scholarly journals Totally tubular: the mystery behind function and origin of the brain ventricular system

BioEssays ◽  
2009 ◽  
Vol 31 (4) ◽  
pp. 446-458 ◽  
Author(s):  
Laura Anne Lowery ◽  
Hazel Sive
Keyword(s):  
Ventricular System ◽  
Brain Ventricular System ◽  
The Brain

Impermeability of the Blood—Cerebrospinal Fluid Barrier for Angiotensin II in Rats

1976 ◽  
Vol 51 (s3) ◽  
pp. 399s-402s ◽  
Author(s):  
P. Schelling ◽  
J. S. Hutchinson ◽  
U. Ganten ◽  
G. Sponer ◽  
D. Ganten
Keyword(s):  
Cerebrospinal Fluid ◽  
Angiotensin Ii ◽  
Intravenous Infusion ◽  
Ventricular System ◽  
Cisterna Magna ◽  
Biochemical Methods ◽  
Intravenous Infusions ◽  
Artificial Cerebrospinal Fluid ◽  
Brain Ventricular System ◽  
The Brain

1. Anaesthetized, nephrectomized rats were infused intravenously with unlabelled angiotensin II (AII) or with [3H]angiotensin II (3H-labelled AII). The brain ventricular system was perfused with artificial cerebrospinal fluid. The perfusate was collected from the cisterna magna and analysed for AII by radioimmunological and biochemical methods. 2. No increase of immunoreactive AII in cerebrospinal fluid could be shown during intravenous infusion of AII. 3. During intravenous infusions of 3H-labelled AII at pressor doses small amounts of radioactivity were found in cerebrospinal fluid perfusate. 4. The radioactivity of cerebrospinal fluid outflow could not be related to AII.

A Region-Based Ontology of the Brain Ventricular System and Its Relation to Schizophrenia

2012 ◽  
pp. 255-272
Author(s):  
Paulo Santos ◽  
Rodolpho Freire ◽  
Danilo N. dos Santos ◽  
Carlos Thomaz ◽  
Paulo Sallet ◽  
...  
Keyword(s):  
Data Analysis ◽  
Statistical Data ◽  
Ventricular System ◽  
Statistical Data Analysis ◽  
Initial Region ◽  
Schizophrenic Patients ◽  
Formal Basis ◽  
Brain Ventricular System ◽  
The Brain

This chapter describes an initial region-based formalisation of some concepts about neuroanatomy into ontological and epistemic terms, as part of a major effort into the formalisation of the knowledge contained in neuroimages of patients with schizophrenia. The long-term goal is to build an ontology that is a formal basis for the expectations generated from statistical data analysis. To this end, the chapter presents an example of applying this ontology to interpret the results of image-based analysis of neuroimages from schizophrenic patients.

scholarly journals Camel regulates development of the brain ventricular system

2020 ◽  
Author(s):  
Shulan Yang ◽  
Alexander Emelyanov ◽  
May-Su You ◽  
Melvin Sin ◽  
Vladimir Korzh
Keyword(s):  
Cerebrospinal Fluid ◽  
Cell Adhesion ◽  
Molecular Mechanisms ◽  
Expression Patterns ◽  
Ventricular System ◽  
Fiber Formation ◽  
Loss Of Function ◽  
Roof Plate ◽  
Brain Ventricular System ◽  
The Brain

Abstract Development of the brain ventricular system of vertebrates and the molecular mechanisms involved are not fully understood. The developmental genes expressed in the elements of the brain ventricular system such as the ependyma and circumventricular organs act as molecular determinants of cell adhesion critical for the formation of brain ventricular system. They control brain development and function, including the flow of cerebrospinal fluid. Here, we describe the novel distantly related member of the zebrafish L1-CAM family of genes—camel. Whereas its maternal transcripts distributed uniformly, the zygotic transcripts demonstrate clearly defined expression patterns, in particular in the axial structures: floor plate, hypochord, and roof plate. camel expresses in several other cell lineages with access to the brain ventricular system, including the midbrain roof plate, subcommissural organ, organum vasculosum lamina terminalis, median eminence, paraventricular organ, flexural organ, and inter-rhombomeric boundaries. This expression pattern suggests a role of Camel in neural development. Several isoforms of Camel generated by differential splicing of exons encoding the sixth fibronectin type III domain enhance cell adhesion differentially. The antisense oligomer morpholino-mediated loss-of-function of Camel affects cell adhesion and causes hydrocephalus and scoliosis manifested via the tail curled down phenotype. The subcommissural organ’s derivative—the Reissner fiber—participates in the flow of cerebrospinal fluid. The Reissner fiber fails to form upon morpholino-mediated Camel loss-of-function. The Camel mRNA–mediated gain-of-function causes the Reissner fiber misdirection. This study revealed a link between Chl1a/Camel and Reissner fiber formation, and this supports the idea that CHL1 is one of the scoliosis factors.

Recombinant interferon-γ applied to the brain ventricular system protects rats against pseudorabies

1990 ◽  
Vol 28 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Virgil Schijns ◽  
Paul van Giersbergen ◽  
Huub Schellekens ◽  
Marian C. Horzinek
Keyword(s):  
Interferon Γ ◽  
Ventricular System ◽  
Recombinant Interferon ◽  
Brain Ventricular System ◽  
The Brain

Ciliary motility in brain ventricular system and trachea of hamster

1985 ◽  
Vol 330 (2) ◽  
pp. 291-297 ◽  
Author(s):  
Yehudah Roth ◽  
Yosef Kimhi ◽  
Habib Edery ◽  
Ephram Aharonson ◽  
Zvi Priel
Keyword(s):  
Ventricular System ◽  
Ciliary Motility ◽  
Brain Ventricular System

scholarly journals STUDIES IN THE PATHOGENESIS OF EXPERIMENTAL DYSENTERY INTOXICATION

1960 ◽  
Vol 111 (2) ◽  
pp. 145-153 ◽  
Author(s):  
Abraham Penner ◽  
Alice Ida Bernheim
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Intravenous Administration ◽  
Shiga Toxin ◽  
Third Ventricle ◽  
Dosage Level ◽  
Ventricular System ◽  
The Third ◽  
The Central Nervous System ◽  
The Brain

The introduction of Shiga toxin into the ventricular system of the brain with major location in the third ventricle resulted in a response similar to that following the administration of the toxin either intravenously or by cross-circulation. The intravenous administration at the dosage level employed would have elicited no response. These observations lend support to the hypothesis that Shiga toxin activates some mechanisms in the central nervous system which are capable of producing visceral lesions. These mechanisms are those which control the vasomotor components of homeostasis. This hypothesis permits an explanation of the proximo-distal and intramural features of the lesion.

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