Pulsed electromagnetic field improves subchondral bone microstructure in knee osteoarthritis rats through a Wnt/β-catenin signaling-associated mechanism

2017 ◽  
Vol 39 (2) ◽  
pp. 89-97 ◽  
Author(s):  
Xiaotian Yang ◽  
Hongchen He ◽  
Qiang Gao ◽  
Chengqi He
Keyword(s):  
Electromagnetic Field ◽  
Knee Osteoarthritis ◽  
Subchondral Bone ◽  
Bone Microstructure ◽  
Pulsed Electromagnetic Field ◽  
Pulsed Electromagnetic

scholarly journals Pulsed Electromagnetic Field Affects the Development of Postmenopausal Osteoporotic Women with Vertebral Fractures

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Wei Liu ◽  
Xiao Jin ◽  
Zhiqiang Guan ◽  
Qiyun Zhou
Keyword(s):  
Electromagnetic Field ◽  
Treatment Group ◽  
Bone Loss ◽  
Vertebral Fractures ◽  
Bone Microstructure ◽  
Control Group ◽  
Pulsed Electromagnetic Field ◽  
Related Quality ◽  
Health Related ◽  
Pulsed Electromagnetic

Background. Postoperative pain, dysfunction, and significant bone loss may occur after vertebral fractures, which will lead to the occurrence of refractures and shorten the survival time, so postoperative rehabilitation is very important. Pulsed electromagnetic field therapy is noninvasive, pain-relieving, and beneficial to reduce bone loss and is an important treatment for patients to recover after surgery. Therefore, this study analyzed the effect of postmenopausal women’s vertebral fracture rehabilitation after pulsed electromagnetic field treatment. Method. This study uses a randomized controlled study, respectively, in the pulsed electromagnetic field treatment group (40 cases) and the control group (42 cases), respectively. We studied the results of health-related quality of life scores (HRQOL), back pain, body function, hip bone density, bone microstructure of tibia, and radius after 1 month and 3 months after surgery. Results. Compared with the control group, the pulsed electromagnetic field treatment group (PEMF) can improve significantly the psychological score, 6-minute walk test, and Chair Sit-and-Reach one month after the operation. And at 3 months after surgery, the pulsed electromagnetic field treatment group can improve significantly in health-related quality of life scores (HRQOL), back pain, and body function. Regarding the effect of changes in bone mass, compared with the control group, pulsed electromagnetic field treatment had no significant effect on changes in hip bone density. As a result of changes in bone microstructure, pulsed electromagnetic field treatment can significantly improve the bone microstructure of the radius and tibia three months after vertebral fractures. Conclusion. Pulsed electromagnetic field therapy has positive significance for improving pain, body functional changes, and bone loss after vertebral fracture surgery.

scholarly journals Effects of pulsed electromagnetic field on knee osteoarthritis: a systematic review

Rheumatology ◽  
2012 ◽  
Vol 52 (5) ◽  
pp. 815-824 ◽  
Author(s):  
Seo Ryang We ◽  
Yun Hyung Koog ◽  
Kwang-Il Jeong ◽  
Hyungsun Wi
Keyword(s):  
Systematic Review ◽  
Electromagnetic Field ◽  
Knee Osteoarthritis ◽  
Pulsed Electromagnetic Field ◽  
Pulsed Electromagnetic

scholarly journals AB1261 DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF PULSED ELECTROMAGNETIC FIELD THERAPY IN KNEE OSTEOARTHRITIS (PRELIMINARY RESULTS)

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1922.2-1922
Author(s):  
D. Karateev ◽  
A. Makevnina ◽  
A. Tangieva ◽  
E. Luchikhina ◽  
H. Hamhoeva
Keyword(s):  
Electromagnetic Field ◽  
Knee Osteoarthritis ◽  
Controlled Trial ◽  
Low Frequency ◽  
Clinical Parameters ◽  
Pulsed Electromagnetic Field ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Knee Oa ◽  
Pulsed Electromagnetic

Background:Pulsed electromagnetic field (PEMF) therapy is widely used in different areas of medicine. There are a lot of portable PEMF therapeutic devices on the market around the world. Nevertheless, the role of PEMF in treatment of rheumatic conditions is not clear. Current evidence is of low and very low quality.Objectives:To study efficacy and safety of PEMF therapy in primary and secondary osteoarthritis (OA) of the knee in controlled clinical trial.Methods:This abstract presents the preliminary results of an ongoing double-blind placebo-controlled trial of PEMF portable therapeutic device “ALMAG+” (Certificate EN ISO 13485:2012+AC:2012 reg.-No 44221 117836, Yelatma Instrument-Making Enterprise, Russian Federation, Reg. Num.: 3007075140). The device is intended for physiotherapeutic treatment and rehabilitation with a low-frequency low-intensity PEMF in medical institutions, as well as at home after the recommendation of a doctor. Patients with primary and secondary (as a part of inflammatory rheumatic disease) OA of knee with Kellgren-Lawrence Grade I-III included in the study (in patients with inflammatory conditions disease activity should be minimal on stable drug therapy). Three courses of PEMF of 20 procedures for 1 year planned in active treatment group and placebo (inactive device) group of 35 patients each. Efficacy is evaluated by pain VAS, WOMAC, Lequesne index, and quality of life studied using SF-36, EuroQoL 5D tools. Instrumental control with knee ultrasound and MRI investigations will be performed. The study protocol was approved by local Ethical Committee.Results:To date 23 patients (7 males, 16 females, age 54,6±11,2 years, primary knee OA – 16 pts, RA- 6 pts, AS – 1 pt) completed 1stcourse of PEMF. Table presents differences (Δ) in the main clinical parameters in active treatment and placebo device groups. No significant difference in ESR or CRP levels was found. No treatment-related adverse events has been reported.Table.Differences (Δ) in the main clinical parameters after a 1stcourse of PEMF.ParameterActive device (n=11)Placebo device (n=12)pΔ VAS pain in movement15 [0; 38,5]5 [1,25; 10,5]0,053Δ VAS pain in rest10 [0; 34]1 [0; 2,75]0,043Δ WOMAC3 [2; 10]2 [0; 4,5]0,174Δ Lequesne index3 [0; 4]1 [0,25; 2,5]0,258Conclusion:In this preliminary analysis pulsed electromagnetic field (PEMF) therapy showed significant impact on pain in rest in knee OA after one course of procedures.References:Negm A, Lorbergs A, Macintyre NJ. Efficacy of low frequency pulsed subsensory threshold electrical stimulation vs placebo on pain and physical function in people with knee osteoarthritis: systematic review with meta-analysis. Osteoarthritis Cartilage. 2013 Sep;21(9):1281-9. doi: 10.1016/j.joca.2013.06.015Disclosure of Interests:Dmitry Karateev Consultant of: Abbvie, Pfizer, Biocad, Sanofi, Novartis, Lilly, Speakers bureau: Abbvie, Roche, Pfizer, Biocad, MSD, Sanofi, Johnson & Johnson, Glaxo, UCB, Celgene, Novartis, Lilly, Bayer, Alexandra Makevnina Speakers bureau: Sanofi, Aminat Tangieva: None declared, Elena Luchikhina Consultant of: Abbvie, Biocad, Sanofi, Celgene, Speakers bureau: Abbvie, Roche, Pfizer, Biocad, MSD, Sanofi, Johnson & Johnson, Glaxo, UCB, Celgene, Novartis, Hava Hamhoeva: None declared

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