9 (10) ◽  
pp. 1133-1149 ◽  
Author(s):  
Rainer Detsch ◽  
Aldo R. Boccaccini
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue
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