scholarly journals Looking back and moving forward: Evaluating and advancing translation from animal models to human studies of early life stress and DNA methylation

2018 ◽  
Vol 61 (3) ◽  
pp. 323-340 ◽  
Author(s):  
Sarah Enos Watamura ◽  
Tania L. Roth
Keyword(s):  
Dna Methylation ◽  
Animal Models ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress ◽  
Human Studies ◽  
Looking Back

scholarly journals Early life stress induces age-dependent epigenetic changes in p11 gene expression in male mice

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mi Kyoung Seo ◽  
Jung Goo Lee ◽  
Sung Woo Park
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Histone Acetylation ◽  
Histone Methylation ◽  
Life Stress ◽  
Early Life ◽  
Age Groups ◽  
Early Life Stress ◽  
Epigenetic Modifications ◽  
Age Dependent

AbstractEarly life stress (ELS) causes long-lasting changes in gene expression through epigenetic mechanisms. However, little is known about the effects of ELS in adulthood, specifically across different age groups. In this study, the epigenetic modifications of p11 expression in adult mice subjected to ELS were investigated in different stages of adulthood. Pups experienced maternal separation (MS) for 3 h daily from postnatal day 1 to 21. At young and middle adulthood, behavioral test, hippocampal p11 expression levels, and levels of histone acetylation and methylation and DNA methylation at the hippocampal p11 promoter were measured. Middle-aged, but not young adult, MS mice exhibited increased immobility time in the forced swimming test. Concurrent with reduced hippocampal p11 levels, mice in both age groups showed a decrease in histone acetylation (AcH3) and permissive histone methylation (H3K4me3) at the p11 promoter, as well as an increase in repressive histone methylation (H3K27me3). Moreover, our results showed that the expression, AcH3 and H3Kme3 levels of p11 gene in response to MS were reduced with age. DNA methylation analysis of the p11 promoter revealed increased CpG methylation in middle-aged MS mice only. The results highlight the age-dependent deleterious effects of ELS on the epigenetic modifications of p11 transcription.

scholarly journals Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications

2015 ◽  
Vol 309 (12) ◽  
pp. G927-G941 ◽  
Author(s):  
Calvin S. Pohl ◽  
Julia E. Medland ◽  
Adam J. Moeser
Keyword(s):  
Animal Models ◽  
Life Stress ◽  
Early Life ◽  
Disease Susceptibility ◽  
Gastrointestinal Disease ◽  
Adult Life ◽  
Early Life Stress ◽  
Early Postnatal Development ◽  
Disease States ◽  
Fundamental Understanding

Early-life stress and adversity are major risk factors in the onset and severity of gastrointestinal (GI) disease in humans later in life. The mechanisms by which early-life stress leads to increased GI disease susceptibility in adult life remain poorly understood. Animal models of early-life stress have provided a foundation from which to gain a more fundamental understanding of this important GI disease paradigm. This review focuses on animal models of early-life stress-induced GI disease, with a specific emphasis on translational aspects of each model to specific human GI disease states. Early postnatal development of major GI systems and the consequences of stress on their development are discussed in detail. Relevant translational differences between species and models are highlighted.

scholarly journals Animal models of early life stress: Implications for understanding resilience

2010 ◽  
Vol 52 (5) ◽  
pp. 402-410 ◽  
Author(s):  
David M. Lyons ◽  
Karen J. Parker ◽  
Alan F. Schatzberg
Keyword(s):  
Animal Models ◽  
Life Stress ◽  
Early Life ◽  
Early Life Stress
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