scholarly journals Conserved G-Quadruplex Motifs in Gene Promoter Region Reveals a Novel Therapeutic Approach to Target Multi-Drug Resistance Klebsiella pneumoniae

2020 ◽  
Vol 11 ◽  
Author(s):  
Uma Shankar ◽  
Neha Jain ◽  
Subodh Kumar Mishra ◽  
Tarun Kumar Sharma ◽  
Amit Kumar
Keyword(s):  
Drug Resistance ◽  
Klebsiella Pneumoniae ◽  
Therapeutic Approach ◽  
Promoter Region ◽  
Gene Promoter ◽  
Multi Drug Resistance ◽  
G Quadruplex ◽  
Gene Promoter Region ◽  
Novel Therapeutic

scholarly journals Investigation of the Complexes Formed between PARP1 Inhibitors and PARP1 G-Quadruplex at the Gene Promoter Region

2021 ◽  
Vol 22 (16) ◽  
pp. 8737
Author(s):  
Sabrina Dallavalle ◽  
Salvatore Princiotto ◽  
Luce M. Mattio ◽  
Roberto Artali ◽  
Loana Musso ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Promoter Region ◽  
Gene Promoter ◽  
Parp Inhibition ◽  
Potential Binding ◽  
G Quadruplex ◽  
Parp1 Inhibitors ◽  
Tumoral Cells ◽  
Gene Promoter Region

DNA repair inhibitors are one of the latest additions to cancer chemotherapy. In general, chemotherapy produces DNA damage but tumoral cells may become resistant if enzymes involved in DNA repair are overexpressed and are able to reverse DNA damage. One of the most successful drugs based on modulating DNA repair are the poly(ADP-ribose) polymerase 1 (PARP1) inhibitors. Several PARP1 inhibitors have been recently developed and approved for clinical treatments. We envisaged that PARP inhibition could be potentiated by simultaneously modulating the expression of PARP 1 and the enzyme activity, by a two-pronged strategy. A noncanonical G-quadruplex-forming sequence within the PARP1 promoter has been recently identified. In this study, we explored the potential binding of clinically approved PARP1 inhibitors to the G-quadruplex structure found at the gene promoter region. The results obtained by NMR, CD, and fluorescence titration confirmed by molecular modeling demonstrated that two out the four PARP1 inhibitors studied are capable of forming defined complexes with the PARP1 G-quadruplex. These results open the possibility of exploring the development of better G-quadruplex binders that, in turn, may also inhibit the enzyme.

scholarly journals Characterization of the human pleiotrophin gene. Promoter region and chromosomal localization.

1992 ◽  
Vol 267 (36) ◽  
pp. 26011-26016 ◽  
Author(s):  
Y.S. Li ◽  
R.M. Hoffman ◽  
M.M. Le Beau ◽  
R Espinosa ◽  
N.A. Jenkins ◽  
...  
Keyword(s):  
Promoter Region ◽  
Chromosomal Localization ◽  
Gene Promoter ◽  
Gene Promoter Region

scholarly journals Polymorphism in SNAP29 gene promoter region associated with schizophrenia

2001 ◽  
Vol 6 (2) ◽  
pp. 193-201 ◽  
Author(s):  
T Saito ◽  
F Guan ◽  
D F Papolos ◽  
N Rajouria ◽  
C S J Fann ◽  
...  
Keyword(s):  
Promoter Region ◽  
Gene Promoter ◽  
Gene Promoter Region

scholarly journals Polymorphisms of the ELANE Gene Promoter Region in End-Stage Chronic Kidney Disease Patients

Genes ◽  
2016 ◽  
Vol 7 (5) ◽  
pp. 17
Author(s):  
Rafael Fernandes ◽  
Bruno Freitas ◽  
Vasco Miranda ◽  
Elísio Costa ◽  
Alice Santos-Silva ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Promoter Region ◽  
Gene Promoter ◽  
End Stage ◽  
Gene Promoter Region
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