scholarly journals Association between reported venlafaxine use in early pregnancy and birth defects, national birth defects prevention study, 1997-2007

2012 ◽  
Vol 97 (1) ◽  
pp. 28-35 ◽  
Author(s):  
Kara N. D. Polen ◽  
Sonja A. Rasmussen ◽  
Tiffany Riehle-Colarusso ◽  
Jennita Reefhuis ◽  
Keyword(s):  
Birth Defects ◽  
Early Pregnancy ◽  
Prevention Study ◽  
Pregnancy And Birth

Maternal occupation as a nail technician or hairdresser during pregnancy and birth defects, National Birth Defects Prevention Study, 1997–2011

2021 ◽  
pp. oemed-2021-107561
Author(s):  
Miriam R Siegel ◽  
Carissa M Rocheleau ◽  
Kendra Broadwater ◽  
Albeliz Santiago-Colón ◽  
Candice Y Johnson ◽  
...  
Keyword(s):  
Birth Defects ◽  
Cleft Lip ◽  
Population Based ◽  
Small Samples ◽  
Prevention Study ◽  
Control Data ◽  
Reproductive Effects ◽  
Race Ethnicity ◽  
Maternal Occupation ◽  
Pregnancy And Birth

ObjectiveNail technicians and hairdressers may be exposed to chemicals with potential reproductive effects. While studies have examined birth defects in children of hairdressers, those in children of nail technicians have not been evaluated. We investigated associations between selected birth defects and maternal occupation as a nail technician or hairdresser versus a non-cosmetology occupation during pregnancy.MethodsWe analysed population-based case–control data from the multisite National Birth Defects Prevention Study, 1997–2011. Cases were fetuses or infants with major structural birth defects; controls were live-born infants without major birth defects. Expert raters classified self-reported maternal jobs as nail technician, combination nail technician-hairdresser, hairdresser, other cosmetology work or non-cosmetology work. We used logistic regression to calculate adjusted ORs and 95% CIs for associations between occupation during pregnancy and birth defects, controlling for age, smoking, education and race/ethnicity.ResultsSixty-one mothers worked as nail technicians, 196 as hairdressers, 39 as combination nail technician-hairdressers and 42 810 as non-cosmetologists. The strongest associations among nail technicians included seven congenital heart defect (CHD) groups (ORs ranging from 2.7 to 3.5) and neural tube defects (OR=2.6, CI=0.8 to 8.4). Birth defects most strongly associated with hairdressing included anotia/microtia (OR=2.1, CI=0.6 to 6.9) and cleft lip with cleft palate (OR=2.0, CI=1.1 to 3.7). All oral cleft groups were associated with combination nail technician-hairdresser work (ORs ranging from 4.2 to 5.3).ConclusionsSmall samples resulted in wide CIs. Still, results suggest associations between maternal nail technician work during pregnancy and CHDs and between hairdressing work and oral clefts.

scholarly journals Maternal report of fever from cold or flu during early pregnancy and the risk for noncardiac birth defects, National Birth Defects Prevention Study, 1997-2011

2017 ◽  
Vol 110 (4) ◽  
pp. 342-351 ◽  
Author(s):  
Dorothy Kim Waller ◽  
Syed Shahrukh Hashmi ◽  
Adrienne T. Hoyt ◽  
Hao T. Duong ◽  
Sarah C. Tinker ◽  
...  
Keyword(s):  
Birth Defects ◽  
Early Pregnancy ◽  
Prevention Study ◽  
Maternal Report

scholarly journals Assessment of Antihistamine Use in Early Pregnancy and Birth Defects

2013 ◽  
Vol 1 (6) ◽  
pp. 666-674.e1 ◽  
Author(s):  
Qian Li ◽  
Allen A. Mitchell ◽  
Martha M. Werler ◽  
Wai-Ping Yau ◽  
Sonia Hernández-Díaz
Keyword(s):  
Birth Defects ◽  
Early Pregnancy ◽  
Pregnancy And Birth

scholarly journals Maternal Occupational Oil Mist Exposure and Birth Defects, National Birth Defects Prevention Study, 1997–2011

2019 ◽  
Vol 16 (9) ◽  
pp. 1560
Author(s):  
Miriam Siegel ◽  
Carissa M. Rocheleau ◽  
Candice Y. Johnson ◽  
Martha A. Waters ◽  
Christina C. Lawson ◽  
...  
Keyword(s):  
Birth Defects ◽  
Early Pregnancy ◽  
Heart Defects ◽  
Cumulative Exposure ◽  
Prevention Study ◽  
Apparel Manufacturing ◽  
Reproductive Effects ◽  
Occupationally Exposed ◽  
Oil Mist ◽  
Using Data

Workers in various industries can be exposed to oil mists when oil-based fluids are aerosolized during work processes. Oil mists can be inhaled or deposited on the skin. Little research exists on the reproductive effects of oil mist exposure in pregnant workers. We aimed to investigate associations between occupational oil mist exposure in early pregnancy and a spectrum of birth defects using data from 22,011 case mothers and 8140 control mothers in the National Birth Defects Prevention Study. In total, 150 mothers were rated as exposed. Manufacturing jobs, particularly apparel manufacturing, comprised the largest groups of exposed mothers. Mothers of infants with septal heart defects (odds ratio (OR): 1.8, 95% confidence interval (CI): 1.0–3.3), and especially perimembranous ventricular septal defects (OR: 2.5, CI: 1.2–5.2), were more likely to be occupationally exposed to oil mists in early pregnancy than control mothers; and their rater-estimated cumulative exposure was more likely to be higher. This was the first U.S. study evaluating associations between oil mist exposure and a broad spectrum of birth defects. Our results are consistent with previous European studies, supporting a potential association between oil-based exposures and congenital heart defects. Further research is needed to evaluate the reproductive effects of occupational oil mist exposure.

scholarly journals Birth defects after use of antithyroid drugs in early pregnancy: a Swedish nationwide study

2017 ◽  
Vol 177 (4) ◽  
pp. 369-378 ◽  
Author(s):  
Stine Linding Andersen ◽  
Stefan Lönn ◽  
Peter Vestergaard ◽  
Ove Törring
Keyword(s):  
Birth Defects ◽  
Early Pregnancy ◽  
Cumulative Incidence ◽  
Heart Defects ◽  
Choanal Atresia ◽  
Antithyroid Drugs ◽  
Urinary System ◽  
Teratogenic Effects ◽  
Pregnancy And Birth ◽  
In Pregnancy

Objective Antithyroid drugs (ATDs) may have teratogenic effects, but more evidence is needed on the risk and types of birth defects after the use of methimazole (MMI) and propylthiouracil (PTU). This study aimed to evaluate the association between the use of ATDs in early pregnancy and birth defects. Design Swedish nationwide register-based cohort study. Methods The study included 684 340 children live-born in Sweden from 2006 to 2012. Exposure groups defined by maternal ATD use in early pregnancy were MMI (n = 162); PTU (n = 218); MMI and PTU (n = 66); ATD before or after, but not in pregnancy (n = 1551) and non-exposed (never ATD (n = 682 343)). Outcome was cumulative incidence of birth defects diagnosed before two years of age. Results The cumulative incidence of birth defects was not significantly different in children exposed to MMI (6.8%, P = 0.6) or PTU (6.4%, P = 0.4) vs non-exposed (8.0%). For subtypes of birth defects, MMI was associated with an increased incidence of septal heart defects (P = 0.02). PTU was associated with ear (P = 0.005) and obstructive urinary system malformations (P = 0.006). A case of choanal atresia was observed after exposure to both MMI and PTU. The incidence of birth defects in children born to mothers who received ATD before or after, but not in pregnancy, was 8.8% and not significantly different from non-exposed (P = 0.3), MMI exposed (P = 0.4) or PTU exposed (P = 0.2). Conclusions MMI and PTU were associated with subtypes of birth defects previously reported, but the frequency of ATD exposure in early pregnancy was low and severe malformations described in the MMI embryopathy were rarely observed.

scholarly journals ADHD Medication Use During Pregnancy and Risk for Selected Birth Defects: National Birth Defects Prevention Study, 1998-2011

2018 ◽  
Vol 24 (3) ◽  
pp. 479-489 ◽  
Author(s):  
Kayla N. Anderson ◽  
Annelise C. Dutton ◽  
Cheryl S. Broussard ◽  
Sherry L. Farr ◽  
Jennifer N. Lind ◽  
...  
Keyword(s):  
Birth Defects ◽  
Early Pregnancy ◽  
Medication Use ◽  
Population Based ◽  
Adhd Medication ◽  
Prevention Study ◽  
Crude Odds Ratio ◽  
Maternal Characteristics ◽  
Limb Deficiency ◽  
Control Study

Objective: The objective of this study was to examine the prevalence of, and maternal characteristics associated with, ADHD medication use before and during pregnancy, and associations between early pregnancy ADHD medication use and risk for 12 selected birth defects. Method: We used data from the National Birth Defects Prevention Study (1998-2011), a U.S. population–based case-control study examining risk factors for major structural birth defects. Results: There was an increase in ADHD medication use from 1998-1999 (0.2%) to 2010-2011 (0.5%; p < .001). Early pregnancy ADHD medication use was more commonly reported by mothers of infants/fetuses with gastroschisis (crude odds ratio [cOR]: 2.9, 95% confidence interval [CI] = [1.2, 6.9]), omphalocele (cOR: 4.0, 95% CI = [1.2, 13.6]), and transverse limb deficiency (cOR: 3.3, 95% CI = [1.1, 9.6]). Conclusion: ADHD medication use before and during pregnancy was rare, but the prevalence of use has increased over time. In this analysis, early pregnancy ADHD medication use was associated with three of 12 selected birth defects.

Use of antihistamine medications during early pregnancy and selected birth defects: The National Birth Defects Prevention Study, 1997–2011

2020 ◽  
Vol 112 (16) ◽  
pp. 1234-1252
Author(s):  
Craig Hansen ◽  
Tania A. Desrosiers ◽  
Kathy Wisniewski ◽  
Matthew J. Strickland ◽  
Martha M. Werler ◽  
...  
Keyword(s):  
Birth Defects ◽  
Early Pregnancy ◽  
Prevention Study

scholarly journals Atypical antipsychotic use during pregnancy and birth defect risk: National Birth Defects Prevention Study, 1997–2011

2020 ◽  
Vol 215 ◽  
pp. 81-88 ◽  
Author(s):  
Kayla N. Anderson ◽  
Elizabeth C. Ailes ◽  
Jennifer N. Lind ◽  
Cheryl S. Broussard ◽  
Rebecca H. Bitsko ◽  
...  
Keyword(s):  
Atypical Antipsychotic ◽  
Birth Defects ◽  
Birth Defect ◽  
Prevention Study ◽  
Pregnancy And Birth
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