scholarly journals Effect of cell phone radiofrequency radiation on body temperature in rodents: Pilot studies of the National Toxicology Program's reverberation chamber exposure system

2018 ◽  
Vol 39 (3) ◽  
pp. 190-199 ◽  
Author(s):  
Michael E. Wyde ◽  
Thomas L. Horn ◽  
Myles H. Capstick ◽  
John M. Ladbury ◽  
Galen Koepke ◽  
...  
Keyword(s):  
Body Temperature ◽  
Cell Phone ◽  
Pilot Studies ◽  
Reverberation Chamber ◽  
Exposure System ◽  
Radiofrequency Radiation ◽  
Chamber Exposure

scholarly journals Report of Partial Findings from the National Toxicology Program Carcinogenesis Studies of Cell Phone Radiofrequency Radiation in Hsd: Sprague Dawley® Sd Rats (Whole Body Exposure)

2016 ◽  
Author(s):  
Michael Wyde ◽  
Mark Cesta ◽  
Chad Blystone ◽  
Susan Elmore ◽  
Paul Foster ◽  
...  
Keyword(s):  
Mobile Communications ◽  
Cell Phone ◽  
Malignant Gliomas ◽  
Male Rats ◽  
Sprague Dawley ◽  
Exposure System ◽  
Radiofrequency Radiation ◽  
National Toxicology Program ◽  
The Brain ◽  
The U.S

AbstractThe U.S. National Toxicology Program (NTP) has carried out extensive rodent toxicology and carcinogenesis studies of radiofrequency radiation (RFR) at frequencies and modulations used in the U.S. telecommunications industry. This report presents partial findings from these studies. The occurrences of two tumor types in male Harlan Sprague Dawley rats exposed to RFR, malignant gliomas in the brain and schwannomas of the heart, were considered of particular interest and are the subject of this report. The findings in this report were reviewed by expert peer reviewers selected by the NTP and National Institutes of Health (NIH). These reviews and responses to comments are included as appendices to this report, and revisions to the current document have incorporated and addressed these comments. When the studies are completed, they will undergo additional peer review before publication in full as part of the NTP's Toxicology and Carcinogenesis Technical Reports Series. No portion of this work has been submitted for publication in a scientific journal. Supplemental information in the form of four additional manuscripts has or will soon be submitted for publication. These manuscripts describe in detail the designs and performance of the RFR exposure system, the dosimetry of RFR exposures in rats and mice, the results to a series of pilot studies establishing the ability of the animals to thermoregulate during RFR exposures, and studies of DNA damage. (1) Capstick M, Kuster N, Kuhn S, Berdinas-Torres V, Wilson P, Ladbury J, Koepke G, McCormick D, Gauger J, and Melnick R. A radio frequency radiation reverberation chamber exposure system for rodents; (2) Yijian G, Capstick M, McCormick D, Gauger J, Horn T, Wilson P, Melnick RL, and Kuster N. Life time dosimetric assessment for mice and rats exposed to cell phone radiation; (3) Wyde ME, Horn TL, Capstick M, Ladbury J, Koepke G, Wilson P, Stout MD, Kuster N, Melnick R, Bucher JR, and McCormick D. Pilot studies of the National Toxicology Program’s cell phone radiofrequency radiation reverberation chamber exposure system; (4) Smith-Roe SL, Wyde ME, Stout MD, Winters J, Hobbs CA, Shepard KG, Green A, Kissling GE, Tice RR, Bucher JR, and Witt KL. Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure.SUMMARYThe purpose of this communication is to report partial findings from a series of radiofrequency radiation (RFR) cancer studies in rats performed under the auspices of the U.S. National Toxicology Program (NTP).1 This report contains peer-reviewed, neoplastic and hyperplastic findings only in the brain and heart of Hsd:Sprague Dawley® SD® (HSD) rats exposed to RFR starting in utero and continuing throughout their lifetimes. These studies found low incidences of malignant gliomas in the brain and schwannomas in the heart of male rats exposed to RFR of the two types [Code Division Multiple Access (CDMA) and Global System for Mobile Communications (GSM)] currently used in U.S. wireless networks. Potentially preneoplastic lesions were also observed in the brain and heart of male rats exposed to RFR.The review of partial study data in this report has been prompted by several factors. Given the widespread global usage of mobile communications among users of all ages, even a very small increase in the incidence of disease resulting from exposure to RFR could have broad implications for public health. There is a high level of public and media interest regarding the safety of cell phone RFR and the specific results of these NTP studies. Lastly, the tumors in the brain and heart observed at low incidence in male rats exposed to GSM-and CDMA-modulated cell phone RFR in this study are of a type similar to tumors observed in some epidemiology studies of cell phone use. These findings appear to support the International Agency for Research on Cancer (IARC) conclusions regarding the possible carcinogenic potential of RFR.2It is important to note that this document reviews only the findings from the brain and heart and is not a complete report of all findings from the NTP’s studies. Additional data from these studies in Hsd:Sprague Dawley® SD® (Harlan) rats and similar studies conducted in B6C3F1/N mice are currently under evaluation and will be reported together with the current findings in two forthcoming NTP Technical Reports.

Development and Validation of Reverberation-Chamber Type Whole-Body Exposure System for Mobile-Phone Frequency

2008 ◽  
Vol 27 (1) ◽  
pp. 73-82 ◽  
Author(s):  
K. B. Jung ◽  
T. H. Kim ◽  
J. L. Kim ◽  
H. J. Doh ◽  
Y. C. Chung ◽  
...  
Keyword(s):  
Mobile Phone ◽  
Whole Body ◽  
Reverberation Chamber ◽  
Exposure System ◽  
Development And Validation

scholarly journals ICAT: Development of an Internet-Based Data Collection Method for Ecological Momentary Assessment Using Personal Cell Phones

2013 ◽  
Vol 29 (2) ◽  
pp. 140-148 ◽  
Author(s):  
Emmanuel Kuntsche ◽  
Florian Labhart
Keyword(s):  
Cell Phone ◽  
Large Scale ◽  
Cox Regression ◽  
Retention Rate ◽  
Cell Phones ◽  
Text Messages ◽  
Ease Of Use ◽  
Retention Rates ◽  
Baseline Assessment ◽  
Pilot Studies

Rapid advances in mobile data-transfer technologies offer new possibilities in the use of cell phones to conduct assessments of a person’s natural environment in real time. This paper describes features of a new Internet-based, cell phone-optimized assessment technique (ICAT), which consists of a retrospective baseline assessment combined with text messages sent to the participants’ personal cell phones providing a hyperlink to an Internet-stored cell phone-optimized questionnaire. Two participation conditions were used to test variations in response burden. Retention rates, completion rates, and response times in different subgroups were tested by means of χ² tests, Cox regression, and logistic regression. Among the 237 initial participants, we observed a retention rate of 90.3% from the baseline assessment to the cell-phone part, and 80.4% repeated participation in the 30 daily assessments. Each day, 40–70% of the questionnaires were returned, a fourth in less than 3 minutes. Qualitative interviews underscored the ease of use of ICAT. This technique appears to be an innovative, convenient, and cost-effective way of collecting data on situational characteristics while minimizing recall bias. Because of its flexibility, ICAT can be applied in various disciplines, whether as part of small pilot studies or large-scale, crosscultural, and multisite research projects.

scholarly journals Assessment of DNA Damage in Chick Embryo Brains Exposed to 2G and 3G Cell Phone Radiation using Alkaline Comet Assay Technique

2021 ◽  
Author(s):  
Mary Hydrina D'Silva ◽  
Rijied Thompson Swer ◽  
Jayaraman Anbalagan ◽  
Rajesh Bhargavan
Keyword(s):  
Dna Damage ◽  
Chick Embryo ◽  
Comet Assay ◽  
Cell Phone ◽  
Developing Brain ◽  
Chick Embryos ◽  
Alkaline Comet Assay ◽  
Radiofrequency Radiation ◽  
Experimental Group ◽  
Cell Phone Radiation

Introduction: The cellular phones/mobile phones have emerged as the fastest growing man-made phenomenon ever discovered in the history. Controversies still exist among the scientific community regarding the ill-effects of Radiofrequency Radiation (RFR) exposure from cell phones on biological tissues. The present study will provide an insight into the basic mechanisms by which RF fields interact with developing brain in an embryo. Aim: To assess the possible Deoxyribonucleic Acid (DNA) damage in developing brain of chick embryo following chronic exposure to Ultra-High Frequency/Radiofrequency Radiation (UHF/RFR) emitted from 2G and 3G cell phone. Materials and Methods: Fertilised hen eggs were divided into three groups. Experimental Group A (exposed to 2G radiation, 24 eggs), Experimental Group B (exposed to 3G radiation, 24 eggs) and Group C sham exposed control group (24 eggs). After the completion of scheduled duration of exposure (72 minutes per day), the chick embryos were sacrificed from 9th-12th day and the brains were dissected out. The chick embryo brains were then subjected to alkaline comet assay technique to assess the DNA damage. The results were statistically compared using one-way Analysis of Variance (ANOVA). Results: In the present study, the exposure of chick embryo brains to 2G and 3G cell phone radiation caused increased mean comet length (p<0.001), mean tail length (p<0.001), mean percentage of DNA in the tail (p<0.001) and mean tail moment (p<0.01) suggestive of increased DNA damage. Conclusion: The present study concludes that the RFR exposure caused significant increase in DNA damage in developing brain of chick embryos with changes more pronounced in 3G exposure group.

Body temperature in the mouse, hamster, and rat exposed to radiofrequency radiation: An interspecies comparison

1986 ◽  
Vol 11 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Christopher J. Gordon ◽  
Merrit D. Long ◽  
Kimi S. Fehlner ◽  
Andrew G. Stead
Keyword(s):  
Body Temperature ◽  
Interspecies Comparison ◽  
Radiofrequency Radiation

scholarly journals A vapor exposure method for delivering heroin alters nociception, body temperature and spontaneous activity in female and male rats

2020 ◽  
Author(s):  
Arnold Gutierrez ◽  
Kevin M. Creehan ◽  
Michael A. Taffe
Keyword(s):  
Body Temperature ◽  
Spontaneous Activity ◽  
Female Rats ◽  
Male Rats ◽  
Sprague Dawley ◽  
Exposure System ◽  
Male And Female ◽  
Male And Female Rats ◽  
Sprague Dawley Rats

AbstractBackgroundThe ongoing crisis related to non-medical use of opioids makes it of continued importance to understand the risk factors for opioid addiction, the behavioral and neurobiological consequences of opioid exposure and to seek potential avenues for therapy. Pre-clinical rodent models have been critical to advancing understanding of opioid consequences for decades, but have been mostly limited to drug delivery by injection or by oral dosing. Inhalation, a significant route for many human users, has not been as well-established.MethodWe adapted an e-cigarette based exposure system, previously shown efficacious for delivery of other drugs to rats, to deliver heroin vapor. Effects in vivo were assessed in male and female Sprague-Dawley rats using a warm-water assay for anti-nociception and an implanted radiotelemetry system for evaluating changes in body temperature and spontaneous activity rate.ResultsInhalation of vapor created by heroin 100 mg/mL in the propylene glycol (PG) vehicle significantly slowed tail-withdrawal from a 52°C water bath, bi-phasically altered activity, and increased temperature in male and female rats. Inhalation of heroin 50 mg/mL for 15 minutes produced significant effects, as the lower bound on efficacy, whereas inhalation of heroin 100 mg/mL for 30 minutes produced robust effects across all endpoints and groups.ConclusionsThis work shows that e-cigarette devices deliver psychoactive doses of heroin to rats, using concentrations of ∼50-100 mg/mL and inhalation durations of 15-30 minutes. This technique may be useful to assess the health consequences of inhaled heroin and other opioid drugs.

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