Spectrofluorimetric determination of certain adrenergic agonist drugs in their pure forms and pharmaceutical formulations: Content uniformity test application

Luminescence ◽  
2016 ◽  
Vol 32 (5) ◽  
pp. 706-712
Author(s):  
Khalid M. Badr El-Din ◽  
Tamer Z. Attia
Keyword(s):  
Pharmaceutical Formulations ◽  
Content Uniformity ◽  
Adrenergic Agonist ◽  
Test Application ◽  
Uniformity Test ◽  
Spectrofluorimetric Determination

Application of a quinone-based fluorophore for spectrofluorimetric determination of albendazole in pure form and pharmaceutical formulations

2016 ◽  
Vol 8 (25) ◽  
pp. 5136-5141 ◽  
Author(s):  
Khalid A. M. Attia ◽  
Ahmad A. Mohamad ◽  
Mohamed S. Emara
Keyword(s):  
Charge Transfer ◽  
Complex Formation ◽  
Pharmaceutical Formulations ◽  
Pure Form ◽  
Spectrofluorimetric Method ◽  
Spectrofluorimetric Determination ◽  
Ct Complex

A spectrofluorimetric method was developed for the determination of albendazole (ALB) through charge transfer (CT) complex formation with 7,7,8,8-tetracyanoquinodimethane (TCNQ).

scholarly journals SPECTROFLUORIMETRIC DETERMINATION OF EOSIN CHEMILUMINESCENCE SYSTEM FOR THE ANALYSIS OF DABIGATRAN IN PHARMACEUTICAL FORMULATIONS

2019 ◽  
pp. 104-108
Author(s):  
DHANAPAL Y ◽  
SRUDHIVINOD V ◽  
MOHAMAD WASEEM A
Keyword(s):  
Method Development ◽  
Pharmaceutical Formulations ◽  
Calibration Graph ◽  
Eosin Y ◽  
Linear Calibration ◽  
Reaction Conditions ◽  
Quenching Effect ◽  
Spectrofluorimetric Determination ◽  
Optimum Reaction

Objectives: The objectives of this study were to develop a rapid, simple, and economical spectrofluorometric method for quantification of dabigatran from marketed formulation and its principle involved based on the protonated process of a binary mixture complex formation with eosin Y. Methods: A simple and precise spectrofluorometric technique was applied for the method development. It depends on measuring the quenching effect of the drug on the native fluorescence of eosin at excitation under the optimum reaction conditions. Results: The reaction linear calibration graph constructed between the fluorescence quenching valves flouresence intensity (ΔF) and the concentration ranges of 5–50 μg/ml. Spectrofluorometric analytical performance was validated by accuracy, precision, and specificity, and the results were satisfactory. Conclusion: This method was to develop a fast, simple, and economically applied successfully for the assay, and qualification of dabigatran tablet contains drug, also with different coformulated pharmaceutical formulations.

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