Molecular design and genetic optimization of antimicrobial peptides containing unnatural amino acids against antibiotic-resistant bacterial infections

Biopolymers ◽  
2016 ◽  
Vol 106 (5) ◽  
pp. 746-756 ◽  
Author(s):  
Yongkang He ◽  
Xiaofeng He
Keyword(s):  
Amino Acids ◽  
Antimicrobial Peptides ◽  
Unnatural Amino Acids ◽  
Bacterial Infections ◽  
Molecular Design ◽  
Genetic Optimization ◽  
Antibiotic Resistant

Advances on chemically modified antimicrobial peptides for generating peptide antibiotics

2021 ◽  
Author(s):  
Samilla Rezende ◽  
karen k.n. oshiro ◽  
Nelson Junior ◽  
Octavio L. Franco ◽  
Marlon Henrique Cardoso
Keyword(s):  
Clinical Trials ◽  
Antimicrobial Peptides ◽  
Bacterial Infections ◽  
Peptide Antibiotics ◽  
Antibiotic Resistant ◽  
Chemically Modified

Antimicrobial peptides (AMPs) are pinpointed as promising molecules against antibiotic-resistant bacterial infections. Nevertheless, there is a discrepancy between the AMP sequences generated and the tangible outcomes in clinical trials. AMPs’...

scholarly journals The Design of Bacteria Strain Selective Antimicrobial Peptides Based on the Incorporation of Unnatural Amino Acids

10.5772/33084 ◽  
2012 ◽  
Author(s):  
Amanda L. ◽  
David Klapper ◽  
Antoine H. ◽  
Jayendra B. ◽  
Richard Borschel ◽  
...  
Keyword(s):  
Amino Acids ◽  
Antimicrobial Peptides ◽  
Unnatural Amino Acids

Molecular Design and Synthesis of Artificial Ion Channels Based on Cyclic Peptides Containing Unnatural Amino Acids

2001 ◽  
Vol 66 (9) ◽  
pp. 2978-2989 ◽  
Author(s):  
Hitoshi Ishida ◽  
Zhi Qi ◽  
Masahiro Sokabe ◽  
Kiyoshi Donowaki ◽  
Yoshihisa Inoue
Keyword(s):  
Amino Acids ◽  
Ion Channels ◽  
Unnatural Amino Acids ◽  
Cyclic Peptides ◽  
Molecular Design ◽  
Design And Synthesis

scholarly journals Natural and Synthetic Halogenated Amino Acids—Structural and Bioactive Features in Antimicrobial Peptides and Peptidomimetics

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7401
Author(s):  
Mario Mardirossian ◽  
Marina Rubini ◽  
Mauro F. A. Adamo ◽  
Marco Scocchi ◽  
Michele Saviano ◽  
...  
Keyword(s):  
Amino Acids ◽  
Antimicrobial Peptides ◽  
Mode Of Action ◽  
Biological Effects ◽  
3D Structure ◽  
Surface Characteristics ◽  
Antimicrobial Drugs ◽  
Antibiotic Resistant ◽  
Physico Chemical ◽  
Proteins And Peptides

The 3D structure and surface characteristics of proteins and peptides are crucial for interactions with receptors or ligands and can be modified to some extent to modulate their biological roles and pharmacological activities. The introduction of halogen atoms on the side-chains of amino acids is a powerful tool for effecting this type of tuning, influencing both the physico-chemical and structural properties of the modified polypeptides, helping to first dissect and then rationally modify features that affect their mode of action. This review provides examples of the influence of different types of halogenation in amino acids that replace native residues in proteins and peptides. Examples of synthetic strategies for obtaining halogenated amino acids are also provided, focusing on some representative compounds and their biological effects. The role of halogenation in native and designed antimicrobial peptides (AMPs) and their mimetics is then discussed. These are in the spotlight for the development of new antimicrobial drugs to counter the rise of antibiotic-resistant pathogens. AMPs represent an interesting model to study the role that natural halogenation has on their mode of action and also to understand how artificially halogenated residues can be used to rationally modify and optimize AMPs for pharmaceutical purposes.

Determining the effect of the incorporation of unnatural amino acids into antimicrobial peptides on the interactions with zwitterionic and anionic membrane model systems

2011 ◽  
Vol 164 (8) ◽  
pp. 740-758 ◽  
Author(s):  
Amanda L. Russell ◽  
Anthony M. Kennedy ◽  
Anne M. Spuches ◽  
William S. Gibson ◽  
Divakaramenon Venugopal ◽  
...  
Keyword(s):  
Amino Acids ◽  
Antimicrobial Peptides ◽  
Unnatural Amino Acids ◽  
Model Systems ◽  
Membrane Model

scholarly journals Antimicrobial peptides: mechanism of action, activity and clinical potential

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Qi-Yu Zhang ◽  
Zhi-Bin Yan ◽  
Yue-Ming Meng ◽  
Xiang-Yu Hong ◽  
Gang Shao ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Bacterial Infections ◽  
Biological Activities ◽  
Structural Characteristics ◽  
Rapid Evolution ◽  
High Specificity ◽  
Mechanisms Of Action ◽  
Resistant Bacteria ◽  
Antibiotic Resistant ◽  
Clinical Potential

AbstractThe management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance, antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin, structural characteristics, mechanisms of action, biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.

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