The Inhibin B Response to a Motilin Receptor Agonist in Male Rats

2013 ◽  
Vol 98 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Mary K. Ziejewski ◽  
Justin D. Vidal ◽  
Dinesh Stanislaus ◽  
April Apostoli ◽  
Probash Chowdhury ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Inhibin B ◽  
Male Rats ◽  
Motilin Receptor

scholarly journals RQ-00201894: A motilin receptor agonist causing long-lasting facilitation of human gastric cholinergically-mediated contractions

2016 ◽  
Vol 130 (2) ◽  
pp. 60-65 ◽  
Author(s):  
John Broad ◽  
Nobuyuki Takahashi ◽  
Masaomi Tajimi ◽  
Masaki Sudo ◽  
Adam Góralczyk ◽  
...  
Keyword(s):  
Receptor Agonist ◽  
Motilin Receptor

scholarly journals Hepatoprotective effect of opioid peptides in stress

2019 ◽  
Vol 5 (1) ◽  
pp. 77-96
Author(s):  
Alexey V. Solin ◽  
Yury D. Lyashev ◽  
Nikolay V. Tsygan
Keyword(s):  
Liver Regeneration ◽  
Receptor Agonist ◽  
Immobilization Stress ◽  
Hepatoprotective Effect ◽  
Male Rats ◽  
Endogenous Opioid System ◽  
Dynorphin A ◽  
Endogenous Opioid ◽  
Limited Mobility ◽  
Swimming Stress

Introduction: Influence of the endogenous opioid system on the liver has not been studied enough. To understand the damaging effects of stress on the liver and the hepatoprotective effects of opioids, a study was performed on stress-resistant and stress-susceptible animals. Materials and methods: The investigation was performed on 725 Wistar male-rats. Various types of stress were modeled: acute immobilization stress of various duration (3, 6 and 12 hours), chronic stress of limited mobility, swimming stress and traumatic stress (resection of 70% of the liver). Agonists of various types of opioid receptors in equimolar doses were injected to stressed animals at equimolar doses: DAGO – a mu-receptor agonist – at a dose of 6.3 mcg/kg, DSLET – a delta-receptor agonist – at a dose of 10 mcg/kg, and kappa receptor agonist dynorphin A (1-13) – at a dose of 20.1 mcg/kg. Results and discussion: The stress-limiting action of the studied opioids is characterized by the reduced hepatocyte dystrophy, microcirculation correction, a decreased concentration of lipid peroxidation metabolites, a suppressed cytolytic syndrome, a stimulated synthetic ability of the liver, and is more pronounced in stress- susceptible animals. The greatest stress-protective effect is shown after administering dynorphin A (1-13) in immobilization stress, and DAGO – in swimming stress. Dynorphin A (1-13) and DAGO manifested the most pronounced effect on the liver regeneration after resection. A preliminary stress simulation accelerates liver regeneration at the initial stage after resection. Conclusion: The hepatoprotective effect of opioids in stress depends on the typological peculiarities of animals. The results obtained offer a challenge of synthesizing new hepatoprotectors.

W1390 Characterization of a Novel, Potent, and Selective Small Molecule Motilin Receptor Agonist, RQ-00201894

2010 ◽  
Vol 138 (5) ◽  
pp. S-713 ◽  
Author(s):  
Nobuyuki Takahashi ◽  
Naomi Koba ◽  
Toshinori Yamamoto ◽  
Masaki Sudo
Keyword(s):  
Small Molecule ◽  
Receptor Agonist ◽  
Motilin Receptor

The Inhibin B Response in Male Rats Treated with Two Drug Candidates

2013 ◽  
Vol 98 (1) ◽  
pp. 54-62 ◽  
Author(s):  
Robert E. Chapin ◽  
James D. Alvey ◽  
Richard A. Goldstein ◽  
Melba G. Dokmanovich ◽  
William J. Reagan ◽  
...  
Keyword(s):  
Inhibin B ◽  
Male Rats ◽  
Drug Candidates

235 PF-04548043, a Novel Motilin Receptor Agonist, Increases Gastric Emptying in Healthy Volunteers and Does Not Undergo Tachyphylaxis

2009 ◽  
Vol 136 (5) ◽  
pp. A-45 ◽  
Author(s):  
Jeremy D. Gale ◽  
Peter J. Colman ◽  
Constantino Kantaridis ◽  
Catherine Claes ◽  
Radu Tutuian
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Receptor Agonist ◽  
Motilin Receptor

The Inhibin B Response in Male Rats Treated with a GnRH Agonist and an Endothelin Receptor Antagonist

2013 ◽  
Vol 98 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Michelle Coulson ◽  
Terri Mitchard ◽  
Sue Bickerton ◽  
Jayne Harris ◽  
Catherine Betts ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Gnrh Agonist ◽  
Inhibin B ◽  
Endothelin Receptor Antagonist ◽  
Male Rats ◽  
Endothelin Receptor
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