scholarly journals Genetic Polymorphisms of Phase II Metabolic Enzymes and Lung Cancer Susceptibility in a Population of Central South China

2006 ◽  
Vol 22 (3) ◽  
pp. 141-152 ◽  
Author(s):  
Han-chun Chen ◽  
Yan-fei Cao ◽  
Wei-xin Hu ◽  
Xin-fa Liu ◽  
Qing-xia Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Ethnic Group ◽  
Genetic Polymorphisms ◽  
Phase Ii ◽  
South China ◽  
Metabolic Enzymes ◽  
Hunan Province ◽  
Slow Acetylator ◽  
Increased Risk ◽  
Central South

A case-control study was conducted for analyzing the genetic polymorphisms of phase II metabolic enzymes in 97 patients with lung cancer and 197 healthy subjects from Han ethnic group of Hunan Province located in Central South China. The results showed that the frequencies of glutathione S-transferase (GST) M1-null (GSTM1-) or GSTT1-null (GSTT1-) genotype alone, or combined form of both in lung cancer patients were significantly higher than those of the controls. Genotypes of combining GSTP1 mutant/GSTM1(-) or GSTP1 mutant/GSTT1(-) led to high risk of lung cancer. Individuals carrying any two or all three of GSTM1(-), GSTT1(-) and GSTP1 mutant genotypes have a distinctly increased risk of lung cancer when compared to those with GSTM1 present (GSTM1+: GSTM1+/+ or GSTM1+/−), GSTT1 present (GSTT1+: GSTT1+/+ or GSTT1+/−) and GSTP1 wild genotypes. Furthermore, individuals possessing combined genotypes of N-acetyltransferase 2 (NAT2) rapid acetylator, GSTP1 mutant and both GSTT1(-) and GSTM1(-) have a remarkably higher lung cancer risk than those carrying combined NAT2 slow acetylator genotype, GSTP1 wild genotype and both GSTT1(+) and GSTM1(+) genotypes. All these findings suggest that the genetic polymorphisms of phase II metabolic enzymes affect the susceptibility of lung cancer in the Han ethnic group of Central South China.

Association of NAT-2 gene polymorphisms toward lung cancer susceptibility and prognosis in North Indian patients treated with platinum-based chemotherapy

2021 ◽  
Author(s):  
Harleen Kaur Walia ◽  
Navneet Singh ◽  
Siddharth Sharma
Keyword(s):  
Lung Cancer ◽  
Prognostic Factor ◽  
Cancer Susceptibility ◽  
Healthy Controls ◽  
Slow Acetylator ◽  
Mutant Genotype ◽  
Platinum Based Chemotherapy ◽  
Increased Risk ◽  
Significant Difference ◽  
Potential Prognostic Factor

Aim: The present study has been carried out to evaluate the association of the N-acetyl transferase 2 ( NAT2) variants in North Indian lung cancer patients and healthy controls. Furthermore, we have also determined the effect of the polymorphic variants of the NAT2 gene on the clinical outcomes and overall survival among lung cancer (LC) subjects treated with platinum-based doublet chemotherapy. Methods: This case-control study comprised a total of 550 cases and 550 healthy controls. The genotyping was carried out using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and the statistical analysis was carried out using MedCalc. Results: There was a lack of any significant association for both 590G>A and 803A>G polymorphisms toward risk for LC, but 857G>A polymorphism exhibited a risk toward LC (p = 0.005). Whereas, variant alleles for the 481C>T polymorphism had a decreased risk for LC (p = 0.0003). Further, 857G>A polymorphism conferred a positive association between genotype and ADCC (p = 0.001) and 481C>T polymorphism had a decreased risk for SQCC (OR = 0.39, p = 0.0006) and SCLC (p = 0.001) subjects. The smokers carrying mutant genotype for the 481C>T polymorphism had a decreased risk toward LC (p < 0.0001) even in light (p = 0.002) as well as heavy smokers (p = 0.001). In case of females, 2.59-fold and 3.66-fold increased risk of LC development was observed in subjects with intermediate and slow acetylator for the 857G>A polymorphism. Whereas, in case of males this polymorphism depicts a reduced risk for LC. On the other hand, 803A>G depicted a 2.82-fold risk of LC in case of female subjects who were slow acetylators. Our study exhibits a significant difference in the overall haplotype distribution between cases and controls. In our study overall, (857G>A, 481C>T, 803A>G) was found to be best model, but was not significant using MDR. Considering the CART results 481C>T polymorphism came out to be the most significant factor in determining the LC risk. For the 803A>G polymorphism, a threefold odds of lymph node invasion were observed for mutant genotype, the recessive model exhibited an odd of 2.8. 590G>A appears to be a potential prognostic factor for OS of SCLC patients after irinotecan therapy as the survival time for such patients was better. Conclusion: These results suggest that NAT2 variant genotype for 590G>A and 803A>G was not found to modulate risk toward LC, but 857G>A polymorphism exhibited a risk toward LC and 481C>T polymorphism had a decreased risk for LC. NAT2 590G>A appears to be a potential prognostic factor for OS of SCLC patients after irinotecan therapy and 481C>T came out to be significant factor using CART.

scholarly journals NAT2 slow acetylator genotype is associated with increased risk of lung cancer among non-smoking Chinese women in Singapore

1999 ◽  
Vol 20 (9) ◽  
pp. 1877-1881 ◽  
Author(s):  
Adeline Seow ◽  
Bin Zhao ◽  
Wee-Teng Poh ◽  
Ming Teh ◽  
Philip Eng ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Chinese Women ◽  
Slow Acetylator ◽  
Increased Risk ◽  
Acetylator Genotype

Genetic polymorphism of 17 STR loci in Chinese population from Hunan province in Central south China

2012 ◽  
Vol 6 (5) ◽  
pp. e151-e153 ◽  
Author(s):  
Yun-feng Chang ◽  
Ji-fang Wen ◽  
Li Yang ◽  
Ji-feng Cai ◽  
Sanaa Mohamed Aly ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
South China ◽  
Chinese Population ◽  
Hunan Province ◽  
Str Loci ◽  
Central South

Association between EGF +61 genetic polymorphisms and non-small cell lung cancer increased risk in a Portuguese population: a case–control study

Tumor Biology ◽  
2012 ◽  
Vol 33 (5) ◽  
pp. 1341-1348 ◽  
Author(s):  
Ramon Andrade de Mello ◽  
Mónica Ferreira ◽  
Sandra Costa ◽  
Bruno Marques Costa ◽  
Filipa Soares Pires ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Genetic Polymorphisms ◽  
Case Control Study ◽  
Case Control ◽  
Small Cell ◽  
Small Cell Lung ◽  
Portuguese Population ◽  
Increased Risk ◽  
Control Study

scholarly journals Lycoris wulingensis, a dwarf new species of Amaryllidaceae from Hunan, China

PhytoKeys ◽  
2021 ◽  
Vol 177 ◽  
pp. 1-9
Author(s):  
Si-Yu Zhang ◽  
Ying Huang ◽  
Pei Zhang ◽  
Ke-Run Zhu ◽  
Yong-Bing Chen ◽  
...  
Keyword(s):  
New Species ◽  
South China ◽  
Hunan Province ◽  
East China ◽  
Diploid Plant ◽  
Hybrid Species ◽  
Original Species ◽  
Central South ◽  
A New Species

Lycoris wulingensis S.Y. Zhang, a new species from Hunan Province (central South China), is described and illustrated. This new species is a fertile diploid plant and its karyotype is 2n = 22. It is most similar to L. × haywardii in morphology, but the latter is a hybrid species and distributed in East China and the plant is much larger. Amongst the original species, L. wulingensis is similar to L. radiata, but differs from it in its flowers being rose-red (vs. red) and stamens and tepals are nearly the same length (vs. stamens significantly longer than tepals).

Prevalence of HPV infection among 157,038 Chinese females in Hunan Province, central-south China: Research article

2019 ◽  
Author(s):  
Chen Wang ◽  
Songshu Xiao ◽  
Sili He ◽  
Qiong Pan ◽  
Jie Zeng ◽  
...  
Keyword(s):  
Infection Rate ◽  
South China ◽  
Hpv Infection ◽  
Hunan Province ◽  
Genotype Distribution ◽  
The Third ◽  
Research Article ◽  
Hpv Types ◽  
The Common ◽  
Central South

Abstract Background: In the present study, we aimed to investigate the human papillomavirus (HPV) infection rate in females of Hunan Province, China, as well as the common HPV genotype distribution. Moreover, we also explored the differences in HPV infections among females of different ages. Methods: Clinical data were collected from 157,038 females who had tested HPV infection in the Third Xiangya Hospital of Central South University from November, 2010 to May, 2017. Results: The overall HPV infection rate was 19.91%.The most commonly detected genotypes were HPV52 (4.62%), HPV16 (3.52%), HPV 58(3.12%), HPVCP8304 (2.91%), and HPV53 (2.06%). The highest infection rate was found in females under the age of 20 (30.33%), the second highest infection rate was found in females over the age of 60 (24.72%), and females aged 30-39 showed the lowest HPV infection rate (18.11%). In addition, 71.32% of the infections were single HPV infections. Among the multiple HPV infections, HPV16/HPV6 co-infection was the most commonly detected combination (0.52%). Conclusions: In this study, we examined the epidemiology of HPV and the prevalence of the common HPV infection in Hunan Province, central-south China. We have revealed the prevalence and distribution of the different HPV types. Our study showed that females under the age of 20 and over the age of 60 were at higher risk of HPV infection than females of other ages. Moreover, our region should make extra efforts to the prevention and treatment of HPV52, HPV16 and HPV58 infections.

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