scholarly journals Fluorescence of unmodified oligonucleotides: A tool to probe G-quadruplex DNA structure

Biopolymers ◽  
2009 ◽  
Vol 91 (10) ◽  
pp. 841-850 ◽  
Author(s):  
Miguel Angel Mendez ◽  
Veronika A. Szalai
Keyword(s):  
Dna Structure ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals Subtle structural alterations in G-quadruplex DNA regulate site specificity of fluorescence light-up probes

2020 ◽  
Vol 48 (3) ◽  
pp. 1108-1119 ◽  
Author(s):  
Rajendra Kumar ◽  
Karam Chand ◽  
Sudipta Bhowmik ◽  
Rabindra Nath Das ◽  
Snehasish Bhattacharjee ◽  
...  
Keyword(s):  
Rational Design ◽  
Dna Structure ◽  
Biological Processes ◽  
Chemical Research ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
Future Studies ◽  
G4 Dna ◽  
G Quadruplex ◽  
Fluorescence Light

Abstract G-quadruplex (G4) DNA structures are linked to key biological processes and human diseases. Small molecules that target specific G4 DNA structures and signal their presence would therefore be of great value as chemical research tools with potential to further advance towards diagnostic and therapeutic developments. However, the development of these types of specific compounds remain as a great challenge. In here, we have developed a compound with ability to specifically signal a certain c-MYC G4 DNA structure through a fluorescence light-up mechanism. Despite the compound's two binding sites on the G4 DNA structure, only one of them result in the fluorescence light-up effect. This G-tetrad selectivity proved to originate from a difference in flexibility that affected the binding affinity and tilt the compound out of the planar conformation required for the fluorescence light-up mechanism. The intertwined relation between the presented factors is likely the reason for the lack of examples using rational design to develop compounds with turn-on emission that specifically target certain G4 DNA structures. However, this study shows that it is indeed possible to develop such compounds and present insights into the molecular details of specific G4 DNA recognition and signaling to advance future studies of G4 biology.

scholarly journals A G-quadruplex DNA structure resolvase, RHAU, is essential for spermatogonia differentiation

2015 ◽  
Vol 6 (1) ◽  
pp. e1610-e1610 ◽  
Author(s):  
X Gao ◽  
W Ma ◽  
J Nie ◽  
C Zhang ◽  
J Zhang ◽  
...  
Keyword(s):  
Dna Structure ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals Metadynamics Study of the Free Energy Surface of a G-Quadruplex DNA Structure

2010 ◽  
Vol 98 (3) ◽  
pp. 265a
Author(s):  
Juan-Antonio Mondragón-Sánchez ◽  
Edmundo Mendieta-Fernández ◽  
Ramon Garduño-Juárez ◽  
Gilberto Sánchez-González
Keyword(s):  
Free Energy ◽  
Energy Surface ◽  
Dna Structure ◽  
Free Energy Surface ◽  
Quadruplex Dna ◽  
G Quadruplex

Identification of novel interactors of human telomeric G-quadruplex DNA

2015 ◽  
Vol 51 (14) ◽  
pp. 2964-2967 ◽  
Author(s):  
Bruno Pagano ◽  
Luigi Margarucci ◽  
Pasquale Zizza ◽  
Jussara Amato ◽  
Nunzia Iaccarino ◽  
...  
Keyword(s):  
Binding Proteins ◽  
Dna Structure ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
In Cells

Starting from a chemoproteomic-driven approach, novel human telomeric G-quadruplex binding proteins were identified that directly bind the DNA structure in vitro and colocalize with such structures in cells.

Induction of G-quadruplex DNA structure by Zn(II) 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin

Biochimie ◽  
2011 ◽  
Vol 93 (8) ◽  
pp. 1297-1309 ◽  
Author(s):  
Amlan J. Bhattacharjee ◽  
Karan Ahluwalia ◽  
Scott Taylor ◽  
Ou Jin ◽  
John M. Nicoludis ◽  
...  
Keyword(s):  
Dna Structure ◽  
Quadruplex Dna ◽  
G Quadruplex

scholarly journals A Small Molecule That Disrupts G-Quadruplex DNA Structure and Enhances Gene Expression

2009 ◽  
Vol 131 (35) ◽  
pp. 12628-12633 ◽  
Author(s):  
Zoë A. E. Waller ◽  
Sven A. Sewitz ◽  
Shang-Te Danny Hsu ◽  
Shankar Balasubramanian
Keyword(s):  
Gene Expression ◽  
Small Molecule ◽  
Dna Structure ◽  
Quadruplex Dna ◽  
G Quadruplex
Sign in / Sign up

Export Citation Format

Share Document