Protease-catalyzed peptide synthesis using inverse substrates: The influence of reaction conditions on the trypsin acyl transfer efficiency

1991 ◽  
Vol 38 (1) ◽  
pp. 104-108 ◽  
Author(s):  
Volker Schellenberger ◽  
Hans-Dieter Jakubke ◽  
Nina P. Zapevalova ◽  
Yuri V. Mitin
Keyword(s):  
Peptide Synthesis ◽  
Acyl Transfer ◽  
Transfer Efficiency ◽  
Reaction Conditions

Acetal Formation Facilitated in 2-Hydroxyaryl Aldehydes by Intramolecular Acyl Group Transfer

1986 ◽  
Vol 39 (11) ◽  
pp. 1747 ◽  
Author(s):  
AJ Liepa ◽  
AJ Liepa ◽  
TC Morton ◽  
TC Morton
Keyword(s):  
Acyl Transfer ◽  
Reaction Conditions ◽  
Group Transfer ◽  
Acetyl Group ◽  
Derivatives Of ◽  
Acyl Derivatives ◽  
Mechanism Of The Reaction

Convenient preparations of synthetically useful acetals, a dithioacetal and an oxathiolan from the 2-acyl derivatives of 2-hydroxyaryl aldehydes under basic conditions are described. The mildness of the reaction conditions is illustrated by the formation of an ethoxycarbonyl -substituted dioxolan . The reaction is dependent upon an intramolecular acetyl group transfer and the mechanism of the reaction is discussed. Some broader implications of this type of acyl transfer are discussed.

Applications of Chemical Ligation in Peptide Synthesis via Acyl Transfer

2014 ◽  
pp. 229-265 ◽  
Author(s):  
Siva S. Panda ◽  
Rachel A. Jones ◽  
C. Dennis Hall ◽  
Alan R. Katritzky
Keyword(s):  
Peptide Synthesis ◽  
Acyl Transfer ◽  
Chemical Ligation

Derivatized Amino Acids Relevant to Native Peptide Synthesis by Chemical Ligation and Acyl Transfer

2003 ◽  
Vol 68 (24) ◽  
pp. 9247-9254 ◽  
Author(s):  
Derrick L. J. Clive ◽  
Soleiman Hisaindee ◽  
Don M. Coltart
Keyword(s):  
Amino Acids ◽  
Peptide Synthesis ◽  
Acyl Transfer ◽  
Chemical Ligation ◽  
Native Peptide

scholarly journals Organocatalytic Asymmetric Michael/Acyl Transfer Reaction between α-Nitroketones and 4-Arylidene- pyrrolidine-2,3-diones

2021 ◽  
Author(s):  
Chandrakanta Parida ◽  
Subhas C Pan
Keyword(s):  
Transfer Reaction ◽  
Acyl Transfer ◽  
Reaction Conditions ◽  
Acyl Transfer Reaction

An organocatalytic asymmetric Michael/acyl transfer reaction between α-nitroketones and 4-arylidene-pyrrolidine-2,3-diones was reported. Bifunctional thiourea catalyst was found to be effective for this reaction. With 10 mol% of the catalyst, good results were attained for a variety of 1,5-dihydro-2H-pyrrol-2-ones under mild reaction conditions.

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