Reversibility of acid denaturation of recombinant interferon-?

Biopolymers ◽  
1990 ◽  
Vol 29 (6-7) ◽  
pp. 1065-1068 ◽  
Author(s):  
Tsutomu Arakawa ◽  
Yeuh-Rong Hsu ◽  
Michael A. Narachi ◽  
Charles Herrera ◽  
Michael F. Rohde ◽  
...  
Keyword(s):  
Recombinant Interferon ◽  
Acid Denaturation

Production of interferon by red deer (Cervus elaphus) conceptuses and the effects of roIFN-tau on the timing of luteolysis and the success of asynchronous embryo transfer

Reproduction ◽  
2000 ◽  
pp. 387-395 ◽  
Author(s):  
KJ Demmers ◽  
HN Jabbour ◽  
DW Deakin ◽  
AP Flint
Keyword(s):  
Embryo Transfer ◽  
Early Pregnancy ◽  
Cervus Elaphus ◽  
Pregnancy Loss ◽  
Red Deer ◽  
Interferon Tau ◽  
Recombinant Interferon ◽  
Uterine Flushing ◽  
Calving Rate

The role of interferon in early pregnancy in red deer was investigated by (a) measuring production of interferon by the conceptus, (b) testing the anti-luteolytic effect of recombinant interferon-tau in non-pregnant hinds, and (c) treatment of hinds with interferon after asynchronous embryo transfer. Blastocysts were collected from 34 hinds by uterine flushing 14 (n = 2), 16 (n = 2), 18 (n = 8), 20 (n = 13) or 22 (n = 9) days after synchronization of oestrus with progesterone withdrawal. Interferon anti-viral activity was detectable in uterine flushings from day 16 to day 22, and increased with duration of gestation (P < 0.01) and developmental stage (P < 0.01). When interferon-tau was administered daily between day 14 and day 20 to non-pregnant hinds to mimic natural blastocyst production, luteolysis was delayed by a dose of 0.2 mg day(-1) (27.3 +/- 1.3 days after synchronization, n = 4 versus 21 +/- 0 days in control hinds, n = 3; P < 0.05). Interferon-tau was administered to hinds after asynchronous embryo transfer to determine whether it protects the conceptus against early pregnancy loss. Embryos (n = 24) collected on day 6 from naturally mated, superovulated donors (n = 15) were transferred into synchronized recipients on day 10 or day 11. Interferon-tau treatment (0.2 mg daily from day 14 to 20) increased calving rate from 0 to 64% in all recipients (0/11 versus 7/11, P < 0.005), and from 0 to 67% in day 10 recipients (0/8 versus 6/9, P < 0.01). The increased success rate of asynchronous embryo transfer after interferon-tau treatment in cervids may be of benefit where mismatched embryo-maternal signalling leads to failure in the establishment of pregnancy.

scholarly journals A Functional Protein Kinase C Is Required for Induction of 2-5A Synthetase by Recombinant Interferon-αA in Daudi Cells

1989 ◽  
Vol 264 (24) ◽  
pp. 14305-14311 ◽  
Author(s):  
C R Faltynek ◽  
G L Princler ◽  
G L Gusella ◽  
L Varesio ◽  
D Radzioch
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Functional Protein ◽  
Recombinant Interferon ◽  
Kinase C ◽  
Daudi Cells

Recombinant interferon alpha-2a for treatment of herpes zoster in immunosuppressed patients with cancer

1988 ◽  
Vol 85 (2) ◽  
pp. 147-151 ◽  
Author(s):  
Drew J. Winston ◽  
Lawrence J. Eron ◽  
Monto Ho ◽  
George Pazin ◽  
Harold Kessler ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Interferon Alpha ◽  
Recombinant Interferon ◽  
Patients With Cancer ◽  
Immunosuppressed Patients ◽  
Recombinant Interferon Alpha

Allergy of delayed type to recombinant interferon α 2c

1989 ◽  
Vol 20 (2) ◽  
pp. 149-150 ◽  
Author(s):  
Ulf Detmar ◽  
Monika Agathos ◽  
Christoph Nerl
Keyword(s):  
Interferon Α ◽  
Recombinant Interferon

A randomized controlled trial of recombinant interferon-beta 1a in Guillain-Barre syndrome

Neurology ◽  
2003 ◽  
Vol 61 (9) ◽  
pp. 1282-1284 ◽  
Author(s):  
J. Pritchard ◽  
I. A. Gray ◽  
Z. R. Idrissova ◽  
B. R.F. Lecky ◽  
I. J. Sutton ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Interferon Beta ◽  
Controlled Trial ◽  
Guillain Barre Syndrome ◽  
Recombinant Interferon ◽  
Randomized Controlled ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Kinetic Evidence on the Mechanism of the Acid Denaturation of Horse CO Hemoglobin1

1951 ◽  
Vol 73 (12) ◽  
pp. 5568-5572 ◽  
Author(s):  
Ethel M. Zaiser ◽  
Jacinto Steinhardt
Keyword(s):  
Acid Denaturation
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