High‐throughput profiling reveals perturbation of endoplasmic reticulum stress‐related genes in atherosclerosis induced by high‐cholesterol diet and the protective role of vitamin E

BioFactors ◽  
2020 ◽  
Vol 46 (4) ◽  
pp. 653-664
Author(s):  
Perinur Bozaykut ◽  
Ruchan Ekren ◽  
Osman Ugur Sezerman ◽  
Vadim N. Gladyshev ◽  
Nesrin Kartal Ozer
Keyword(s):  
Endoplasmic Reticulum ◽  
Vitamin E ◽  
Endoplasmic Reticulum Stress ◽  
High Throughput ◽  
Protective Role ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Stress Related Genes

scholarly journals Sericin ameliorated dysmorphic mitochondria in high-cholesterol diet/streptozotocin rat by antioxidative property

2016 ◽  
Vol 242 (4) ◽  
pp. 411-421 ◽  
Author(s):  
Sumate Ampawong ◽  
Duangnate Isarangkul ◽  
Pornanong Aramwit
Keyword(s):  
Endoplasmic Reticulum ◽  
Exocrine Pancreas ◽  
Protective Role ◽  
Blood Cholesterol ◽  
High Cholesterol Diet ◽  
Zymogen Granule ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Electron Microscopic ◽  
Antioxidative Property

Sericin has been implicated in lower cholesterolemic effect due to its properties with several mechanisms. Mitochondria are one of the most important targets to be affected in high blood cholesterol and glucose conditions. The protective role of sericin on mitochondria remains doubtful. To examine this role, electron microscopic, histopathologic, immunohistochemical, and biochemical studies were performed in a high-cholesterol diet/streptozotocin rat model. The results demonstrated that sericin reduced blood cholesterol without hypoglycemic effect. Sericin alleviated dysmorphic mitochondria in heart and liver but not in kidney and also decreased peculiar endoplasmic reticulum in the exocrine pancreas. In addition, sericin decreased hepatic steatosis and preserved zymogen granule referable to the decline of reactive oxygen species production in hepatic mitochondrial extraction and down-regulation of malondialdehyde expression in the liver and exocrine pancreas however irrelevant to lipase activity. This study suggests that sericin has antioxidative property to reduce blood cholesterol by means of diminishing fat deposit in hepatocyte and improves mitochondria and endoplasmic reticulum integrities. [Box: see text]

High cholesterol diet promotes dysfunction of arginase and cholinergic enzymatic system in rats: ameliorative role of caffeic and chlorogenic acids

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Odunayo Michael Agunloye ◽  
Ganiyu Oboh
Keyword(s):  
Chlorogenic Acid ◽  
Antioxidant Status ◽  
Inverse Relationship ◽  
Protective Role ◽  
High Cholesterol Diet ◽  
Enzymatic System ◽  
Cholesterol Diet ◽  
Chlorogenic Acids ◽  
High Cholesterol

AbstractBackgroundDietary phenolic compounds intake have been reported to have an inverse relationship to the prevalence of hypercholesterolemia. The objective of this study is to determine the effect of caffeic acid (CFA) and chlorogenic acid (CGA) on rats fed with high cholesterol diet (HCD).MethodsExperimental animals were fed with high cholesterol diet (HCD) for a period of 21 days while simvastatin (0.2 mg/kg BWT), CFA and CGA (10 and 15 mg/kg BWT) were administered daily.ResultsActivity of acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and arginase were significantly (P<0.05) higher in the rats fed with HCD alone. Also, level of malondiadehyde equivalent compounds (MDA) was significantly (P<0.05) elevated in hypercholesterolemic rats. Nevertheless, treatment with simvastatin, CFA and CGA normalized altered AChE, BChE and arginase activities as well as improved antioxidant status in hypercholesterolemic rats.ConclusionCFA and CGA could offer protective role in hypercholeseterolemic rats via their antioxidant potentials as well as restoring altered activity of acetylcholinesterase, butrylcholinesterase and arginase. Based on our findings chlorogenic acid exhibits better attribute.

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