Exposure of murine cells to pulsed electromagnetic fields rapidly activates the mTOR signaling pathway

2006 ◽  
Vol 27 (7) ◽  
pp. 535-544 ◽  
Author(s):  
Thomas E. Patterson ◽  
Yoshitada Sakai ◽  
Mark D. Grabiner ◽  
Michael Ibiwoye ◽  
Ronald J. Midura ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Electromagnetic Fields ◽  
Mtor Signaling ◽  
Pulsed Electromagnetic Fields ◽  
Mtor Signaling Pathway ◽  
Pulsed Electromagnetic

Pulsed electromagnetic fields promote bone formation by activating the sAC–cAMP–PKA–CREB signaling pathway

2018 ◽  
Vol 234 (3) ◽  
pp. 2807-2821 ◽  
Author(s):  
Yuan‐Yuan Wang ◽  
Xiu‐Ying Pu ◽  
Wen‐Gui Shi ◽  
Qing‐Qing Fang ◽  
Xin‐Ru Chen ◽  
...  
Keyword(s):  
Bone Formation ◽  
Signaling Pathway ◽  
Electromagnetic Fields ◽  
Pulsed Electromagnetic Fields ◽  
Pulsed Electromagnetic

Effect of pulsed electromagnetic fields on maturation of regenerate bone in a rabbit limb lengthening model

2005 ◽  
Vol 24 (1) ◽  
pp. 2-10 ◽  
Author(s):  
Kenneth F. Taylor ◽  
Nozumu Inoue ◽  
Bahman Rafiee ◽  
John E. Tis ◽  
Kathleen A. McHale ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Limb Lengthening ◽  
Pulsed Electromagnetic Fields ◽  
Pulsed Electromagnetic

Effects of Pulsed Electromagnetic Fields on Rat Eye

1999 ◽  
Vol 18 (2) ◽  
pp. 157-164
Author(s):  
Gianluca Giavaresi ◽  
Francesco Broccoli ◽  
Milena Fini ◽  
Paola Torricelli ◽  
Paola Versura ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Pulsed Electromagnetic Fields ◽  
Pulsed Electromagnetic

UPF1 Impacts on mTOR Signaling Pathway and Autophagy in Endometrioid Endometrial Carcinoma

2020 ◽  
Author(s):  
Minfen Zhang ◽  
Hui Chen ◽  
Ping Qin ◽  
Tonghui Cai ◽  
Lingjun Li ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway

Targeting mammalian target of rapamycin: prospects for the treatment of inflammatory bowel diseases

2020 ◽  
Vol 27 ◽  
Author(s):  
Naser-Aldin Lashgari ◽  
Nazanin Momeni Roudsari ◽  
Saeideh Momtaz ◽  
Negar Ghanaatian ◽  
Parichehr Kohansal ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Mammalian Target Of Rapamycin ◽  
Mtor Pathway ◽  
Mtor Signaling ◽  
Target Of Rapamycin ◽  
In Vivo Studies ◽  
Cochrane Library ◽  
Mtor Signaling Pathway ◽  
Inflammatory Bowel

: Inflammatory bowel disease (IBD) is a general term for a group of chronic and progressive disorders. Several cellular and biomolecular pathways are implicated in the pathogenesis of IBD, yet the etiology is unclear. Activation of the mammalian target of rapamycin (mTOR) pathway in the intestinal epithelial cells was also shown to induce inflammation. This review focuses on the inhibition of the mTOR signaling pathway and its potential application in treating IBD. We also provide an overview on plant-derived compounds that are beneficial for the IBD management through modulation of the mTOR pathway. Data were extracted from clinical, in vitro and in vivo studies published in English between 1995 and May 2019, which were collected from PubMed, Google Scholar, Scopus and Cochrane library databases. Results of various studies implied that inhibition of the mTOR signaling pathway downregulates the inflammatory processes and cytokines involved in IBD. In this context, a number of natural products might reverse the pathological features of the disease. Furthermore, mTOR provides a novel drug target for IBD. Comprehensive clinical studies are required to confirm the efficacy of mTOR inhibitors in treating IBD.

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