Elucidation of metabolism in hybridoma cells grown in fed-batch culture by genome-scale modeling

Suresh Selvarasu; Victor V.T. Wong; Iftekhar A. Karimi; Dong-Yup Lee

doi:10.1002/bit.22186

Elucidation of metabolism in hybridoma cells grown in fed-batch culture by genome-scale modeling

Biotechnology and Bioengineering ◽

10.1002/bit.22186 ◽

2009 ◽

Vol 102 (5) ◽

pp. 1494-1504 ◽

Cited By ~ 18

Author(s):

Suresh Selvarasu ◽

Victor V.T. Wong ◽

Iftekhar A. Karimi ◽

Dong-Yup Lee

Keyword(s):

Batch Culture ◽

Hybridoma Cells ◽

Fed Batch ◽

Scale Modeling ◽

Fed Batch Culture ◽

Genome Scale

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Repeated fed-batch culture of hybridoma cells in nutrient-fortified high-density medium

Biotechnology and Bioengineering ◽

10.1002/bit.260421013 ◽

1993 ◽

Vol 42 (10) ◽

pp. 1229-1237 ◽

Cited By ~ 12

Author(s):

Eui-Cheol Jo ◽

Hae-Joon Park ◽

Dong-II Kim ◽

Hong Mo Moon

Keyword(s):

Batch Culture ◽

High Density ◽

Hybridoma Cells ◽

Fed Batch ◽

Fed Batch Culture

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Fed-batch culture of hybridoma cells: comparison of optimal control approach and closed loop strategies

Bioprocess Engineering ◽

10.1007/bf00389535 ◽

1993 ◽

Vol 9 (1) ◽

pp. 13-21 ◽

Cited By ~ 42

Author(s):

M. Tremblay ◽

M. Perrier ◽

C. Chavarie ◽

J. Archambault

Keyword(s):

Optimal Control ◽

Batch Culture ◽

Closed Loop ◽

Hybridoma Cells ◽

Fed Batch ◽

Control Approach ◽

Fed Batch Culture ◽

Optimal Control Approach

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A Serum Substitute for Fed-Batch Culture of Hybridoma Cells

Animal Cell Technology: Basic & Applied Aspects ◽

10.1007/978-1-4020-9646-4_12 ◽

2008 ◽

pp. 75-80

Author(s):

Keisuke Shibuya ◽

Ryoichi Haga ◽

Masaru Namba

Keyword(s):

Batch Culture ◽

Hybridoma Cells ◽

Fed Batch ◽

Fed Batch Culture ◽

Serum Substitute

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Optimization of Fed-batch Culture of Hybridoma Cells using Genetic Algorithms

Modelling and Optimization of Biotechnological Processes - Studies in Computational Intelligence ◽

10.1007/11550952_2 ◽

2006 ◽

pp. 17-27

Author(s):

Lei Zhi Chen ◽

Sing Kiong Nguang ◽

Xiao Dong Chen

Keyword(s):

Genetic Algorithms ◽

Batch Culture ◽

Hybridoma Cells ◽

Fed Batch ◽

Fed Batch Culture

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On-line Identification and Optimization of Feed Rate Profiles for Fed-batch Culture of Hybridoma Cells

Modelling and Optimization of Biotechnological Processes - Studies in Computational Intelligence ◽

10.1007/3-540-32493-3_3 ◽

2006 ◽

pp. 29-40

Keyword(s):

Batch Culture ◽

Feed Rate ◽

Hybridoma Cells ◽

Fed Batch ◽

Line Identification ◽

On Line ◽

Fed Batch Culture

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Ehancement of Antibody Productivity in the Near-Zero Specific Growth Rate During Glucose and Glutamine-Limited Fed-Batch Culture of Hybridoma Cells

Animal Cell Technology: Challenges for the 21st Century ◽

10.1007/0-306-46869-7_14 ◽

2005 ◽

pp. 75-79

Author(s):

J.D Jang ◽

J.P Barford

Keyword(s):

Growth Rate ◽

Specific Growth Rate ◽

Batch Culture ◽

Specific Growth ◽

Hybridoma Cells ◽

Fed Batch ◽

Antibody Productivity ◽

Fed Batch Culture

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On-line Identification and Optimization of Feed Rate Profiles for Fed-batch Culture of Hybridoma Cells

Modelling and Optimization of Biotechnological Processes - Studies in Computational Intelligence ◽

10.1007/11550952_3 ◽

2006 ◽

pp. 29-40

Author(s):

Lei Zhi Chen ◽

Sing Kiong Nguang ◽

Xiao Dong Chen

Keyword(s):

Batch Culture ◽

Feed Rate ◽

Hybridoma Cells ◽

Fed Batch ◽

Line Identification ◽

On Line ◽

Fed Batch Culture

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Online identification and optimization of feed rate profiles for high productivity fed-batch culture of hybridoma cells using genetic algorithms

Proceedings of the 2001 American Control Conference. (Cat. No.01CH37148) ◽

10.1109/acc.2001.946234 ◽

2001 ◽

Author(s):

Lei Zhi Chen ◽

Sing Kiong Nguang ◽

Xiao Dong Chen

Keyword(s):

Genetic Algorithms ◽

Batch Culture ◽

Feed Rate ◽

Hybridoma Cells ◽

Fed Batch ◽

High Productivity ◽

Online Identification ◽

Fed Batch Culture

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Control of Fed-Batch Culture of Hybridoma Cells for Monoclonal Antibody Production

10.23919/acc.1990.4791111 ◽

1990 ◽

Cited By ~ 1

Author(s):

Michele de Tremblay ◽

Michel Perrier ◽

Claude Chavarie ◽

Jean Archambault

Keyword(s):

Monoclonal Antibody ◽

Batch Culture ◽

Antibody Production ◽

Hybridoma Cells ◽

Fed Batch ◽

Monoclonal Antibody Production ◽

Fed Batch Culture

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Combined data preprocessing and multivariate statistical analysis characterizes fed-batch culture of mouse hybridoma cells for rational medium design

Journal of Biotechnology ◽

10.1016/j.jbiotec.2010.07.016 ◽

2010 ◽

Vol 150 (1) ◽

pp. 94-100 ◽

Cited By ~ 20

Author(s):

Suresh Selvarasu ◽

Do Yun Kim ◽

Iftekhar A. Karimi ◽

Dong-Yup Lee

Keyword(s):

Statistical Analysis ◽

Batch Culture ◽

Multivariate Statistical Analysis ◽

Data Preprocessing ◽

Hybridoma Cells ◽

Fed Batch ◽

Multivariate Statistical ◽

Medium Design ◽

Fed Batch Culture ◽

Combined Data

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