Mechanism of initial rapid rate retardation in cellobiohydrolase catalyzed cellulose hydrolysis

2010 ◽  
Vol 106 (6) ◽  
pp. 871-883 ◽  
Author(s):  
Jürgen Jalak ◽  
Priit Väljamäe
Author(s):  
Pan Hu ◽  
Huanan Li ◽  
Wenjing Xiao ◽  
Xiaohang Xie ◽  
Yuxian Yang ◽  
...  

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Pedro Freire Jorge ◽  
Rohan Boer ◽  
Rene A. Posma ◽  
Katharina C. Harms ◽  
Bart Hiemstra ◽  
...  

Abstract Objective Lactate has been shown to be preferentially metabolized in comparison to glucose after physiological stress, such as strenuous exercise. Derangements of lactate and glucose are common after out-of-hospital cardiac arrest (OHCA). Therefore, we hypothesized that lactate decreases faster than glucose after return-to-spontaneous-circulation (ROSC) after OHCA. Results We included 155 OHCA patients in our analysis. Within the first 8 h of presentation to the emergency department, 843 lactates and 1019 glucoses were available, respectively. Lactate decreased to 50% of its initial value within 1.5 h (95% CI [0.2–3.6 h]), while glucose halved within 5.6 h (95% CI [5.4–5.7 h]). Also, in the first 8 h after presentation lactate decreases more than glucose in relation to their initial values (lactate 72.6% vs glucose 52.1%). In patients with marked hyperlactatemia after OHCA, lactate decreased expediently while glucose recovered more slowly, whereas arterial pH recovered at a similar rapid rate as lactate. Hospital non-survivors (N = 82) had a slower recovery of lactate (P = 0.002) than survivors (N = 82). The preferential clearance of lactate underscores its role as a prime energy substrate, when available, during recovery from extreme stress.


2021 ◽  
Vol 490 ◽  
pp. 229537
Author(s):  
Sun Woong Baek ◽  
Kira E. Wyckoff ◽  
Danielle M. Butts ◽  
Jadon Bienz ◽  
Ampol Likitchatchawankun ◽  
...  
Keyword(s):  

Author(s):  
Ziyang Zhang ◽  
Geoffrey A Tompsett ◽  
Christopher Lambert ◽  
Sergio Granados-Focil ◽  
Michael T. Timko

Solid-acid catalysts functionalized with catalytic groups have attracted intense interests for hydrolyzing cellulose into fermentable compounds. However, the solid-acid catalysts design has been guided by molecular level of interactions and...


ACS Catalysis ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 1464-1468 ◽  
Author(s):  
Maksim Tyufekchiev ◽  
Pu Duan ◽  
Klaus Schmidt-Rohr ◽  
Sergio Granados Focil ◽  
Michael T. Timko ◽  
...  

AJIL Unbound ◽  
2017 ◽  
Vol 111 ◽  
pp. 272-276
Author(s):  
Jérôme de Hemptinne

In times of war, the first instinct is to relieve the suffering of human beings. Environmental and animal interests are always pushed into the background. However, warfare strongly affects natural resources, including animals, which makes animal issues a matter of great concern. Certain species have been vanishing at a rapid rate because of wars, often with disastrous effects on the food chain and on the ecological balance. Indeed, belligerents rarely take into account the adverse consequences of their military operations on animals. They even take advantage of the chaotic circumstances of war in order to poach protected species and to engage in the trafficking of expensive animal products. While generating billions of dollars each year, such poaching and trafficking allows armed groups to grow and to reinforce their authority over disputed territory. States have also trained, and continue to train, certain animals—principally marine mammals such as bottlenose dolphins and California sea lions—to perform military tasks, like ship and harbor protection, or mine detection and clearance. Millions of horses, mules, donkeys, camels, dogs, and birds are obliged to serve on various fronts (transport, logistics, or communications) and become particularly vulnerable targets.


Leukemia ◽  
2013 ◽  
Vol 28 (3) ◽  
pp. 713-716 ◽  
Author(s):  
V Vainstein ◽  
S A Buckley ◽  
O Shukron ◽  
E H Estey ◽  
J L Abkowitz ◽  
...  

2016 ◽  
Vol 52 (40) ◽  
pp. 6701-6704 ◽  
Author(s):  
Qing Sun ◽  
Wilfred Chen

We report here the generation of artificial cellulosomes onto a DNA scaffold using the self-labeling HaloTag for DNA conjugation. Rolling circle amplification multiplexing templates were used to increase the complexity of this system with higher efficiency observed.


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