A comparison between β‐tricalcium phosphate verse chitosan poly‐caprolactone ‐based 3D melt extruded composite scaffolds

Biopolymers ◽  
2021 ◽  
Author(s):  
Minami Yoshida ◽  
Paul R. Turner ◽  
Christopher John McAdam ◽  
Mohammed Azam Ali ◽  
Jaydee D. Cabral
Keyword(s):  
Tricalcium Phosphate ◽  
Composite Scaffolds ◽  
Poly Caprolactone

Characteristics and Osteoconductivity of Bone Composite Scaffolds Made of Thai Silk Fibroin, Gelatin and Inorganic Compounds: A Comparative Study of β-Tricalcium Phosphate and Hydroxyapatite

2015 ◽  
Vol 354 (1) ◽  
pp. 258-264 ◽  
Author(s):  
Chotika Dararutana ◽  
Juthamas Ratanavaraporn ◽  
Sittisak Honsawek ◽  
Sorada Kanokpanont ◽  
Siriporn Damrongsakkul
Keyword(s):  
Comparative Study ◽  
Silk Fibroin ◽  
Tricalcium Phosphate ◽  
Inorganic Compounds ◽  
Composite Scaffolds

scholarly journals Treatment of osteomyelitis defects by a vancomycin-loaded gelatin/β-tricalcium phosphate composite scaffold

2018 ◽  
Vol 7 (1) ◽  
pp. 46-57 ◽  
Author(s):  
J. Zhou ◽  
X. G. Zhou ◽  
J. W. Wang ◽  
H. Zhou ◽  
J. Dong
Keyword(s):  
Controlled Release ◽  
Tricalcium Phosphate ◽  
Chronic Osteomyelitis ◽  
Composite Scaffold ◽  
Bone Defects ◽  
Therapeutic Drug ◽  
Porous Scaffolds ◽  
Composite Scaffolds ◽  
Extended Duration ◽  
Thorough Debridement

Objective In the present study, we aimed to assess whether gelatin/β-tricalcium phosphate (β-TCP) composite porous scaffolds could be used as a local controlled release system for vancomycin. We also investigated the efficiency of the scaffolds in eliminating infections and repairing osteomyelitis defects in rabbits. Methods The gelatin scaffolds containing differing amounts of of β-TCP (0%, 10%, 30% and 50%) were prepared for controlled release of vancomycin and were labelled G-TCP0, G-TCP1, G-TCP3 and G-TCP5, respectively. The Kirby-Bauer method was used to examine the release profile. Chronic osteomyelitis models of rabbits were established. After thorough debridement, the osteomyelitis defects were implanted with the scaffolds. Radiographs and histological examinations were carried out to investigate the efficiency of eliminating infections and repairing bone defects. Results The prepared gelatin/β-TCP scaffolds exhibited a homogeneously interconnected 3D porous structure. The G-TCP0 scaffold exhibited the longest duration of vancomycin release with a release duration of eight weeks. With the increase of β-TCP contents, the release duration of the β-TCP-containing composite scaffolds was decreased. The complete release of vancomycin from the G-TCP5 scaffold was achieved within three weeks. In the treatment of osteomyelitis defects in rabbits, the G-TCP3 scaffold showed the most efficacious performance in eliminating infections and repairing bone defects. Conclusions The composite scaffolds could achieve local therapeutic drug levels over an extended duration. The G-TCP3 scaffold possessed the optimal porosity, interconnection and controlled release performance. Therefore, this scaffold could potentially be used in the treatment of chronic osteomyelitis defects. Cite this article: J. Zhou, X. G. Zhou, J. W. Wang, H. Zhou, J. Dong. Treatment of osteomyelitis defects by a vancomycin-loaded gelatin/β-tricalcium phosphate composite scaffold. Bone Joint Res 2018;7:46–57. DOI: 10.1302/2046-3758.71.BJR-2017-0129.R2.

Preparation and Characterization of a Novel γ-PGA/β-Tricalcium Phosphate Composite for Tissue Engineering

2014 ◽  
Vol 900 ◽  
pp. 306-311 ◽  
Author(s):  
Xiu Lin Shu ◽  
Qing Shan Shi ◽  
Xiao Bao Xie ◽  
Xiao Mo Huang ◽  
Yi Ben Chen
Keyword(s):  
Tissue Engineering ◽  
Cell Growth ◽  
Porous Structure ◽  
Water Absorption ◽  
Tricalcium Phosphate ◽  
Absorption Rate ◽  
Swelling Ratio ◽  
Composite Scaffolds

In order to improvedβ-TCP biocompatibility and cell growth, was chosen to modify β-TCP matrices to produce a γ-PGA/β-TCP composite biomaterial. Then, the morphology, water uptake and retention abilities,in vitrodegradation property in the simulated medium, cytotoxicity of this novel γ-PGA/β-TCP composite is investigated. SEM shows that the γ-PGA/β-TCP composite has a porous structure. By increasing the percentage ofγ-PGA from 0% to 50%, the swelling ratio of the composite s was enhanced from 9.0%to 297%. These data suggested that the surface hydrophilicity, water absorption rate, and swelling ratio were improved by adding γ-PGA to the composite. In the cytocompatibility test, the density of MC3T3-E1 preosteoblasts cells on the PTCP1:1 leachates was almost 110% higher than that on the controls on day 3. Therefore, the γ-PGA/β-TCP composite scaffolds, due to their better hydrophilicity, cytocompatibility, and porous structure, are very promising biomaterials for tissure engineering applications.

scholarly journals Poly(Dopamine) Coating on 3D-Printed Poly-Lactic-Co-Glycolic Acid/β-Tricalcium Phosphate Scaffolds for Bone Tissue Engineering

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4397 ◽  
Author(s):  
Zhimin Xu ◽  
Ningning Wang ◽  
Peng Liu ◽  
Yidan Sun ◽  
Yumeng Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tricalcium Phosphate ◽  
Glycolic Acid ◽  
Malignant Tumors ◽  
Limiting Factors ◽  
Micro Computed Tomography ◽  
Composite Scaffolds ◽  
Biological Tests

Bone defects caused by osteoporosis, bone malignant tumors, and trauma are very common, but there are many limiting factors in the clinical treatment of them. Bone tissue engineering is the most promising treatment and is considered to be the main strategy for bone defect repair. We prepared polydopamine-coated poly-(lactic-co-glycolic acid)/β-tricalcium phosphate composite scaffolds via 3D printing, and a series of characterization and biocompatibility tests were carried out. The results show that the mechanical properties and pore-related parameters of the composite scaffolds are not affected by the coatings, and the hydrophilicities of the surface are obviously improved. Scanning electron microscopy and micro-computed tomography display the nanoscale microporous structure of the bio-materials. Biological tests demonstrate that this modified surface can promote cell adhesion and proliferation and improve osteogenesis through the increase of polydopamine (PDA) concentrations. Mouse cranial defect experiments are conducted to further verify the conclusion that scaffolds with a higher content of PDA coatings have a better effect on the formation of new bones. In the study, the objective of repairing critical-sized defects is achieved by simply adding PDA as coatings to obtain positive results, which can suggest that this modification method with PDA has great potential.

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