Synthesis, anticancer activity, and β‐lactoglobulin binding interactions of multitargeted kinase inhibitor sorafenib tosylate (SORt) using spectroscopic and molecular modelling approaches

Luminescence ◽  
2020 ◽  
Author(s):  
Hamid Tanzadehpanah ◽  
Asrin Bahmani ◽  
Neda Hosseinpour Moghadam ◽  
Hamid Gholami ◽  
Hanie Mahaki ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Molecular Modelling ◽  
Kinase Inhibitor ◽  
Binding Interactions ◽  
Β Lactoglobulin ◽  
Modelling Approaches

Thermodynamics of Binding Interactions between Bovine β-Lactoglobulin A and the Antihypertensive Peptide β-Lg f142-148

2006 ◽  
Vol 7 (2) ◽  
pp. 419-426 ◽  
Author(s):  
Samira Roufik ◽  
Sylvie F. Gauthier ◽  
Xiaojing Leng ◽  
Sylvie L. Turgeon
Keyword(s):  
Binding Interactions ◽  
Β Lactoglobulin

scholarly journals Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma

Blood ◽  
2017 ◽  
Vol 129 (13) ◽  
pp. 1768-1778 ◽  
Author(s):  
Sophia Gayle ◽  
Sean Landrette ◽  
Neil Beeharry ◽  
Chris Conrad ◽  
Marylens Hernandez ◽  
...  
Keyword(s):  
B Cell ◽  
Anticancer Activity ◽  
Mechanism Of Action ◽  
Kinase Inhibitor ◽  
Lysosomal Function ◽  
Non Hodgkin Lymphoma ◽  
Key Points ◽  
Unique Mechanism

Key Points Apilimod has broad anticancer activity in vitro and in vivo across all subtypes of B-NHL. Apilimod induces B-NHL cytotoxicity through a unique mechanism of action that involves the disruption of lysosomal function.

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