The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings?

BioEssays ◽  
2004 ◽  
Vol 26 (2) ◽  
pp. 170-179 ◽  
Author(s):  
Scott M. Williams ◽  
Jonathan L. Haines ◽  
Jason H. Moore
Keyword(s):  
Animal Models ◽  
Complex Disease ◽  
Human Studies ◽  
Do So

Oxidative stress in phenylketonuria—evidence from human studies and animal models, and possible implications for redox signaling

2021 ◽  
Vol 36 (4) ◽  
pp. 523-543
Author(s):  
Vanessa Trindade Bortoluzzi ◽  
Carlos Severo Dutra Filho ◽  
Clovis Milton Duval Wannmacher
Keyword(s):  
Oxidative Stress ◽  
Animal Models ◽  
Redox Signaling ◽  
Human Studies

scholarly journals Etiologies of insomnia in Parkinson's disease – Lessons from human studies and animal models

2022 ◽  
pp. 113976
Author(s):  
Aviv D. Mizrahi-Kliger ◽  
Lucia K. Feldmann ◽  
Andrea A. Kuhn ◽  
Hagai Bergman
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Animal Models ◽  
Human Studies

Colon Health and Resistant Starch: Human Studies and Animal Models

2013 ◽  
pp. 267-278
Author(s):  
Suzanne Hendrich ◽  
Diane F. Birt ◽  
Li Li ◽  
Yinsheng Zhao
Keyword(s):  
Animal Models ◽  
Resistant Starch ◽  
Human Studies

Mesenchymal stem cells strategies in cancer immunotherapy

2021 ◽  
Author(s):  
Moataz Dowaidar
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Animal Models ◽  
Cancer Treatment ◽  
Cancer Immunotherapy ◽  
Human Studies ◽  
Research Focus ◽  
Cancer Treatments ◽  
The Future ◽  
New Research

Mesenchymal stem cells (MSCs) have been a new research focus for cancer treatment. Future cancer sufferers will considerably profit from their use in the future. Tumor-directed migratory and integration capacities of MSCs are exceptional, making them potential carriers for the delivery of anticancer medicines, notably cytokines. Their usage in the clinic has lasted around 10 years. The use of mesenchymal stem cells (MSCs) to create successful cancer treatments has been demonstrated in everything from animal models to human studies.

Neurotoxicity of General Anaesthetics

2019 ◽  
pp. 93-110
Author(s):  
Margaret K. Menzel Ellis ◽  
Ansgar Brambrink
Keyword(s):  
Animal Models ◽  
Prospective Studies ◽  
Cell Injury ◽  
Large Body ◽  
Neural Cell ◽  
Developing Brain ◽  
Human Studies ◽  
Childhood Exposure

This chapter covers the neurotoxicity of general anaesthetics. It discusses how a large body of preclinical evidence shows an association of anaesthetic exposure with neural cell injury and death in the developing brain. Several putative mechanisms have been demonstrated in vitro and in in vivo animal models. Furthermore, these exposures have been associated with impaired behavioural and cognitive development in young animals. Several retrospective human studies of neurocognitive and behavioural disorders following childhood exposure to anaesthesia suggest a similar association, and prospective studies in humans are currently ongoing. The implication of this information on anaesthetic practise remains to be seen.

Approaching Type 2 Diabetes Mellitus by Systems Biology

2009 ◽  
pp. 361-376
Author(s):  
Axel Rasche
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systems Biology ◽  
Animal Models ◽  
High Throughput ◽  
Complex Disease ◽  
Current Knowledge ◽  
High Throughput Experimentation

We acquired new computational and experimental prospects to seek insight and cure for millions of afflicted persons with an ancient malady. Type 2 diabetes mellitus (T2DM) is a complex disease with a network of interactions among several tissues and a multifactorial pathogenesis. Research conducted in human and multiple animal models has strongly focused on genetics so far. High-throughput experimentation technics like microarrays provide new tools at hand to amend current knowledge. By integrating those results the aim is to develop a systems biology model assisting the diagnosis and treatment. Beside experimentation techniques and platforms or rather general concepts for a new term in biology and medicine this chapter joins the conceptions with a rather actual medical challenge. It outlines current results and envisions a possible alley to the comprehension of T2DM.

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