Maternal genetic polymorphisms of phase II metabolic enzymes and the risk of fetal neural tube defects

2013 ◽  
Vol 100 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Linlin Wang ◽  
Lei Jin ◽  
Jufen Liu ◽  
Yali Zhang ◽  
Yue Yuan ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Phase Ii ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Metabolic Enzymes

scholarly journals Association of neural tube defects with maternal alterations and genetic polymorphisms in one-carbon metabolic pathway

2019 ◽  
Vol 45 (1) ◽  
Author(s):  
Chun-Quan Cai ◽  
Yu-Lian Fang ◽  
Jian-Bo Shu ◽  
Lin-Sheng Zhao ◽  
Rui-Ping Zhang ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Metabolic Pathway

scholarly journals Genetic Polymorphisms of Phase II Metabolic Enzymes and Lung Cancer Susceptibility in a Population of Central South China

2006 ◽  
Vol 22 (3) ◽  
pp. 141-152 ◽  
Author(s):  
Han-chun Chen ◽  
Yan-fei Cao ◽  
Wei-xin Hu ◽  
Xin-fa Liu ◽  
Qing-xia Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Ethnic Group ◽  
Genetic Polymorphisms ◽  
Phase Ii ◽  
South China ◽  
Metabolic Enzymes ◽  
Hunan Province ◽  
Slow Acetylator ◽  
Increased Risk ◽  
Central South

A case-control study was conducted for analyzing the genetic polymorphisms of phase II metabolic enzymes in 97 patients with lung cancer and 197 healthy subjects from Han ethnic group of Hunan Province located in Central South China. The results showed that the frequencies of glutathione S-transferase (GST) M1-null (GSTM1-) or GSTT1-null (GSTT1-) genotype alone, or combined form of both in lung cancer patients were significantly higher than those of the controls. Genotypes of combining GSTP1 mutant/GSTM1(-) or GSTP1 mutant/GSTT1(-) led to high risk of lung cancer. Individuals carrying any two or all three of GSTM1(-), GSTT1(-) and GSTP1 mutant genotypes have a distinctly increased risk of lung cancer when compared to those with GSTM1 present (GSTM1+: GSTM1+/+ or GSTM1+/−), GSTT1 present (GSTT1+: GSTT1+/+ or GSTT1+/−) and GSTP1 wild genotypes. Furthermore, individuals possessing combined genotypes of N-acetyltransferase 2 (NAT2) rapid acetylator, GSTP1 mutant and both GSTT1(-) and GSTM1(-) have a remarkably higher lung cancer risk than those carrying combined NAT2 slow acetylator genotype, GSTP1 wild genotype and both GSTT1(+) and GSTM1(+) genotypes. All these findings suggest that the genetic polymorphisms of phase II metabolic enzymes affect the susceptibility of lung cancer in the Han ethnic group of Central South China.

Lessons from dolutegravir and neural tube defects

2021 ◽  
Vol 8 (1) ◽  
pp. e3-e4
Author(s):  
Elaine Abrams ◽  
Landon Myer
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects

A Public Health Success Story: Folic Acid Fortification and Supplementation for Prevention of Neural Tube Defects

2004 ◽  
Author(s):  
Linda Longerich ◽  
Roy West ◽  
Ed Randell ◽  
Marian Crowley ◽  
Shiliang Liu ◽  
...  
Keyword(s):  
Public Health ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Success Story ◽  
Folic Acid Fortification
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