The effect of intrahippocampal injection of testosterone enanthate (an androgen receptor agonist) and anisomycin (protein synthesis inhibitor) on spatial learning and memory in adult, male rats

2005 ◽  
Vol 156 (2) ◽  
pp. 263-268 ◽  
Author(s):  
Nasser Naghdi ◽  
Nahid Majlessi ◽  
Tahereh Bozorgmehr
Keyword(s):  
Protein Synthesis ◽  
Androgen Receptor ◽  
Spatial Learning ◽  
Receptor Agonist ◽  
Male Rats ◽  
Spatial Learning And Memory ◽  
Protein Synthesis Inhibitor ◽  
Testosterone Enanthate ◽  
Synthesis Inhibitor ◽  
Intrahippocampal Injection

scholarly journals The change in the content of certain hormones in the blood of rats under the central action of proteolysis inhibitors and protein synthesis

1997 ◽  
Vol 43 (4) ◽  
pp. 46-47
Author(s):  
D. B. Sandakov ◽  
I. N. Semenenya ◽  
A. V. Gurin
Keyword(s):  
Protein Synthesis ◽  
Male Rats ◽  
Protein Synthesis Inhibitor ◽  
Intracerebroventricular Injection ◽  
Central Action ◽  
Central Administration ◽  
Synthesis Inhibitor ◽  
Serum Progesterone ◽  
Thyrotropic Hormone ◽  
Thyroid Hormone Levels

Changes in the blood serum progesterone, estradiol, thyrotropic and thyroid hormone levels after intracerebroventricular injection of protease inhibitor contrycal in a dose of 100 ng and protein synthesis inhibitor anisomycin in a dose of 50 pg were studied in male rats. Central administration of contrycal significantly decreased the levels of thyrotropic hormone (p<0.05) and estradiol (p<0.001) and increased the level of T4 (p<0.05). Central administration of anisomycin decreased the levels of thyrotropic hormone (p<0.001) and estradiol. The latency of alteration of thyrotropic hormone and T4 levels is within 1 to 3 h, that of estradiol less than 1 h.

scholarly journals Effect of emetine, a protein synthesis inhibitor, on larval tail resorption in the ascidian Halocynthia roretzi

2006 ◽  
Vol 23 (2) ◽  
pp. 43-46
Author(s):  
Kiyotaka Matsumura ◽  
Manami Nagano ◽  
Sachiko Tsukamoto ◽  
Haruko Kato ◽  
Nobuhiro Fusetani
Keyword(s):  
Protein Synthesis ◽  
Protein Synthesis Inhibitor ◽  
Synthesis Inhibitor ◽  
Halocynthia Roretzi

scholarly journals Effects of testosterone on spatial learning and memory in adult male rats

2011 ◽  
Vol 59 (4) ◽  
pp. 484-496 ◽  
Author(s):  
Mark D. Spritzer ◽  
Emily D. Daviau ◽  
Meagan K. Coneeny ◽  
Shannon M. Engelman ◽  
W. Tyler Prince ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Spatial Learning ◽  
Adult Male ◽  
Male Rats ◽  
Spatial Learning And Memory

scholarly journals Local protein synthesis of neuronal MT1-MMP for agrin-induced presynaptic development

Development ◽  
2021 ◽  
Vol 148 (10) ◽  
Author(s):  
Jun Yu ◽  
Marilyn Janice Oentaryo ◽  
Chi Wai Lee
Keyword(s):  
Protein Synthesis ◽  
Neuronal Development ◽  
Neuromuscular Junctions ◽  
Neuronal Cell ◽  
Time Lapse ◽  
Protein Synthesis Inhibitor ◽  
Synthesis Inhibitor ◽  
Local Protein Synthesis ◽  
Presynaptic Differentiation ◽  
Local Protein

ABSTRACT Upon the stimulation of extracellular cues, a significant number of proteins are synthesized distally along the axon. Although local protein synthesis is crucial for various stages throughout neuronal development, its involvement in presynaptic differentiation at developing neuromuscular junctions remains unknown. By using axon severing and microfluidic chamber assays, we first showed that treatment of a protein synthesis inhibitor, cycloheximide, inhibits agrin-induced presynaptic differentiation in cultured Xenopus spinal neurons. Newly synthesized proteins are prominently detected, as revealed by the staining of click-reactive cell-permeable puromycin analog O-propargyl-puromycin, at agrin bead-neurite contacts involving the mTOR/4E-BP1 pathway. Next, live-cell time-lapse imaging demonstrated the local capturing and immobilization of ribonucleoprotein granules upon agrin bead stimulation. Given that our recent study reported the roles of membrane-type 1 matrix metalloproteinase (MT1-MMP) in agrin-induced presynaptic differentiation, here we further showed that MT1-MMP mRNA is spatially enriched and locally translated at sites induced by agrin beads. Taken together, this study reveals an essential role for axonal MT1-MMP translation, on top of the well-recognized long-range transport of MT1-MMP proteins synthesized from neuronal cell bodies, in mediating agrin-induced presynaptic differentiation.

Sign in / Sign up

Export Citation Format

Share Document