Pro-region engineering for improved yeast display and secretion of brain derived neurotrophic factor

Michael L. Burns; Thomas M. Malott; Kevin J. Metcalf; Arthya Puguh; Jonah R. Chan; Eric V. Shusta

doi:10.1002/biot.201500360

Pro-region engineering for improved yeast display and secretion of brain derived neurotrophic factor

Biotechnology Journal ◽

10.1002/biot.201500360 ◽

2015 ◽

Vol 11 (3) ◽

pp. 425-436 ◽

Cited By ~ 3

Author(s):

Michael L. Burns ◽

Thomas M. Malott ◽

Kevin J. Metcalf ◽

Arthya Puguh ◽

Jonah R. Chan ◽

...

Keyword(s):

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Yeast Display ◽

Pro Region

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Temporal changes in the expression of brain-derived neurotrophic factor mRNA in the ventromedial nucleus of the hypothalamus of the developing rat brain

Molecular Brain Research ◽

10.1016/s0006-8993(03)02773-2 ◽

2003 ◽

Author(s):

N Sugiyama

Keyword(s):

Rat Brain ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Temporal Changes ◽

Ventromedial Nucleus ◽

Developing Rat

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Effects of β-Adrenoreceptor Blockade During Chronic Exercise on Contextual Fear Conditioning and mRNA for Galanin and Brain-Derived Neurotrophic Factor.

Behavioral Neuroscience ◽

10.1037/0735-7044.118.6.1378 ◽

2004 ◽

Vol 118 (6) ◽

pp. 1378-1390 ◽

Cited By ~ 70

Author(s):

Jacqueline D. Van Hoomissen ◽

Philip V. Holmes ◽

Andrew S. Zellner ◽

Adeline Poudevigne ◽

Rod K. Dishman

Keyword(s):

Fear Conditioning ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Contextual Fear Conditioning ◽

Chronic Exercise ◽

Contextual Fear

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Brain Derived Neurotrophic Factor Gene Polymorphism Associated With Language Acquisition

PsycEXTRA Dataset ◽

10.1037/e657062007-001 ◽

2007 ◽

Author(s):

Scott H. Fraundorf ◽

Brad E. Sheese ◽

Lauren K. White ◽

Mary K. Rothbart ◽

Michael I. Posner

Keyword(s):

Language Acquisition ◽

Gene Polymorphism ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Factor Gene

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Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder

PsycEXTRA Dataset ◽

10.1037/e717702011-005 ◽

2009 ◽

Author(s):

L. Dell'osso ◽

C. Carmassi ◽

A. Del Debbio ◽

M. C. Dell'osso ◽

C. Bianchi ◽

...

Keyword(s):

Post Traumatic Stress Disorder ◽

Traumatic Stress ◽

Neurotrophic Factor ◽

Plasma Levels ◽

Stress Disorder ◽

Brain Derived Neurotrophic Factor ◽

Post Traumatic Stress ◽

Post Traumatic

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Induction by convulsant drugs of brain-derived neurotrophic factor in the rat brain: an involvement of voltage-dependent calcium channels

Neuroscience Research ◽

10.1016/s0168-0102(00)81678-8 ◽

2000 ◽

Vol 38 ◽

pp. S138

Author(s):

R Katoh-Semba

Keyword(s):

Calcium Channels ◽

Rat Brain ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Voltage Dependent ◽

Voltage Dependent Calcium Channels

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Von der Entzündung zur Degeneration: die Bedeutung des Neurotrophins brain derived neurotrophic factor bei autoimmuner Entmarkung im zentralen Nervensystem

Aktuelle Neurologie ◽

10.1055/s-0028-1086853 ◽

2008 ◽

Vol 35 (S 01) ◽

Author(s):

F Lühder ◽

D Lee ◽

S Cetin ◽

S Wiese ◽

N Kruse ◽

...

Keyword(s):

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor

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Brain derived neurotrophic factor (BDNF) reguliert Apoptose in primärer enterischer Glia über einen autokrinen Mechanismus

Zeitschrift für Gastroenterologie ◽

10.1055/s-0028-1089731 ◽

2008 ◽

Vol 46 (09) ◽

Author(s):

M Steinkamp ◽

N Degenkolb ◽

H Gundel ◽

S Kunsch ◽

G Adler ◽

...

Keyword(s):

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor

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The Brain-Derived Neurotrophic Factor (BDNF) Val66Met polymorphism modulates the effects of serious life events on impulsive aggression in patients with Borderline Personality Disorder

Pharmacopsychiatry ◽

10.1055/s-0029-1240244 ◽

2009 ◽

Vol 42 (05) ◽

Author(s):

S Wagner ◽

Ö Baskaya ◽

K Lieb ◽

N Dahmen ◽

A Tadic

Keyword(s):

Borderline Personality Disorder ◽

Personality Disorder ◽

Life Events ◽

Neurotrophic Factor ◽

Brain Derived Neurotrophic Factor ◽

Borderline Personality ◽

Val66met Polymorphism ◽

Impulsive Aggression ◽

Bdnf Val66met Polymorphism ◽

The Brain

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Impact of a haplotype (Val66Met) in the brain derived neurotrophic factor (BDNF) gene on serotonergic neurotransmission as reflected by the loudness dependence of auditory evoked potentials

Klinische Neurophysiologie ◽

10.1055/s-0030-1250899 ◽

2010 ◽

Vol 41 (01) ◽

Author(s):

C Norra ◽

C Schumacher ◽

I Giegling ◽

H Assion ◽

P Mavrogiorgou ◽

...

Keyword(s):

Evoked Potentials ◽

Neurotrophic Factor ◽

Auditory Evoked Potentials ◽

Brain Derived Neurotrophic Factor ◽

Bdnf Gene ◽

Serotonergic Neurotransmission ◽

Loudness Dependence ◽

The Brain

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Die Bedeutung der genetischen Bildgebung für psychiatrische Störungen

Die Psychiatrie ◽

10.1055/s-0038-1669666 ◽

2009 ◽

Vol 6 (04) ◽

pp. 191-198

Author(s):

C. Konrad ◽

A. Krug ◽

T. Kircher

Keyword(s):

Neurotrophic Factor ◽

Binding Protein ◽

Brain Derived Neurotrophic Factor ◽

Methyl Transferase ◽

Psychiatrische Forschung ◽

Psychiatrische Störungen

ZusammenfassungPsychiatrische Störungen sind zu einem großen Teil erblich beeinflusst. Ein verbessertes Verständnis der molekulargenetischen Grundlagen dieser Erblichkeit ist für Klassifikation, Erforschung der Pathogenese und Therapie bedeutsam. Die Gewinnung neuer Erkenntnisse hängt dabei entscheidend von der Auswahl des untersuchten Phänotyps ab. Die Varianz beobachtbarer Phänotypen wird durch eine Vielzahl unterschiedlicher Einflussfaktoren zu einem geringeren Anteil genetisch beeinflusst als die Varianz von Endophänotypen, die mit Hilfe der strukturellen und funktionellen Bildgebung beobachtet werden können. Wichtige Erkenntnisse aus der genetischen Depressions- und Schizophrenieforschung werden zu diesem Thema zusammengefasst. Der Einfluss von Kandidatengenen auf Erleben und Verhalten sowie auf strukturelle und funktionelle Bildgebungscharakteristika wird dargestellt, u.a. bezüglich des Serotonintransporter-Gens (5HTTLPR), Brain Derived Neurotrophic Factor (BDNF), Catechyl-O-Methyl-Transferase (COMT), Neuregulin1 (NRG1), Dysbindin (dystrobrevin binding protein 1, DTNBP1) und Zinkfinger Protein 804A (ZNF804A). Perspektiven für die psychiatrische Forschung werden diskutiert.

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